Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings"

ŠPONER, Jiří, Claudio A MORGADO and Daniel SVOZIL. Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings". Journal of Physical Chemistry B. WASHINGTON: AMER CHEMICAL SOC, 2012, vol. 116, No 28, p. 8331-8332. ISSN 1520-6106. doi:10.1021/jp300659f.

Basic information

• Original name: Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings"
• Authors: ŠPONER, Jiří, Claudio A MORGADO and Daniel SVOZIL.
• Edition: Journal of Physical Chemistry B, WASHINGTON, AMER CHEMICAL SOC, 2012, 1520-6106.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10610 Biophysics
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.607
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1021/jp300659f
• UT WoS: 000306503000035
• Keywords in English: ACID BASE-PAIRS; STACKING ENERGIES; STABILITY; PARAMETERS; STEPS
• Tags: EDITORIAL, ok
• Tags: International impact, Reviewed

Abstract

Recently, Johnson et al.1 reported interesting quantumchemical computations on base stacking and base pairing energies in B-DNA and A-RNA. They deduced that “there most definitely is a quantitative correlation between the quantum mechanical gas-phase stacking data and nucleic acid stability”. Such conclusion is, in our opinion, too optimistic and oversimplified. We identified several issues questioning the validity of this statement.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GBP305/12/G034, research and development project: Name: Centrum biologie RNA