ŠPONER, Jiří, Claudio A MORGADO and Daniel SVOZIL. Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings". Journal of Physical Chemistry B. WASHINGTON: AMER CHEMICAL SOC, 2012, vol. 116, No 28, p. 8331-8332. ISSN 1520-6106. doi:10.1021/jp300659f.
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Basic information
Original name Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings"
Authors ŠPONER, Jiří, Claudio A MORGADO and Daniel SVOZIL.
Edition Journal of Physical Chemistry B, WASHINGTON, AMER CHEMICAL SOC, 2012, 1520-6106.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.607
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1021/jp300659f
UT WoS 000306503000035
Keywords in English ACID BASE-PAIRS; STACKING ENERGIES; STABILITY; PARAMETERS; STEPS
Tags EDITORIAL, ok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 28. 4. 2014 16:10.
Abstract
Recently, Johnson et al.1 reported interesting quantumchemical computations on base stacking and base pairing energies in B-DNA and A-RNA. They deduced that “there most definitely is a quantitative correlation between the quantum mechanical gas-phase stacking data and nucleic acid stability”. Such conclusion is, in our opinion, too optimistic and oversimplified. We identified several issues questioning the validity of this statement.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
GBP305/12/G034, research and development projectName: Centrum biologie RNA
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