RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. Research in Veterinary Sciences. Amsterdam: Elsevier, 2013, Vol. 95, No 1, p. 137-142. ISSN 0034-5288. Available from: https://dx.doi.org/10.1016/j.rvsc.2013.03.011. |
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@article{1107885, author = {Rusek, J. and Klumplerová, Marie and Molinková, Dobromila and Sedlinská, Markéta and Dušek, Ladislav and Mužík, Jan and Putnová, Lenka and Vrtková, Irena and Celer, Vladimír and Hořín, Petr}, article_location = {Amsterdam}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.rvsc.2013.03.011}, keywords = {Antibody responsiveness; Equine herpes virus; Immunity-related molecular markers; Microsatellites; Statistical associations}, language = {eng}, issn = {0034-5288}, journal = {Research in Veterinary Sciences}, title = {Genetics of anti-EHV antibody responses in a horse population}, volume = {Vol. 95}, year = {2013} }
TY - JOUR ID - 1107885 AU - Rusek, J. - Klumplerová, Marie - Molinková, Dobromila - Sedlinská, Markéta - Dušek, Ladislav - Mužík, Jan - Putnová, Lenka - Vrtková, Irena - Celer, Vladimír - Hořín, Petr PY - 2013 TI - Genetics of anti-EHV antibody responses in a horse population JF - Research in Veterinary Sciences VL - Vol. 95 IS - 1 SP - 137-142 EP - 137-142 PB - Elsevier SN - 00345288 KW - Antibody responsiveness KW - Equine herpes virus KW - Immunity-related molecular markers KW - Microsatellites KW - Statistical associations N2 - Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections. ER -
RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. \textit{Research in Veterinary Sciences}. Amsterdam: Elsevier, 2013, Vol. 95, No~1, p.~137-142. ISSN~0034-5288. Available from: https://dx.doi.org/10.1016/j.rvsc.2013.03.011.
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