Curriculum Vitae

Životopis

Identifikace osoby

• doc. Mgr. Vítězslav Bryja, Ph.D., *3.7.1977 Vítkov

Pracoviště

• Oddělení fyziologie a imunologie živočichů
  Univerzitní kampus Bohunice, budova A36
  Kamenice 5
  625 00 Brno
  

Funkce na pracovišti

• hlavní manažer projektu, docent

Vzdělání a akademická kvalifikace

• 2014: doc., Masarykova univerzita, Přírodovědecká fakulta
• 2000-2004: Ph.D., Univerzita Karlova, Lékařská fakulta, obor Neurovědy
• 1995-2000: Mgr., Masarykova univerzita, Přírodovědecká fakulta, obor Molekulární biologie a genetika

Přehled zaměstnání

• 12/2014: docent, MU, Ústav experimentální biologie PřF, Oddělení fyziologie a imunologie živočichů
• 3/2007-11/2014: vědecký pracovník, MU, Ústav experimentální biologie PřF, Oddělení fyziologie a imunologie živočichů
• 1/2007: vědecký pracovník, AV ČR, Biofyzikální ústav, Laboratoř cytokinetiky, Brno
• 7/2004 – 6/2007: postdoc, Karolinska Institute, Laboratory of Molecular Neurobiology, Department of Molecular Biochemistry and Biophysics, Stockholm, Švédsko
• 3/2002 – 6/2004: vědecký pracovník, AV ČR, Ústav experimentální medicíny, Praha
• 7/2000 – 6/2004: vědecký pracovník, Univerzita Karlova, Centrum buněčné terapie a tkáňových náhrad, Praha
• 7/2000 – 2/2002: juniorský vědecký pracovník, AV ČR, Ústav živočišné fyziologie a genetiky, Liběchov

Pedagogická činnost

• Bi1110 - Fyziologie živočišné buňky
• Bi9903 - Vývojová fyziologie živočichů I
• Bi9906 - Vývojová fyziologie živočichů II
• Bi9904 - Časopisový klub OFIŽ I
• Bi9905 - Časopisový klub OFIŽ II
• Bi5611c - Speciální metody fyziologie živočichů
• DSCC060 - Life science seminar
• MCC060 - Life science seminar
• S5030 - MU Life Sciences Seminar
• XD010 - MU Life Sciences Seminar
• Bi5599 Metody aplikované biochemie a buněčné biologie
• Bi9903 Vývojová biologie živočichů
• Bi1110 Fyziologie živočišné buňky
• Bi7070 Fyziologie buněčných systémů
• vedení bakalářských, diplomových a doktorských prací

Vědeckovýzkumná činnost

• Mým hlavním vědeckým zájmem je porozumět přenosu Wnt signálu in vitro a in vivo a jak jednotlivé komponety Wnt signální dráhy přispívají k patogenezi lidských chorob.

Akademické stáže

• 7/2004 – 6/2007: postdoc, Karolinska Institute, Laboratory of Molecular Neurobiology, Department of Molecular Biochemistry and Biophysics, Stockholm, Švédsko

Univerzitní aktivity

• Organizace MU Life Sciences Seminar (https://seminarseries.muni.cz/life-sciences/).
• Organizace mezinárodní konference Wnt Meeting 2016, Brno (http://wnt2016.muni.cz/).
• Organizace konference Wnt Meeting 2010 ve Stockholmu (http://wnt2010.ki.se/index.php)

Mimouniverzitní aktivity

• Zvané přednášky:
• Konference: Conference of Johann Gregor Mendel Society of Genetics, Bratislava (2008); Wnt2010, Karolinska Institute, Stockholm (2010); EMBO Young Investigator Programme Meetings (2008-2012; 7 přednášek); Understanding Cancer Stem Cells, La Coruna, Spain (2011); Neuronus, IBRO Forum, Krakow (2012)
• Semináře: Cedars Sinai Medical Center (Los Angeles, 2007); Max Planck Institute of Molecular Genetics (Berlin, 2008); German WNT Forschungsgruppe (Karlsruhe, 2010); University of Göttingen (Göttingen, 2012), Insitute Curie (Paris, 2013), Centre for Cancer Research (Marseille, 2013)

Ocenění

• EMBO Installation Grant (European Molecular Biology Organization, 2007)
• Cena ministryně školství, mládeže a tělovýchovy za mimořádné výsledky výzkumu, experimentálního vývoje a inovací (2012)
• Cena předsedy Grantové agentury ČR (GA ČR, 2014)
• Cena Neuron Impuls 2016 (Neuron - fond na podporu vědy, 2016)

