Cystic fibrosis (CF) is an incurable, autosomal recessive
hereditary genetic disease. Since the end of 2009, CF has been
diagnosed through a screening of newborn babies. This method is
capable of identifying the majority of CF in infancy before the
disease actually develops and manifests itself, thus allowing
for an immediate treatment. In recent years, a targeted and
personalized therapy has also been used as an additional
treatment. This thesis focuses on comparing the quality of life
of patients who were diagnosed with CF through screening
performed at an early age with those who were diagnosed at a
later age, as well as on the impact of modern therapy on the
improve-ment of the monitored parameters. Clinical data were
provided by the Institute of Medical Genetics and Genomics at
the University Hospital Brno (MUDr. Renata Gaillyová, Ph.D.)
and by the Department of Paediatric Infectious Diseases at the
Uni-versity Hospital Brno (Head Physician MUDr. Miriam Malá,
Ph.D.; Head of the De-partment MUDr. Lukáš Homola, Ph.D.)