IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated ...

@article{1084922,
   author = {Hofer, M. and Pospíšil, M. and Dušek, Ladislav and Hoferová, Z. and Komůrková, D.},
   article_location = {Praha},
   article_number = {6},
   keywords = {Mouse; IB-MECA; Adenosine A3 receptor agonist; Lethal gamma-irradiation; Survival},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice},
   url = {http://www.biomed.cas.cz/physiolres/pdf/61/61_649.pdf},
   volume = {61},
   year = {2012}
}

TY  - JOUR
ID  - 1084922
AU  - Hofer, M. - Pospíšil, M. - Dušek, Ladislav - Hoferová, Z. - Komůrková, D.
PY  - 2012
TI  - IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice
JF  - Physiological Research
VL  - 61
IS  - 6
SP  - 649-654
EP  - 649-654
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Mouse
KW  - IB-MECA
KW  - Adenosine A3 receptor agonist
KW  - Lethal gamma-irradiation
KW  - Survival
UR  - http://www.biomed.cas.cz/physiolres/pdf/61/61_649.pdf
N2  - In our previous studies, IB-MECA, an adenosine A3 receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of gamma-rays when the drug was given in a postirradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival was observed in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different. It can be inferred from these results and those of previous studies assessing the effects of IB-MECA after sublethal radiation doses that IB-MECA can probably influence only a substantially preserved hematopoiesis like that remaining after sublethal irradiation. Future studies should be aimed at evaluation of the abilities of IB-MECA to influence post-irradiation survival when administered as a part of combined treatment regimens.
ER  - 

HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ a D. KOMŮRKOVÁ. IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, roč.~61, č.~6, s.~649-654. ISSN~0862-8408. 2012.