KREJČÍ, Marta, Jan KAMELANDER, Zdeněk POSPÍŠIL and Jiří MAYER. Kinetics of bilirubin and liver enzymes is useful for predicting of liver graft-versus-host disease. Neoplasma. BRASTISLAVA, 2012, vol. 59, No 3, p. 264-268. ISSN 0028-2685. doi:10.4149/neo_2012_034.
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Basic information
Original name Kinetics of bilirubin and liver enzymes is useful for predicting of liver graft-versus-host disease
Authors KREJČÍ, Marta (203 Czech Republic, guarantor, belonging to the institution), Jan KAMELANDER (203 Czech Republic, belonging to the institution), Zdeněk POSPÍŠIL (203 Czech Republic, belonging to the institution) and Jiří MAYER (203 Czech Republic, belonging to the institution).
Edition Neoplasma, BRASTISLAVA, 2012, 0028-2685.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.574
RIV identification code RIV/00216224:14110/12:00060967
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.4149/neo_2012_034
UT WoS 000301966700004
Keywords in English liver GVHD; kinetics; bilirubin; liver enzymes
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 19. 9. 2012 10:31.
Abstract
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic cell transplantation. We analyzed the kinetics of bilirubin and liver enzymes in 47 cases with liver GVHD and in 47 cases without GVHD after allogeneic transplantation for various hematological malignancies. The duration of an liver GVHD episode (LGVHD) was defined as the interval from the point when the criteria of LGVHD were met to the decrease to < 2 upper normal limit (UNL) for aminotransferases or bilirubin < 34 mu mol/l for bilirubin. The imminent LGVHD episode was defined as the interval from the start of continuous increase (>= 3 consecutive rising values) of bilirubin and liver enzymes above UNL to the point of LGVHD diagnosis. The number of imminent LGVHD episodes, and median length in days were as follows: bilirubin (39;5), ALT(28;12), AST(9;12), GGTP(34;9), and ALP(13;14). Statisticallly significant associations between asymptomatic continuous increase of bilirubin, ALT, and GGTP and later liver GVHD manifestation were found (p=0.004, p=0.008, p=0.005, respectively). The asymptomatic continuous increase in bilirubin, ALT, and GGTP occurred at a median of 5, 12, and 9 days before liver GVHD episode, respectively. In the control group without GVHD, median levels of bilirubin and liver enzymes were within normal limits and no continuous increase was observed. Kinetics of bilirubin and liver enzymes is useful for predicting of liver GVHD. A continuous increase of bilirubin and/or ALT, GGTP before the standard liver GVHD criteria are met can be a sign of coming liver GVHD.
Links
MSM0021622430, plan (intention)Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Research Intents
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