Vyhledávání publikací

Vybrané publikace/výsledky

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2 (2007)
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors (2007)
Structure-guided discovery of cyclin-dependent kinase inhibitors (2008)
Novel modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors (2009)
2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors (2009)
Synthesis of Substituted 3-Aminopyrazoles (2008)
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors (2008)
Novel pyrazolopyrimidines as novel cyćlin dependent kinase inhibitors (2008)
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors (2008)
Imidazopyrazines as protein kinase inhibitors (2007)
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors (2007)
Imidazopyrazines as protein kinase inhibitors (2007)
Methods for inhibiting protein kinases (2007)
Pyrazolopyrimidines as protein kinase inhibitors (2007)
Pyrazolopyrimidines as protein kinase inhibitors (2007)
Methods for inhibiting protein kinases (2007)
Pyrazolopyrimidines as protein kinase inhibitors (2007)
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors (2007)
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors (2007)
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors (2007)
Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds (2007)
Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2006)
Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors (2006)
Pyrazolopyrimidines as Protein Kinase Inhibitors (2006)
Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2006)
Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2006)
Pyrazolotriazines as Kinase Inhibitors (2005)
Pyrazolopyrimidines as cyclin-dependent kinase inhibitors (2004)
Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors (2004)
Imidazopyridines as Cyclin Dependent Kinase Inhibitors (2004)
Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors (2004)
Imidazopyrazines as Cyclin Dependent Kinase Inhibitors (2004)
Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2004)
Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2004)
Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2004)
Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2004)
Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (2004)
17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors (2004)
Piperidine- and Piperazineacetamides as 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors for the Treatment of Androgen Dependent Diseases (2003)
17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors for the Treatment of Androgen Dependent Diseases (2003)
Functionalizations of [6]- and [7]helicenes at their most sterically hindered positions (2003)
Acidified Alcohols as Agents to Introduce and Exchange Alkoxyls on the Periphery of Helicenes (2000)
Why (1S)-Camphanates Are Excellent Resolving Agents for Helicen-1-ols and Why They Can Be Used to Analyze Absolute Configurations (2000)
First Friedel-Crafts Diacylation of a Phenanthrene as the Basis for an Efficient Synthesis of Nonracemic [7]Helicenes (2000)
Expeditious Procedure To Synthesize Ethers and Esters of Tri- and Tetrahydroxy[6]helicenebisquinones from the Dye-Intermediates Disodium 4-Hydroxy- and 4,5-Dihydroxynaphthalene-2,7-disulfonates (2000)
Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases. (2010)
Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor (2010)
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. (2011)
IVth Conference on Heterocycles in Bio-organic Chemistry - Bioheterocycles 2011 (2011)
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2. (2011)
Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening (2011)
Inhibice kinázy Chk1 senzitivuje buňky leukemií a lymfomů s mutacemi p53 na chemoterapeutika (2012)
Cyclin-dependent kinase Inhibitors Inspired by Roscovitine: Purine Bioisosteres (2012)
Inhibition of Chk1 kinase sensitizes leukemia and lymphoma cell lines with TP53 mutations to chemotherapy (2012)
Quantum Mechanical Scoring: Structural and Energetic Insights into Cyclin-Dependent Kinase 2 Inhibition by Pyrazolo[1,5-a]pyrimidines (2013)
Synthetic lethality in p53 mutated B-cell mylignancies: Chk-1 inhibition and DNA-PK inhibition effect in cell lines and primary CLL cells (2013)
Are Time-Dependent Fluorescence Shifts at the Tunnel Mouth of Haloalkane Dehalogenase Enzymes Dependent on the Choice of the Chromophore? (2013)
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach (2013)
Syntheses of 5´-amino-2´,5´-dideoxy-2´,2´-difluorocytidine derivatives as novel anticancer nucleoside analogs (2014)
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs (2014)
Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress (2014)
Is checkpoint kinase 1 a suitable molecular target for combination with cancer chemotherapeutics? (2014)
Is checkpoint kinase 1 a suitable molecular target for sensitization of TP53-mutated leukemia and lymphoma cells to chemotherapy? (2014)
Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence. (2015)
Synthesis of carbocyclic analogs of dehydroaltenusin: identification of a stable inhibitor of calf DNA polymerase a (2015)
Nanostructured surface modifications for stem cell studie (2014)
Chronic lymphocytic leukemia cells are highly susceptible to direct inhibition of checkpoint kinase (2015)
Substituované furo[3,2-b]pyridiny pro použití jako léčiva (2015)
Nanostructured surfaces for studying the cellular interactions (2015)
Nanostrukturovaný povrch pro studium mezibuněčných interakcí kmenových buněk (2015)
Nanostructured surfaces as a promising tool for studying the cellular interactions (2015)
Novel approach for studying of cell interactions via nanostructured surfaces (2015)
Preparation of nanostructured molecular lawn as tool for studying the cellular interactions (2015)
Nanostrukturování povrchů jako slibný nástroj pro studium buněčných interakcí kmenových buněk (2016)
Development and validation of a highly sensitive LC-MS method for determination of checkpoint kinase 1 inhibitors in mouse plasma (2016)
Late-stage annulative convergency in natural product synthesis (2016)
