Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and
susceptibility to colorectal cancer in the Central European
population

J 2012

Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population

HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ et. al.

Basic information

Original name

Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population

Authors

HÉŽOVÁ, Renata (203 Czech Republic), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Milana ŠACHLOVÁ (203 Czech Republic), Veronika BŘEZKOVÁ (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic), Lenka RADOVÁ (203 Czech Republic), Igor KISS (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Journal of Medical Research, London, Biomed Central, 2012, 0949-2321

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.098

RIV identification code

RIV/00216224:14740/12:00060774

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1186/2047-783X-17-17

UT WoS

000311309100001

Keywords in English

Colorectal cancer; GSTA1; GSTT1; GSTM1; GSTP1; Polymorphism

Abstract

V originále

Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione Stransferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics. In this study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. European Journal of Medical Research. London: Biomed Central, 2012, vol. 17, Jun, p. "nestránkováno", 5 pp. ISSN 0949-2321. Available from: https://dx.doi.org/10.1186/2047-783X-17-17.

@article{991016,
   author = {Héžová, Renata and Bienertová Vašků, Julie and Šachlová, Milana and Březková, Veronika and Vašků, Anna and Svoboda, Marek and Radová, Lenka and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {London},
   article_number = {Jun},
   doi = {http://dx.doi.org/10.1186/2047-783X-17-17},
   keywords = {Colorectal cancer; GSTA1; GSTT1; GSTM1; GSTP1; Polymorphism},
   language = {eng},
   issn = {0949-2321},
   journal = {European Journal of Medical Research},
   title = {Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population},
   url = {http://ww.eurjmedres.com/content/17/1/17},
   volume = {17},
   year = {2012}
}

TY  - JOUR
ID  - 991016
AU  - Héžová, Renata - Bienertová Vašků, Julie - Šachlová, Milana - Březková, Veronika - Vašků, Anna - Svoboda, Marek - Radová, Lenka - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population
JF  - European Journal of Medical Research
VL  - 17
IS  - Jun
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Biomed Central
SN  - 09492321
KW  - Colorectal cancer
KW  - GSTA1
KW  - GSTT1
KW  - GSTM1
KW  - GSTP1
KW  - Polymorphism
UR  - http://ww.eurjmedres.com/content/17/1/17
L2  - http://ww.eurjmedres.com/content/17/1/17
N2  - Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione Stransferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics. In this study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.
ER  -

HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. \textit{European Journal of Medical Research}. London: Biomed Central, 2012, vol.~17, Jun, p.~''nestránkováno'', 5 pp. ISSN~0949-2321. Available from: https://dx.doi.org/10.1186/2047-783X-17-17.

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