Cholinesterase inhibitors are still among the drugs recognized
in the
therapy of Alzheimer's disease (see Chapter 2.5.1).
Physostigmine,
neostigmine and rivastigmine (Fig. 9 ) are substances that
contain a
carbamate group in their structure. The NMDA receptor inhibitor
memantine, which is sometimes administered in combination with
AChE
inhibitors (see Chapter 2.5.2, fig. ), is based on the
structure of
adamantane. As part of our rigorous work, we focused on these
two
structural elements and decided to prepare a series of eight
aromatic
acids that contain these structural elements in their molecule.
In the next
phase, it was planned to screen the inhibitory activity of
these substances
against AChE and BChE and from these results to select a
suitable
candidate (lead compound) for further structural modification
with the
aim of improving the inhibitory activity. All prepared
substances were
characterized using IR, nuclear and mass spectrometry.