Nanostructured Surfaces for Studying the Cellular Interactions (2016)
Nanostructured molecular lawn-powerful tool for studying cellular interactions (2016)
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells (2016)
Checkpoint kinase 1 inhibition potentiates apoptosis and inflicts mitotic failure in CLL-derived MEC-1 cell line. (2016)
Inhibition of Chk1 enhances colon cancer cell sensitivity to apoptosis induced by platinum (IV) complex LA-12. (2016)
Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines (2017)
Direct nanopatterning of biomolecules by electron beam lithography for studying of cellular interaction (2017)
Diastereoselective Flexible Synthesis of Carbocyclic C Nucleosides (2017)
Potenciál inhibice proteinu Chk1 u chronické lymfocytární leukémie s mutacemi v genu TP53. (2017)
Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles (2017)
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation (2017)
Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells (2017)
A Concise Synthesis of Forskolin (2017)
BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors (2017)
The role of Chk1 in regulation of apoptosis induced by platinum-based drugs in human prostate cancer cells (2017)
INHIBITION OF CHK1 STIMULATES THE COOPERATIVE CYTOTOXIC ACTION OF PLATINUM-BASED DRUGS AND TRAIL IN HUMAN PROSTATE CANCER CELLS (2017)
Flow cytometric analysis of nucleoside transporters activity (2017)
Pyrazolotriazines as inhibitors of nucleases (2017)
ATR-Chk1 pathway as a therapeutic target for leukemia and lymphoma (2017)
Preparation of nanostructured surfaces to influence hPSC behavior (2018)
Kompletní analýza vlastností nových inhibitorů kasein kinázy 1 pro léčbu chronické lymfocytární leukémie (2017)
Impact of the access tunnel engineering on catalysis is strictly ligand-specific (2018)
Furopyridines as inhibitors of protein kinases (2018)
Pyrazolotriazines as inhibitors of nucleases (2018)
Inovativní inhibitor proteinu CHK1 indukuje apoptózu u buněk chronické lymfocytární leukémie s mutacemi v genu TP53 (2018)
Furopyridines as inhibitors of protein kinases (2018)
Selective CHK1 inhibitor MU380 exhibits single-agent activity against chronic lymphocytic leukemia cells with TP53 mutations (2018)
Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles (2018)
Pyrazolotriazines as inhibitors of nucleases (2018)
Development of selective casein kinase 1 delta/epsilon inhibitors for cancer (2018)
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway (2019)
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology (2019)
CDK12 kinase activity controls G1/S progression by regulating optimal transcription of core DNA replication genes (2018)
Identifikace nových účinných inhibitorů kináz CLK a HIPK s optimálním in vitro a in vivo profilem (2018)
Inhibition of Chk1 enhances cooperative anticancer action of platinum-based drugs and TRAIL via activation of mitochondrial apoptotic pathway (2019)
CHK1 INHIBITION FACILITATES THE COOPERATIVE ANTICANCER ACTION OF PLATINUM-BASED DRUGS AND TRAIL (2019)
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes (2019)
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells (2019)
Potenciál inhibice proteinu CHK1 u chronické lymfocytární leukemie s mutacemi v genu TP53 (2019)
ATR-CHK1 signaling is active and targetable in quiescent CLL cells (2019)
Potenciál inhibice proteinu checkpoint kinase 1 u chronické lymfocytární leukémie s mutacemi v genu TP53. (2019)
Cílená inhibice kasein kinázy 1 v léčbě chronické lymfoidní leukémie. (2019)
Nanopatterning Glass Surface For Localization Of Embryonic Stem Cells (2019)
Furopyridines as inhibitors of protein kinases (2020)
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe (2020)
Substituted propanamides as inhibitors of nucleases (2020)
Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential (2020)
4—(1h— imidazol— 5— yl) -1h-pyrrolo (2, 3-b) pyridines for use in the treatment of leukaemias, lymphomas and solid tumors (2021)
Cytoprotective activities of kinetin purine isosteres (2021)
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core (2021)
CHK1 INHIBITOR SCH900776 ENHANCES ANTICANCER ACTION OF CISPLATIN AND TRAIL VIA STIMULATION OF BAK-DEPENDENT MITOCHONDRIAL PATHWAY (2021)
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES (2021)
Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides (2022)
CDK11 regulates pre-mRNA splicing by phosphorylation ofSF3B1 (2022)
Geometric Control of Cell Behavior by Biomolecule Nanodistribution (2022)
Comparing the efficiency of six clearing methods in developing seeds of Arabidopsis thaliana (2022)
백혈병, 림프종 및 고형 종양의 치료에 사용하기 위한 4-(1H-이미다졸-5-일)-1H-피롤로[2,3-b]피리딘 (2022)
ヌクレアーゼの阻害剤としての置換プロパンアミド (2022)
Substituted propanamides as inhibitors of nucleases (2022)
Substituted aminothiazoles as inhibitors of nucleases (2022)
Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules (2023)
Substituted propanamides as inhibitors of nucleases (2022)
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma (2022)
ヌクレアーゼの阻害剤としての置換アミノチアゾール (2022)
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity (2023)
4-(1H-imidazol-5-yl)-1H-pyrrolo[2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors (2022)
4-(1h- imidazol- 5- yl) -1h-pyrrolo [2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors (2022)
白血病、リンパ腫および固形腫瘍の治療に使用するための４－（１Ｈ－イミダゾール－５－イル）－１Ｈ－ピロロ［２，３－ｂ］ピリジン (2022)
4-(1h- imidazol- 5- yl) -1h-pyrrolo [2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors (2022)
Substituted aminothiazoles as inhibitors of nucleases (2023)
Inhibitory kinázy Haspin (2022)
Substituted aminothiazoles as inhibitors of nucleases (2023)
4-(1H-IMIDAZOL-5-YL)-1H-PYRROLO [2,3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS (2023)
Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells (2024)
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2 (2024)
IDENTIFICATION OF NOVEL CYTOKININS BY MOLECULAR DOCKING (2024)
Unexpectedly Regioselective Diels-Alder Reactions of New Unsymmetrical Benzoquinones: A Convenient Synthetic Entry to Uniquely Substituted Decalins (2024)

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