HMGB1 gene knockout in mouse embryonic fibroblasts results in
reduced telomerase activity and telomere dysfunction

J 2012

HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction

POLANSKÁ, Eva, Zuzana DOBŠÁKOVÁ, Martina DVOŘÁČKOVÁ, Jiří FAJKUS, Michal ŠTROS et. al.

Basic information

Original name

HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction

Authors

POLANSKÁ, Eva (203 Czech Republic), Zuzana DOBŠÁKOVÁ (203 Czech Republic, belonging to the institution), Martina DVOŘÁČKOVÁ (203 Czech Republic, belonging to the institution), Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution) and Michal ŠTROS (203 Czech Republic)

Edition

Chromosoma, New York, Springer, 2012, 0009-5915

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.340

RIV identification code

RIV/00216224:14740/12:00057107

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s00412-012-0373-x

UT WoS

000306695800008

Keywords in English

REPEAT AMPLIFICATION PROTOCOL; CHROMOSOMAL-PROTEIN HMG1; DNA-DAMAGE; CHROMATIN; MAINTENANCE; BINDING; EXPRESSION; COMPLEXES; GENOME; GROWTH

Abstract

V originále

Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellular activity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP305/12/2475, research and development project

Name: Proteiny HMGB: funkce v biologii telomer a lidských embryonálních kmenových buněk

Investor: Czech Science Foundation

IAA500040801, research and development project

Name: Telomery a telomerázy: posun od molekulárně-biologického ke strukturně-biologickému přístupu.

Investor: Academy of Sciences of the Czech Republic, Telomeres and telomerase: transition from molecular to structural biology approach

Citovat

POLANSKÁ, Eva, Zuzana DOBŠÁKOVÁ, Martina DVOŘÁČKOVÁ, Jiří FAJKUS and Michal ŠTROS. HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. Chromosoma. New York: Springer, 2012, vol. 121, No 4, p. 419-431. ISSN 0009-5915. Available from: https://dx.doi.org/10.1007/s00412-012-0373-x.

@article{990390,
   author = {Polanská, Eva and Dobšáková, Zuzana and Dvořáčková, Martina and Fajkus, Jiří and Štros, Michal},
   article_location = {New York},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s00412-012-0373-x},
   keywords = {REPEAT AMPLIFICATION PROTOCOL; CHROMOSOMAL-PROTEIN HMG1; DNA-DAMAGE; CHROMATIN; MAINTENANCE; BINDING; EXPRESSION; COMPLEXES; GENOME; GROWTH},
   language = {eng},
   issn = {0009-5915},
   journal = {Chromosoma},
   title = {HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction},
   url = {http://link.springer.com/article/10.1007%2Fs00412-012-0373-x},
   volume = {121},
   year = {2012}
}

TY  - JOUR
ID  - 990390
AU  - Polanská, Eva - Dobšáková, Zuzana - Dvořáčková, Martina - Fajkus, Jiří - Štros, Michal
PY  - 2012
TI  - HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
JF  - Chromosoma
VL  - 121
IS  - 4
SP  - 419-431
EP  - 419-431
PB  - Springer
SN  - 00095915
KW  - REPEAT AMPLIFICATION PROTOCOL
KW  - CHROMOSOMAL-PROTEIN HMG1
KW  - DNA-DAMAGE
KW  - CHROMATIN
KW  - MAINTENANCE
KW  - BINDING
KW  - EXPRESSION
KW  - COMPLEXES
KW  - GENOME
KW  - GROWTH
UR  - http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
L2  - http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
N2  - Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellular activity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.
ER  -

POLANSKÁ, Eva, Zuzana DOBŠÁKOVÁ, Martina DVOŘÁČKOVÁ, Jiří FAJKUS and Michal ŠTROS. HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. \textit{Chromosoma}. New York: Springer, 2012, vol.~121, No~4, p.~419-431. ISSN~0009-5915. Available from: https://dx.doi.org/10.1007/s00412-012-0373-x.

Detailed Information on Publication Record