BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Daniela KODYTKOVÁ, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Anna VAŠKŮ and Jaroslav ŠTĚRBA. BAFF Levels Are Elevated in Paediatric Patients With Acute Lymphoblastic Leukaemia Compared to Other B-Lineage Neoplasms. Journal of Hematology. Elmer Press, 2012, vol. 1, No 1, p. 20-22. ISSN 1927-1212. doi:10.4021/jh104e.
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Original name BAFF Levels Are Elevated in Paediatric Patients With Acute Lymphoblastic Leukaemia Compared to Other B-Lineage Neoplasms
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic, belonging to the institution), Daniela KODYTKOVÁ (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution).
Edition Journal of Hematology, Elmer Press, 2012, 1927-1212.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Canada
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/12:00060622
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.4021/jh104e
Keywords in English B-cell activating factor; Acute lymphoblastic leukaemia; B-cell lymphoma; Paediatric
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 20. 8. 2012 11:05.
Abstract
There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients (Bcp-ALL: 7764 plus-minus 6329 pg/ml, Bcell lymphoma: 2675 plus-minus 1544 pg/ml; P = 0.0268), the circulating levels of BAFF being substantially higher in B-ALL cases.
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JH_BAFF.pdf   File version Petr, M. 20. 8. 2012

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  • a concrete person Ing. Daniela Kodytková, Ph.D., učo 103451
  • a concrete person prof. MUDr. Anna Vašků, CSc., učo 122
  • a concrete person Mgr. Marie Tomandlová, Ph.D., učo 1693
  • a concrete person prof. MUDr. Jaroslav Štěrba, Ph.D., učo 348
  • a concrete person doc. RNDr. Josef Tomandl, Ph.D., učo 47
  • a concrete person prof. MUDr. Julie Dobrovolná, Ph.D., učo 4805
  • a concrete person Bc. Petr Bienert, učo 50773
  • a concrete person Mgr. Michal Petr, učo 65024
  • a concrete person Mgr. et Mgr. Filip Zlámal, Ph.D., učo 78448
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