This thesis focuses on impedance-based cellular assays and
their applications in cell biology and in vitro toxicology. The
theoretical part provides introduction to cell impedimetric
assays and their principles, which is followed by overview of
the most common applications and also brief description of
commercially available systems for cell impedance measurements.
The experimental part focuses on impedimetric evaluation of
normal rat liver epithelial cell line WB-F344 in comparison
with ras oncogene transformed cell line WB-ras. Parameters and
endpoints related to cell adhesion, cohesion and proliferation
were evaluated using commercial system xCELLigence.