Alleviation of extrapyramidal side effects upon switching from risperidone to paliperidone

PŘIKRYL, Radovan. Alleviation of extrapyramidal side effects upon switching from risperidone to paliperidone. Activitas Nervosa Superior Rediviva. Praha: Collegium Internationale Activitatis N.S, vol. 53, No 1, p. 14-16. ISSN 1337-933X. 2011.

Basic information

• Original name: Alleviation of extrapyramidal side effects upon switching from risperidone to paliperidone
• Authors: PŘIKRYL, Radovan (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Activitas Nervosa Superior Rediviva, Praha, Collegium Internationale Activitatis N.S, 2011, 1337-933X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14740/11:00060845
• Organization unit: Central European Institute of Technology
• Keywords in English: case report; clinical experience; extrapyr amidal side effects; paliperidone; treatment
• Tags: ok, rivok

Abstract

Paliperidone is a new second generation antipsychotic; in terms of pharmacology, it is an active metabolite of risperidone. Compared to risperidone, paliperidone should thus show more stable occupation of dopamine receptors in the brain, which on one the hand may lead to increased antipsychotic efficacy, and on the other hand to reduced incidence of adverse extrapyramidal effects. The case report describes alleviation of Parkinson’s syndrome induced by risperidone by switching to paliperidone in a young man with a new occurrence of a paranoid schizophrenia episode. Thanks to its clinical efficacy, paliperi- done is ranked among the most successful second generation antipsychotics with reduced extrapyramidal symptomatology

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.