Protein p53 is very important tumor suppressor. It works as a
transcriptional
factor and it binds to the target sequences of promotors of
several genes, which are important
in terms of cell cycle arrest and apoptosis. It was shown, that
p53 can bind to the various
DNA structure motives. This thesis is concern about tumor
suppressor p53 and its binding
ability to local structures of DNA. Although high percentage of
mutant p53 has impaired its
sequence-specific DNA binding, for these proteins is still
possible to bind with some specifity
to the certain DNA structures. Understanding of these pro
processes can have a big influence
for treatment of cancer and oncologic diseases.