Vybrané publikace

• PLEŠINGEROVÁ, Hana, Pavlína JANOVSKÁ, Ashish Kumar MISHRA, Lucie SMYČKOVÁ, Lucie POPPOVÁ, A. LIBRA, Karla PLEVOVÁ, Petra OVESNÁ, Lenka RADOVÁ, Michael DOUBEK, Šárka PAVLOVÁ, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia (Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia.). Haematologica/the hematology journal. Fondazione Ferrata Storti, 2018, vol. 103, No 2, p. 313-324. ISSN 0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2017.178699. URL info
• JANOVSKÁ, Pavlína, Jan VERNER, Jiří KOHOUTEK, Lenka BRYJOVÁ, Michaela GREGOROVÁ, Marta DZIMKOVÁ, Hana ŠKABRAHOVÁ, Tomasz Witold RADASZKIEWICZ, Petra OVESNÁ, Olga VONDÁLOVÁ BLANÁŘOVÁ, Tereza NĚMCOVÁ, Zuzana HOFEROVA, Kateřina VAŠÍČKOVÁ, Lucie NESVADBOVÁ, Alexander EGLE, Šárka PAVLOVÁ, Lucie POPPOVÁ, Karla PLEVOVÁ, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia. Blood. Washington DC, USA: American Society of Hematology, 2018, vol. 131, No 11, p. 1206-1218. ISSN 0006-4971. Available from: https://dx.doi.org/10.1182/blood-2017-05-786947. URL info
• LEE, Y., N.H. KIM, E.S. CHO, J.H. YANG, Y.H. CHA, H.E. KANG, J.S. YUN, S.B. CHO, S.H. LEE, Petra PACLÍKOVÁ, Tomasz Witold RADASZKIEWICZ, Vítězslav BRYJA, C.G. KANG, Y.S. YUK, S.Y. CHA, S.Y. KIM, H.S. KIM and J.I. YOOK. Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Nature Communications. London: Nature Publishing Group, 2018, vol. 9, No 1, p. 1-16. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-018-04757-w. URL info
• MENTINK, R.A., L. RELLA, Tomasz Witold RADASZKIEWICZ, Tomáš GYBEĽ, M.C. BETIST, Vítězslav BRYJA and H.C. KORSWAGEN. The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/beta-catenin signaling through a Dvl dependent mechanism. PLoS Genetics. San Francisco: Public Library of Science, 2018, vol. 14, No 12, p. 1-22. ISSN 1553-7404. Available from: https://dx.doi.org/10.1371/journal.pgen.1007840. URL info
• LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING and Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. London: Nature Publishing Group, 2017, vol. 31, No 2, p. 361-372. ISSN 0887-6924. Available from: https://dx.doi.org/10.1038/leu.2016.232. URL info
• BERNATÍK, Ondřej, Tomasz Witold RADASZKIEWICZ, Martin BĚHAL, Zankruti DAVE, Florian WITTE, Annika MAHL, Nicole ČERNOHORSKÁ, Pavel KREJČÍ, Sigmar STRICKER and Vítězslav BRYJA. A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation. Frontiers in Cell and Developmental Biology. Lausanne: Frontiers Media S.A., 2017, vol. 5, MAY, p. 1-9. ISSN 2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2017.00047. URL info
• PLEŠINGEROVÁ, Hana, Zuzana LIBROVA, Karla PLEVOVÁ, Antonín LIBRA, Boris TICHÝ, Hana SKUHROVÁ FRANCOVÁ, Filip VRBACKY, Lukáš SMOLEJ, Jiří MAYER, Vítězslav BRYJA, Michael DOUBEK and Šárka POSPÍŠILOVÁ. COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status. LEUKEMIA & LYMPHOMA. Oxon: TAYLOR & FRANCIS LTD, 2017, vol. 58, No 1, p. 70-79. ISSN 1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2016.1180690. URL info
• LINKE, F., S. ZAUNIG, M.M. NIETERT, Bonin F. VON, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, T. BEISSBARTH, F. ALVES, W. KLAPPER, Vítězslav BRYJA, T. PUKROP, L. TRUMPER, J. WILTING and D. KUBE. WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene. London: Nature Publishing Group, 2017, vol. 36, No 1, p. 13-23. ISSN 0950-9232. Available from: https://dx.doi.org/10.1038/onc.2016.183. info
