B-cell activating factor (BAFF) – a new factor linking immunity to diet?

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Filip ZLÁMAL, Josef TOMANDL, Martin FOREJT, Marie TOMANDLOVÁ, Martin VAVŘINA, Jana KUDĚLKOVÁ, Zbyněk ŠPLÍCHAL and Anna VAŠKŮ. B-cell activating factor (BAFF) – a new factor linking immunity to diet? Central European Journal of Medicine. 2012, vol. 7, No 3, p. 275-283. ISSN 1895-1058. Available from: https://dx.doi.org/10.2478/s11536-011-0153-7.

Basic information

• Original name: B-cell activating factor (BAFF) – a new factor linking immunity to diet?
• Authors: BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Martin FOREJT (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Martin VAVŘINA (203 Czech Republic, belonging to the institution), Jana KUDĚLKOVÁ (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
• Edition: Central European Journal of Medicine, 2012, 1895-1058.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Poland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.262
• RIV identification code: RIV/00216224:14110/12:00060623
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.2478/s11536-011-0153-7
• UT WoS: 000304396200001
• Keywords in English: BAFF; Obesity; Dietary composition; Diet; Anthropometry
• Tags: International impact

Abstract

B cell activation factor (BAFF) is a recently discovered member of the TNF ligand superfamily secreted by adipocytes, previously linked to autoimmune and lymphoproliferative disease. The aim of this study was to investigate the relationship between BAFF plasma levels and the non-modified, usual dietary composition as well as obesity-related anthropometric parameters in a cohort of 58 obese and non-obese Central-European Caucasian individuals. We found that BAFF had an independent predictive role for percentage of body fat; moreover, BAFF levels were correlated with waist and hip circumference. BAFF plasma levels were also significantly correlated with investigated dietary composition based on the 7-day food records, as the BAFF levels correlated with the percentage of energy derived from the carbohydrates and with energy derived from the dietary fat. Our results suggest that BAFF may play a role in linking the immune status and metabolic response to diet.