This diploma thesis deals with developing dosage form targeted
to distant areas of GIT. Created dosage form would allow the
transfer of bacteria to the colon which occur naturally there
and thus treat patients with recurrent Clostridium dificille
infection. Using dipping method gelatin and acid-resistant
DRcapsTM capsules were coated with enteric-solvent film and
were subsequently evaluated for their effect on the
biodegradation of the capsules in a simulated gastrointestinal
tract environment. The work assesses, which polymer is the most
suitable for the administration of the microbial content, so
that it gets as far as possible in the GIT without damage.
According to the results, the coated gelatin capsules did not
meet the pharmacopoeial requirements for the enteric dosage
form. DRcapsTM capsules coated with Eudragit® S and cellacefate
were the most resistant to the GIT environment.