Developmental silencing of the AtTERT gene is associated with
increased H3K27me3 loading and maintenance of its euchromatic
environment

J 2012

Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment

OGROCKÁ, Anna; Eva SÝKOROVÁ; Jiří FAJKUS and Miloslava FOJTOVÁ

Basic information

Original name

Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment

Authors

OGROCKÁ, Anna (203 Czech Republic, belonging to the institution); Eva SÝKOROVÁ (203 Czech Republic, belonging to the institution); Jiří FAJKUS (203 Czech Republic, belonging to the institution) and Miloslava FOJTOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Experimental Botany, Oxford, OXFORD UNIV PRESS, 2012, 0022-0957

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 5.242

RIV identification code

RIV/00216224:14740/12:00057105

Organization unit

Central European Institute of Technology

DOI

https://doi.org/10.1093/jxb/ers107

UT WoS

000306686900021

Keywords in English

Arabidopsis thaliana; developmental regulation; DNA methylation; histone modifications; telomerase

Abstract

In the original language

elomerase is precisely regulated during development and in animals, involvement of the epigenetic mechanisms to the regulation of the telomerase reverse transcriptase (TERT) gene transcription was reported. In Arabidopsis thaliana model plant, low level of methylated cytosines in the TERT upstream region was detected in both telomerase-positive and telomerase-negative tissues and AtTERT chromatin maintained the euchromatic nature despite the increased H3K27me3 loading in telomerase-negative tissue. These results may reflect a unique attribute of plants – their totipotency - which accords with a reversible and dynamic character of telomerase silencing.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP501/11/0596, research and development project

Name: Epigenetické mechanismy regulace rostlinných telomer (Acronym: epigenetika telomer)

Investor: Czech Science Foundation

IAA500040801, research and development project

Name: Telomery a telomerázy: posun od molekulárně-biologického ke strukturně-biologickému přístupu.

Investor: Academy of Sciences of the Czech Republic, Telomeres and telomerase: transition from molecular to structural biology approach

Cite

OGROCKÁ, Anna; Eva SÝKOROVÁ; Jiří FAJKUS and Miloslava FOJTOVÁ. Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. Journal of Experimental Botany. Oxford: OXFORD UNIV PRESS, 2012, vol. 63, No 11, p. 4233-4241. ISSN 0022-0957. Available from: https://doi.org/10.1093/jxb/ers107.

@article{990384,
   author = {Ogrocká, Anna and Sýkorová, Eva and Fajkus, Jiří and Fojtová, Miloslava},
   article_location = {Oxford},
   article_number = {11},
   doi = {https://doi.org/10.1093/jxb/ers107},
   keywords = {Arabidopsis thaliana; developmental regulation; DNA methylation; histone modifications; telomerase},
   language = {eng},
   issn = {0022-0957},
   journal = {Journal of Experimental Botany},
   title = {Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment},
   url = {http://jxb.oxfordjournals.org/content/63/11/4233},
   volume = {63},
   year = {2012}
}

TY  - JOUR
ID  - 990384
AU  - Ogrocká, Anna - Sýkorová, Eva - Fajkus, Jiří - Fojtová, Miloslava
PY  - 2012
TI  - Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment
JF  - Journal of Experimental Botany
VL  - 63
IS  - 11
SP  - 4233-4241
EP  - 4233-4241
PB  - OXFORD UNIV PRESS
SN  - 00220957
KW  - Arabidopsis thaliana
KW  - developmental regulation
KW  - DNA methylation
KW  - histone modifications
KW  - telomerase
UR  - http://jxb.oxfordjournals.org/content/63/11/4233
L2  - http://jxb.oxfordjournals.org/content/63/11/4233
N2  - elomerase is precisely regulated during development and in animals, involvement of the epigenetic mechanisms to the regulation of the telomerase reverse transcriptase (TERT) gene transcription was reported. In Arabidopsis thaliana model plant, low level of methylated cytosines in the TERT upstream region was detected in both telomerase-positive and telomerase-negative tissues and AtTERT chromatin maintained the euchromatic nature despite the increased H3K27me3 loading in telomerase-negative tissue. These results may reflect a unique attribute of plants – their totipotency - which accords with a reversible and dynamic character of telomerase silencing.
ER  -

OGROCKÁ, Anna; Eva SÝKOROVÁ; Jiří FAJKUS and Miloslava FOJTOVÁ. Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. \textit{Journal of Experimental Botany}. Oxford: OXFORD UNIV PRESS, 2012, vol.~63, No~11, p.~4233-4241. ISSN~0022-0957. Available from: https://doi.org/10.1093/jxb/ers107.

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