• PACLÍKOVÁ, Petra, Ondřej BERNATÍK, Tomasz Witold RADASZKIEWICZ and Vítězslav BRYJA. The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/beta-Catenin Signaling in Mammalian Cells. Molecular and cellular biology. WASHINGTON: AMER SOC MICROBIOLOGY, 2017, vol. 37, No 18, p. nestránkováno, 16 pp. ISSN 0270-7306. Available from: https://dx.doi.org/10.1128/MCB.00145-17. info
• SALAŠOVÁ, Alena, C. YOKOTA, David POTĚŠIL, Zbyněk ZDRÁHAL, Vítězslav BRYJA and E. ARENAS. A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway. MOLECULAR NEURODEGENERATION. LONDON: BIOMED CENTRAL LTD, 2017, vol. 12, No 54, p. 1-19. ISSN 1750-1326. Available from: https://dx.doi.org/10.1186/s13024-017-0193-9. info
• BRYJA, Vítězslav, Igor ČERVENKA and Lukáš ČAJÁNEK. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? Critical Reviews in Biochemistry and Molecular Biology. Abingdon: TAYLOR & FRANCIS LTD, 2017, vol. 52, No 6, p. 614-637. ISSN 1040-9238. Available from: https://dx.doi.org/10.1080/10409238.2017.1350135. URL info
• STRAKOVÁ, Kateřina, Pierre MATRICON, Chika YOKOTA, Elisa ARTHOFER, Ondřej BERNATÍK, David RODRIGUEZ, Ernesto ARENAS CASES, Jens CARLSSON, Vítězslav BRYJA and Gunnar SCHULTE. The tyrosine Y250 2.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled. Cellular Signalling. New York: ELSEVIER SCIENCE, 2017, vol. 38, October, p. 85-96. ISSN 0898-6568. Available from: https://dx.doi.org/10.1016/j.cellsig.2017.06.018. URL info
• JANOVSKÁ, Pavlína, Jan VERNER, Jiří KOHOUTEK, Lenka BRYJOVÁ, Marta DZIMKOVÁ, H. SKABRAHOVA, Tomasz Witold RADASZKIEWICZ, Tereza NĚMCOVÁ, Zuzana HOFEROVÁ, Kateřina VAŠÍČKOVÁ, Lucie SMYCKOVA, Michaela GREGOROVÁ, A. EGLE, Šárka PAVLOVÁ, Lucie POPPOVÁ, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. Casein kinase 1 delta/epsilon inhibition blocks CLL chemotaxis and delays leukemia onset in the Eµ-TCL1 mouse model of chronic lymphocytic leukemia. In XVII International Workshop on Chronic Lymphocytic Leukemia. 2017. info
• JANOVSKÁ, Pavlína and Vítězslav BRYJA. WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas. BRITISH JOURNAL OF PHARMACOLOGY. Hoboken: WILEY, 2017, vol. 174, No 24, p. 4701-4715. ISSN 0007-1188. Available from: https://dx.doi.org/10.1111/bph.13949. info
• BRYJA, Vítězslav, Pavlína JANOVSKÁ, Kamil PARUCH, Václav NĚMEC and Michaela GREGOROVÁ. Kompletní analýza vlastností nových inhibitorů kasein kinázy 1 pro léčbu chronické lymfocytární leukémie (Complete analysis of novel inhibitors of casein kinase 1 for the treatment of chronic lymphocytic leukemia). 2017. info
• JANOVSKÁ, Pavlína, Lucie POPPOVÁ, Karla PLEVOVÁ, Hana PLEŠINGEROVÁ, Martin BĚHAL, Markéta KAUCKÁ, Petra OVESNÁ, Michaela HLOŽKOVÁ, Marek BORSKÝ, Olga STEHLÍKOVÁ, Yvona BRYCHTOVÁ, Michael DOUBEK, Michaela MÁCHALOVÁ, Sivasubramanian BASKAR, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia. Clinical cancer research. USA, 2016, vol. 22, No 2, p. 459-469. ISSN 1078-0432. Available from: https://dx.doi.org/10.1158/1078-0432.CCR-15-0154. URL info
• ŠTĚPKA, Karel, Martin MAŠKA, Jakub Jozef PÁLENIK, Vendula POSPÍCHALOVÁ, Anna KOTRBOVÁ, Ladislav ILKOVICS, Dobromila KLEMOVÁ, Aleš HAMPL, Vítězslav BRYJA and Pavel MATULA. Automatic Detection and Segmentation of Exosomes in Transmission Electron Microscopy. In Gang Hua, Hervé Jégou. Computer Vision -- ECCV 2016 Workshops: Amsterdam, The Netherlands, October 8-10 and 15-16, 2016, Proceedings, Part I. Cham, Switzerland: Springer International Publishing, 2016, p. 318-325. ISBN 978-3-319-46603-3. Available from: https://dx.doi.org/10.1007/978-3-319-46604-0_23. http://dx.doi.org/10.1007/978-3-319-46604-0_23 info
