The p53/p63/p73 signalling pathway is considered to be one of
the key regulatory pathways of cell proliferation,
differentiation and apoptosis both in normal and transformed
cells. In medulloblastoma, the most common malignant brain
tumor in children, the expression of p73 protein was described
as a factor with as a prognostic factor. value. In this study
we examined the intracellular distribution and pattern of
expression of two N-terminal p73 isoforms, TAp73 and ΔNp73. We
demonstrated that TAp73 isoform is was predominantly localised
in the nucleus, so far whereas ΔNp73 isoform is localised
either in the nucleus or in the nucleus and in the cytoplasm at
the same timesimultaneously.. ΔNp73 co-localised with Golgi
complex in the cytoplasm. The difference in this the
distribution after treatment with all-trans retinoic acid was
observed in ΔNp73, the number of cells with ΔNp73 isoform in
the cytoplasm decreseddecreased after treatment. However, But
it there was were also differences different among particular
experiments, independently on ATRA treatment. Thus, probably,
intracellular localisation of ΔNp73 is probably a complex
process affected by different factors. This study was supported
by grant IGA MZCR NS10218-3/2009.