Speech prosody impairment predicts cognitive decline in Parkinson's disease

@article{1364980,
   author = {Rektorová, Irena and Mekyska, Jiri and Koriťáková, Eva and Košťálová, Milena and Eliášová, Ilona and Mračková, Martina and Beránková, Dagmar and Nečasová, Tereza and Smekal, Zdenek and Mareček, Radek},
   article_location = {OXFORD},
   article_number = {August},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2016.05.018},
   keywords = {Parkinson's disease; Speech prosody; Acoustic analysis; Cognitive; Dementia},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Speech prosody impairment predicts cognitive decline in Parkinson's disease},
   url = {http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278},
   volume = {29},
   year = {2016}
}

TY  - JOUR
ID  - 1364980
AU  - Rektorová, Irena - Mekyska, Jiri - Koriťáková, Eva - Košťálová, Milena - Eliášová, Ilona - Mračková, Martina - Beránková, Dagmar - Nečasová, Tereza - Smekal, Zdenek - Mareček, Radek
PY  - 2016
TI  - Speech prosody impairment predicts cognitive decline in Parkinson's disease
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 29
IS  - August
SP  - 90-95
EP  - 90-95
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Parkinson's disease
KW  - Speech prosody
KW  - Acoustic analysis
KW  - Cognitive
KW  - Dementia
UR  - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
L2  - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
N2  - Background: Impairment of speech prosody is characteristic for Parkinson's disease (PD) and does not respond well to dopaminergic treatment. Objectives: We assessed whether baseline acoustic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by the Addenbrooke's cognitive examination (ACE-R) and/or worsening of cognitive status as assessed by a detailed neuropsychological examination. Methods: Forty-four consecutive non-depressed PD patients underwent clinical and cognitive testing, and acoustic voice analysis at baseline and at the two-year follow-up. Influence of speech and other clinical parameters on worsening of the ACE-R and of the cognitive status was analyzed using linear and logistic regression. Results: The cognitive status (classified as normal cognition, mild cognitive impairment and dementia) deteriorated in 25% of patients during the follow-up. The multivariate linear regression model consisted of the variation in range of the fundamental voice frequency (F0VR) and the REM Sleep Behavioral Disorder Screening Questionnaire (RBDSQ). These parameters explained 37.2% of the variability of the change in ACE-R. The most significant predictors in the univariate logistic regression were the speech index of rhythmicity (SPIR; p = 0.012), disease duration (p = 0.019), and the RBDSQ (p = 0.032). The multivariate regression analysis revealed that SPIR alone led to 73.2% accuracy in predicting a change in cognitive status. Combining SPIR with RBDSQ improved the prediction accuracy of SPIR alone by 73%. Conclusions: Impairment of speech prosody together with symptoms of RBD predicted rapid cognitive decline and worsening of PD cognitive status during a two-year period. (C) 2016 Elsevier Ltd. All rights reserved.
ER  - 

REKTOROVÁ, Irena, Jiri MEKYSKA, Eva KORIŤÁKOVÁ, Milena KOŠŤÁLOVÁ, Ilona ELIÁŠOVÁ, Martina MRAČKOVÁ, Dagmar BERÁNKOVÁ, Tereza NEČASOVÁ, Zdenek SMEKAL a Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2016, roč.~29, August, s.~90-95. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018.