Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission

@article{1357230,
   author = {Shyamsunder, Pavithra and Ešner, Milan and Barvalia, Maunish and Wu, Yu Jun and Loja, Tomáš and Boon, Huat Bay and Lleonart, Matilde E. and Verma, Rama S and Krejčí, Lumír and Lyakhovich, Alex},
   article_location = {New York},
   article_number = {36},
   doi = {http://dx.doi.org/10.18632/oncotarget.11161},
   keywords = {mitophagy; impaired autophagy; Fanconi anemia; ROS; oxidative stress},
   language = {eng},
   issn = {1949-2553},
   journal = {Oncotarget},
   title = {Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission},
   volume = {7},
   year = {2016}
}

TY  - JOUR
ID  - 1357230
AU  - Shyamsunder, Pavithra - Ešner, Milan - Barvalia, Maunish - Wu, Yu Jun - Loja, Tomáš - Boon, Huat Bay - Lleonart, Matilde E. - Verma, Rama S - Krejčí, Lumír - Lyakhovich, Alex
PY  - 2016
TI  - Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
JF  - Oncotarget
VL  - 7
IS  - 36
SP  - 58065-58074
EP  - 58065-58074
PB  - Impact Journals
SN  - 19492553
KW  - mitophagy
KW  - impaired autophagy
KW  - Fanconi anemia
KW  - ROS
KW  - oxidative stress
N2  - Fanconi anemia (FA) is a rare genetic disorder associated with bone-marrow failure, genome instability and cancer predisposition. Recently, we and others have demonstrated dysfunctional mitochondria with morphological alterations in FA cells accompanied by high reactive oxygen species (ROS) levels. Mitochondrial morphology is regulated by continuous fusion and fission events and the misbalance between these two is often accompanied by autophagy. Here, we provide evidence of impaired autophagy in FA. We demonstrate that FA cells have increased number of autophagic (presumably mitophagic) events and accumulate dysfunctional mitochondria due to an impaired ability to degrade them. Moreover, mitochondrial fission accompanied by oxidative stress (OS) is a prerequisite condition for mitophagy in FA and blocking this pathway may release autophagic machinery to clear dysfunctional mitochondria.
ER  - 

SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA, Huat Bay BOON, Matilde E. LLEONART, Rama S VERMA, Lumír KREJČÍ a Alex LYAKHOVICH. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. Online. \textit{Oncotarget}. New York: Impact Journals, 2016, roč.~7, č.~36, s.~58065-58074. ISSN~1949-2553. Dostupné z: https://dx.doi.org/10.18632/oncotarget.11161. [citováno 2024-04-23]