PROCHÁZKOVÁ, Dagmar, Lucie KOLBOVÁ, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ and Zdeněk DOLEŽEL. Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients. In J Inherit Metab Dis 35, 2012,Suppl1, S 44. 2012. ISSN 0141-8955. |
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@proceedings{989618, author = {Procházková, Dagmar and Kolbová, Lucie and Jarkovský, Jiří and Vinohradská, Hana and Konečná, Petra and Doležel, Zdeněk}, booktitle = {J Inherit Metab Dis 35, 2012,Suppl1, S 44}, keywords = {PKU HPA pre-albumin trace elements}, language = {eng}, title = {Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients}, year = {2012} }
TY - CONF ID - 989618 AU - Procházková, Dagmar - Kolbová, Lucie - Jarkovský, Jiří - Vinohradská, Hana - Konečná, Petra - Doležel, Zdeněk PY - 2012 TI - Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients KW - PKU HPA pre-albumin trace elements N2 - Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy. ER -
PROCHÁZKOVÁ, Dagmar, Lucie KOLBOVÁ, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ and Zdeněk DOLEŽEL. Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients. In \textit{J Inherit Metab Dis 35, 2012,Suppl1, S 44}. 2012. ISSN~0141-8955.
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