During life, somatic cells deal with stress conditions evoked
by unfavorable factors within a cell or in the tissue
microenvironment. The cell responds to stress conditions with
signaling pathways specific for individual organelles. The most
studied molecular pathway is unfolded protein response (UPR)
induced in the endoplasmic reticulum. However, a similar
signaling pathway occurs also in mitochondria. This bachelor
thesis focuses at the canonical UPR in the endoplasmic
reticulum, mitochondrial UPR and interactions of the
endoplasmic reticulum with mitochondria. The molecular basis is
then discussed in the context of selected diseases, where
mitochondrial and ER signaling are involved.