This bachelor thesis aimes at the three theorectical sections summarize the important information about the quality of life of individuals with multiple disabilities. It was characterized cerebral palsy, mental retardtion, epilepsy and allergies. The second part is devoted to the psychosocial issues in relation to individuals with disabilities, their families and the nearby environment. The third chapter is focused to education of children and pupils with multiple disabilities, the special pedagogical diagnostics and therapies, which are a important part of life for people with disabilities. The last chapter deals with the practical research informants was appointed disabilities, analyses their quality of life and the factors that affect their lives.