Immunoregulatory T cells in multiple sclerosis and the effect
of interferon beta and glatiramer acetate treatment on T cell
subpopulations

J 2012

Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations

PRAKSOVÁ, Petra, Pavel ŠTOURAČ, Josef BEDNAŘÍK, Eva VLČKOVÁ, Zuzana MIKULKOVÁ et. al.

Basic information

Original name

Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations

Name in Czech

Imunoregulační T lymfocyty u roztroušené sklerózy a efekt léčby interferonem beta a glatiramer acetátem na dané T lymfocytární subpopulace

Authors

PRAKSOVÁ, Petra (203 Czech Republic), Pavel ŠTOURAČ (203 Czech Republic, guarantor, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Zuzana MIKULKOVÁ (203 Czech Republic, belonging to the institution) and Jaroslav MICHÁLEK (203 Czech Republic)

Edition

Journal of the Neurological Sciences, Amserdam, Elsevier, 2012, 0022-510X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30100 3.1 Basic medicine

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Full Text

Impact factor

Impact factor: 2.243

RIV identification code

RIV/00216224:14740/12:00060642

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.jns.2012.05.036

UT WoS

000306246900005

Keywords (in Czech)

centrální paměťové T lymfocyty; glatiramer acetát; interferon beta; roztroušená skleróza mozkomíšní; naivní T lymfocyty; regulační T lymfocyty

Keywords in English

central memory T cells; glatiramer acetate; interferon beta; multiple sclerosis; naive T cells; regulatory T cells

Abstract

ORIG CZ

V originále

The objective of this study was to evaluate T cells subpopulations among multiple sclerosis patients. We analyzed lymphocyte subpopulations in MS patients and healthy controls and studied the treatment effects of interferon beta and glatiramer acetate treatment on T cells subpopulations during first year of treatment in comparison with untreated patients. We observed a significant increase of effector T cells and decrease in regulatory T cells in MS patients compared to healthy controls. After glatiramer acetate and interferon beta therapy we observed a significant decrease in effector T cells and thus the restoration of imbalance in the immune system.

In Czech

Práce se zabývá subpopulacemi T lymfocytů u pacientů s roztroušenou sklerózou. Srovnáváme patofyziologicky relevantní lymfocytární populace u pacientů a zdravých kontrol a dále sledujeme vliv léčby interferonem beta a glatiramer acetátem na tyto subpopulace v průběhu prvního roku léčby ve srovnání s neléčenými pacienty. U pacientů s roztroušenou sklerózou nacházíme zvýšení efektorových subpopulací a naopak snížení regulačních lymfocytů ve srovnání se zdravými jedinci. Po léčbě glatiramer acetátem a interferonem beta pozorujeme snížení efektorových subpopulací T lymfocytů a tím obnovu nerovnováhy v imunitním systému.

Citovat

PRAKSOVÁ, Petra, Pavel ŠTOURAČ, Josef BEDNAŘÍK, Eva VLČKOVÁ, Zuzana MIKULKOVÁ and Jaroslav MICHÁLEK. Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations. Journal of the Neurological Sciences. Amserdam: Elsevier, 2012, vol. 319, 1-2, p. 18-23. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2012.05.036.

@article{989728,
   author = {Praksová, Petra and Štourač, Pavel and Bednařík, Josef and Vlčková, Eva and Mikulková, Zuzana and Michálek, Jaroslav},
   article_location = {Amserdam},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2012.05.036},
   keywords = {central memory T cells; glatiramer acetate; interferon beta; multiple sclerosis; naive T cells; regulatory T cells},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the Neurological Sciences},
   title = {Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations},
   url = {http://www.sciencedirect.com/science/article/pii/S0022510X1200264X},
   volume = {319},
   year = {2012}
}

TY  - JOUR
ID  - 989728
AU  - Praksová, Petra - Štourač, Pavel - Bednařík, Josef - Vlčková, Eva - Mikulková, Zuzana - Michálek, Jaroslav
PY  - 2012
TI  - Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations
JF  - Journal of the Neurological Sciences
VL  - 319
IS  - 1-2
SP  - 18-23
EP  - 18-23
PB  - Elsevier
SN  - 0022510X
KW  - central memory T cells
KW  - glatiramer acetate
KW  - interferon beta
KW  - multiple sclerosis
KW  - naive T cells
KW  - regulatory T cells
UR  - http://www.sciencedirect.com/science/article/pii/S0022510X1200264X
L2  - http://www.sciencedirect.com/science/article/pii/S0022510X1200264X
N2  - The objective of this study was to evaluate T cells subpopulations among multiple sclerosis patients. We analyzed lymphocyte subpopulations in MS patients and healthy controls and studied the treatment effects of interferon beta and glatiramer acetate treatment on T cells subpopulations during first year of treatment in comparison with untreated patients. We observed a significant increase of effector T cells and decrease in regulatory T cells in MS patients compared to healthy controls. After glatiramer acetate and interferon beta therapy we observed a significant decrease in effector T cells and thus the restoration of imbalance in the immune system.
ER  -

PRAKSOVÁ, Petra, Pavel ŠTOURAČ, Josef BEDNAŘÍK, Eva VLČKOVÁ, Zuzana MIKULKOVÁ and Jaroslav MICHÁLEK. Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations. \textit{Journal of the Neurological Sciences}. Amserdam: Elsevier, 2012, vol.~319, 1-2, p.~18-23. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2012.05.036.

Detailed Information on Publication Record