Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment

OGROCKÁ, Anna, Eva SÝKOROVÁ, Jiří FAJKUS and Miloslava FOJTOVÁ. Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. Journal of Experimental Botany. Oxford: OXFORD UNIV PRESS, 2012, vol. 63, No 11, p. 4233-4241. ISSN 0022-0957. Available from: https://dx.doi.org/10.1093/jxb/ers107.

Basic information

• Original name: Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment
• Authors: OGROCKÁ, Anna (203 Czech Republic, belonging to the institution), Eva SÝKOROVÁ (203 Czech Republic, belonging to the institution), Jiří FAJKUS (203 Czech Republic, belonging to the institution) and Miloslava FOJTOVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Experimental Botany, Oxford, OXFORD UNIV PRESS, 2012, 0022-0957.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.242
• RIV identification code: RIV/00216224:14740/12:00057105
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1093/jxb/ers107
• UT WoS: 000306686900021
• Keywords in English: Arabidopsis thaliana; developmental regulation; DNA methylation; histone modifications; telomerase
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

elomerase is precisely regulated during development and in animals, involvement of the epigenetic mechanisms to the regulation of the telomerase reverse transcriptase (TERT) gene transcription was reported. In Arabidopsis thaliana model plant, low level of methylated cytosines in the TERT upstream region was detected in both telomerase-positive and telomerase-negative tissues and AtTERT chromatin maintained the euchromatic nature despite the increased H3K27me3 loading in telomerase-negative tissue. These results may reflect a unique attribute of plants – their totipotency - which accords with a reversible and dynamic character of telomerase silencing.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GAP501/11/0596, research and development project: Name: Epigenetické mechanismy regulace rostlinných telomer (Acronym: epigenetika telomer)

Investor: Czech Science Foundation

• IAA500040801, research and development project: Name: Telomery a telomerázy: posun od molekulárně-biologického ke strukturně-biologickému přístupu.

Investor: Academy of Sciences of the Czech Republic, Telomeres and telomerase: transition from molecular to structural biology approach