BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION

k 2012

BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION

IONESCU, Crina-Maria, Zuzana KLÍMOVÁ, David SEHNAL, Radka SVOBODOVÁ VAŘEKOVÁ, Jaroslav KOČA et. al.

Basic information

Original name

BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION

Authors

IONESCU, Crina-Maria, Zuzana KLÍMOVÁ, David SEHNAL, Radka SVOBODOVÁ VAŘEKOVÁ and Jaroslav KOČA

Edition

XXIII. biochemický sjezd České společnosti pro biochemii a molekulární biologii a Slovenské spoločnosti pre biochémiu a molekulárnu biológiu, 2012

Other information

Type of outcome

Prezentace na konferencích

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords in English

apoptosis, BH3 domain

Změněno: 12/4/2024 14:18, Mgr. Marie Šípková, DiS.

Abstract

V originále

Disfunctions in the mechanism of programmed cell death (apoptosis) are directly related to cancer, neurodegenerative and auto-immune diseases. Apoptosis is highly regulated by the interplay of BH3-only proteins [1,2]. How these proteins perform their function at the molecular level is not yet understood, which makes it very hard to develop medical treatment. We recently developed SiteBinder, an effective tool for comparing the 3D structure of multiple protein motifs [3]. Using this tool, we performed a brief structural comparison of the BH3 domain of several BH3-only proteins known to promote cell death. The preliminary results showed that there is a detectable structural trend which correlates with the type of mechanism of action (direct versus indirect) of these proteins. We present here our results of an extensive structural comparison analysis comprising all BH3-only proteins whose structure is known. Our investigations were ultimately meant to determine whether the measures of 3D structural similarity correlate with specificity of binding. The results of our analysis can be useful in studies focused on modulating apoptosis and related diseases.

Links

GD301/09/H004, research and development project

Name: Molekulární a strukturní biologie vybraných cytostatik. Od mechanistických studií k chemoterapii rakoviny

Investor: Czech Science Foundation

MUNI/A/0914/2009, interní kód MU

Name: Rozsáhlé výpočetní systémy: modely, aplikace a verifikace (Acronym: SV-FI MAV)

Investor: Masaryk University, Category A

Citovat

IONESCU, Crina-Maria, Zuzana KLÍMOVÁ, David SEHNAL, Radka SVOBODOVÁ VAŘEKOVÁ and Jaroslav KOČA. BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION. In XXIII. biochemický sjezd České společnosti pro biochemii a molekulární biologii a Slovenské spoločnosti pre biochémiu a molekulárnu biológiu. 2012.

@proceedings{992730,
   author = {Ionescu, CrinaandMaria and Klímová, Zuzana and Sehnal, David and Svobodová Vařeková, Radka and Koča, Jaroslav},
   booktitle = {XXIII. biochemický sjezd České společnosti pro biochemii a molekulární biologii a Slovenské spoločnosti pre biochémiu a molekulárnu biológiu},
   keywords = {apoptosis, BH3 domain},
   title = {BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION},
   year = {2012}
}

TY  - CONF
ID  - 992730
AU  - Ionescu, Crina-Maria - Klímová, Zuzana - Sehnal, David - Svobodová Vařeková, Radka - Koča, Jaroslav
PY  - 2012
TI  - BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION
KW  - apoptosis, BH3 domain
N2  - Disfunctions in the mechanism of programmed cell death (apoptosis) are directly related to cancer, neurodegenerative and auto-immune diseases. Apoptosis is highly regulated by the interplay of BH3-only proteins [1,2]. How these proteins perform their function at the molecular level is not yet understood, which makes it very hard to develop medical treatment. We recently developed SiteBinder, an effective tool for comparing the 3D structure of multiple protein motifs [3]. Using this tool, we performed a brief structural comparison of the BH3 domain of several BH3-only proteins known to promote cell death. The preliminary results showed that there is a detectable structural trend which correlates with the type of mechanism of action (direct versus indirect) of these proteins. We present here our results of an extensive structural comparison analysis comprising all BH3-only proteins whose structure is known. Our investigations were ultimately meant to determine whether the measures of 3D structural similarity correlate with specificity of binding. The results of our analysis can be useful in studies focused on modulating apoptosis and related diseases.
ER  -

IONESCU, Crina-Maria, Zuzana KLÍMOVÁ, David SEHNAL, Radka SVOBODOVÁ VAŘEKOVÁ and Jaroslav KOČA. BH3-ONLY PROTEINS - FROM STRUCTURE TO FUNCTION. In \textit{XXIII. biochemický sjezd České společnosti pro biochemii a molekulární biologii a Slovenské spoločnosti pre biochémiu a molekulárnu biológiu}. 2012.

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