HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. European Journal of Medical Research. London: Biomed Central, 2012, vol. 17, Jun, p. "nestránkováno", 5 pp. ISSN 0949-2321. Available from: https://dx.doi.org/10.1186/2047-783X-17-17. |
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@article{991016, author = {Héžová, Renata and Bienertová Vašků, Julie and Šachlová, Milana and Březková, Veronika and Vašků, Anna and Svoboda, Marek and Radová, Lenka and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej}, article_location = {London}, article_number = {Jun}, doi = {http://dx.doi.org/10.1186/2047-783X-17-17}, keywords = {Colorectal cancer; GSTA1; GSTT1; GSTM1; GSTP1; Polymorphism}, language = {eng}, issn = {0949-2321}, journal = {European Journal of Medical Research}, title = {Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population}, url = {http://ww.eurjmedres.com/content/17/1/17}, volume = {17}, year = {2012} }
TY - JOUR ID - 991016 AU - Héžová, Renata - Bienertová Vašků, Julie - Šachlová, Milana - Březková, Veronika - Vašků, Anna - Svoboda, Marek - Radová, Lenka - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej PY - 2012 TI - Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population JF - European Journal of Medical Research VL - 17 IS - Jun SP - "nestránkováno" EP - "nestránkováno" PB - Biomed Central SN - 09492321 KW - Colorectal cancer KW - GSTA1 KW - GSTT1 KW - GSTM1 KW - GSTP1 KW - Polymorphism UR - http://ww.eurjmedres.com/content/17/1/17 L2 - http://ww.eurjmedres.com/content/17/1/17 N2 - Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione Stransferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics. In this study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction. ER -
HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. \textit{European Journal of Medical Research}. London: Biomed Central, 2012, vol.~17, Jun, p.~''nestránkováno'', 5 pp. ISSN~0949-2321. Available from: https://dx.doi.org/10.1186/2047-783X-17-17.
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