NOVOTNÝ, Tomáš, Jiří JEŘÁBEK, Karel VESELÝ, Robert STAFFA, Martin DVOŘÁK a Jan CAGAŠ. Evaluation of a knitted polytetrafluoroethylene mesh placed intraperitoneally in a New Zealand white rabbit model. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES. NEW YORK: SPRINGER, 2012, roč. 26, č. 7, s. 1884-1891. ISSN 0930-2794. doi:10.1007/s00464-011-2120-4.
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Základní údaje
Originální název Evaluation of a knitted polytetrafluoroethylene mesh placed intraperitoneally in a New Zealand white rabbit model
Autoři NOVOTNÝ, Tomáš (203 Česká republika, garant, domácí), Jiří JEŘÁBEK (203 Česká republika, domácí), Karel VESELÝ (203 Česká republika, domácí), Robert STAFFA (203 Česká republika, domácí), Martin DVOŘÁK (203 Česká republika, domácí) a Jan CAGAŠ (203 Česká republika, domácí).
Vydání SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, NEW YORK, SPRINGER, 2012, 0930-2794.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30200 3.2 Clinical medicine
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.427
Kód RIV RIV/00216224:14110/12:00060719
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1007/s00464-011-2120-4
UT WoS 000305214100013
Klíčová slova anglicky Adhesions; Biocompatibility; Hernia; Knitted PTFE; Mesh; Polypropylene
Příznaky Mezinárodní význam
Změnil Změnil: Mgr. Michal Petr, učo 65024. Změněno: 3. 9. 2012 11:15.
Anotace
Background The intraperitoneal application of surgical mesh remains a controversial issue because of possible complications, especially adhesion and fistula formation. This study aimed to assess the potential of a knitted polytetrafluoroethylene (PTFE) mesh for intraabdominal implantation. Methods Twenty-eight 5 x 5 cm samples of knitted macroporous PTFE mesh and light-weight polypropylene mesh (LW-PP) were implanted intraperitoneally in 14 New Zealand white rabbits in a randomized manner and fixed using eight polypropylene stitches. After 90 days, the adhesion formation, adhesion score, shrinkage, strength of fixation to the abdominal wall, and histologic biocompatibility were assessed. Results No intraoperative or anesthesia-related complications or mesh infection were recorded. The average area covered by adhesions was 4.7 +/- 7.2% for the PTFE and 36.4 +/- 36.1% for the LW-PP. The median adhesion score was 0 for the PTFE and 8 for the LW-PP. Shrinkage was 36.9 +/- 12.9% for the PTFE mesh and 12.6 +/- 8.72% for the LW-PP. The mesh-to-abdominal wall fixation strength was almost the same for both materials (PTFE 3.6 +/- 1.9 vs. LW-PP 3.6 +/- 2.9). The inflammatory cell count was almost the same for the two groups, with no statistically significant difference. The width of the inner granuloma was equal (PTFE 10.5 +/- 0.9 vs. LW-PP 11.1 +/- 0.9). The outer granuloma was reduced significantly in the PTFE group (PTFE 23.0 +/- 2.1 vs. LW-PP 33.6 +/- 7.9). One of the animals in the PTFE group died on postoperative day 12 because of ileus. The reason was an adhesion of the small intestine to the polypropylene fixation stitch, which caused small intestine strangulation. Conclusions The knitted PTFE mesh induces fewer intraperitoneal adhesions of lower density than the light-weight polypropylene mesh. The strength of the knitted PTFE mesh fixation to the abdominal wall is comparable with that of the light-weight polypropylene mesh, but the shrinkage is greater. The biocompatibility of the knitted PTFE mesh is comparable with that of the light-weight polypropylene implant.
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