| POLANSKÁ, Eva, Zuzana DOBŠÁKOVÁ, Martina DVOŘÁČKOVÁ, Jiří FAJKUS and Michal ŠTROS. HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. Chromosoma. New York: Springer, 2012, vol. 121, No 4, p. 419-431. ISSN 0009-5915. Available from: https://dx.doi.org/10.1007/s00412-012-0373-x. |
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@article{990390,
author = {Polanská, Eva and Dobšáková, Zuzana and Dvořáčková, Martina and Fajkus, Jiří and Štros, Michal},
article_location = {New York},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s00412-012-0373-x},
keywords = {REPEAT AMPLIFICATION PROTOCOL; CHROMOSOMAL-PROTEIN HMG1; DNA-DAMAGE; CHROMATIN; MAINTENANCE; BINDING; EXPRESSION; COMPLEXES; GENOME; GROWTH},
language = {eng},
issn = {0009-5915},
journal = {Chromosoma},
title = {HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction},
url = {http://link.springer.com/article/10.1007%2Fs00412-012-0373-x},
volume = {121},
year = {2012}
}
TY - JOUR
ID - 990390
AU - Polanská, Eva - Dobšáková, Zuzana - Dvořáčková, Martina - Fajkus, Jiří - Štros, Michal
PY - 2012
TI - HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
JF - Chromosoma
VL - 121
IS - 4
SP - 419-431
EP - 419-431
PB - Springer
SN - 00095915
KW - REPEAT AMPLIFICATION PROTOCOL
KW - CHROMOSOMAL-PROTEIN HMG1
KW - DNA-DAMAGE
KW - CHROMATIN
KW - MAINTENANCE
KW - BINDING
KW - EXPRESSION
KW - COMPLEXES
KW - GENOME
KW - GROWTH
UR - http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
L2 - http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
N2 - Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellular activity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.
ER -
POLANSKÁ, Eva, Zuzana DOBŠÁKOVÁ, Martina DVOŘÁČKOVÁ, Jiří FAJKUS and Michal ŠTROS. HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. \textit{Chromosoma}. New York: Springer, 2012, vol.~121, No~4, p.~419-431. ISSN~0009-5915. Available from: https://dx.doi.org/10.1007/s00412-012-0373-x.
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