• BRYJA, Vítězslav, Markéta KAUCKÁ, Karla PLEVOVÁ, Šárka PAVLOVÁ, Šárka POSPÍŠILOVÁ and Alois KOZUBÍK. CASEIN KINASE 1 INHIBITORS FOR THE TREATMENT OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA. 2016. URL info
• POPPOVÁ, Lucie, Pavlína JANOVSKÁ, Karla PLEVOVÁ, Lenka RADOVÁ, Hana PLEŠINGEROVÁ, Marek BORSKÝ, Jana KOTAŠKOVÁ, Barbara KANTOROVÁ, Michaela HLOŽKOVÁ, Jana FIGULOVÁ, Yvona BRYCHTOVÁ, Michael DOUBEK, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Decreased expression of WNT3, a canonical Wnt pathway ligand is frequent in chronic lymphocytic leukemia progression and identifies patients with short treatment-free survival in mutated IGHV. In Haematologica (2016); 101(s1): 423-424. (21st Congress of the EHA). 2016. info
• ČERVENKA, Igor, Jana VALNOHOVÁ, Ondřej BERNATÍK, Jakub HARNOŠ, Matěj RÁDSETOULAL, Kateřina ŠEDOVÁ, Kateřina HANÁKOVÁ, David POTĚŠIL, Miroslava SEDLÁČKOVÁ, Alena SALAŠOVÁ, Zachary STEINHART, Stephane ANGERS, Gunnar SCHULTE, Aleš HAMPL, Zbyněk ZDRÁHAL and Vítězslav BRYJA. Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins. Proceedings of the National Academy of Sciences of the United States of America. Washington: National Academy of Sciences, 2016, vol. 113, No 33, p. 9304-9309. ISSN 0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1608783113. info
• POPPOVÁ, Lucie, Pavlína JANOVSKÁ, Karla PLEVOVÁ, Lenka RADOVÁ, Hana PLEŠINGEROVÁ, Marek BORSKÝ, Jana KOTAŠKOVÁ, Barbara KANTOROVÁ, Michaela HLOŽKOVÁ, Jana FIGULOVÁ, Yvona BRYCHTOVÁ, Michaela MÁCHALOVÁ, Milan URÍK, Michael DOUBEK, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV. British journal of haematology. Wiley-Blackwell, 2016, vol. 175, No 5, p. 851-859. ISSN 0007-1048. Available from: https://dx.doi.org/10.1111/bjh.14312. info
• BRYJA, Vítězslav, Markéta KAUCKÁ, Karla PLEVOVÁ, Šárka PAVLOVÁ, Šárka POSPÍŠILOVÁ and Alois KOZUBÍK. CASEIN KINASE 1 INHIBITORS FOR THE TREATMENT OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA. 2016. URL info
• KAUCKÁ, Markéta, Julian PETERSEN, Pavlína JANOVSKÁ, Tomasz Witold RADASZKIEWICZ, Lucie SMYČKOVÁ, Avais M DAULAT, Jean-Paul BORG, Gunnar SCHULTE and Vítězslav BRYJA. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway. Journal of Cell Communication and Signaling. 2015, vol. 13, January, p. "nestrankovano", 14 pp. ISSN 1478-811X. Available from: https://dx.doi.org/10.1186/s12964-014-0079-1. info
• POSPÍCHALOVÁ, Vendula, Jan SVOBODA, Zankruti DAVE, Anna KOTRBOVÁ, Karol KAISER, Dobromila KLEMOVÁ, Ladislav ILKOVICS, Aleš HAMPL, Igor CRHA, Eva JANDÁKOVÁ, Luboš MINÁŘ, Vít WEINBERGER and Vítězslav BRYJA. Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer. Journal of Extracellular Vesicles. Järfälla: Co-Action Publishing, 2015, vol. 4, No 25530, p. 1-15. ISSN 2001-3078. Available from: https://dx.doi.org/10.3402/jev.v4.25530. URL info
• BUCHTOVÁ, marcela, Veronika ORALOVÁ, Anie AKLIAN, Jan MAŠEK, Iva VESELA, Zhufeng OUYANG, Tereza OBADALOVÁ, Žaneta KONEČNÁ, Tereza SPOUSTOVÁ, Tereza POSPÍŠILOVÁ, Petr MATULA, Miroslav VAŘECHA, Lukáš BÁLEK, Iva GUDERNOVÁ, Iva JELÍNKOVÁ, Ivan DURAN, Iveta ČERVENKOVÁ, Shunichi MURAKAMI, Alois KOZUBÍK, Petr DVOŘÁK, Vítězslav BRYJA and Pavel KREJČÍ. Fibroblast growth factor and canonical WNT/beta-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage. Biochimica et Biophysica Acta - Molecular Basis of Disease. Amsterdam: ELSEVIER SCIENCE BV, 2015, vol. 1852, No 5, p. 839-850. ISSN 0925-4439. Available from: https://dx.doi.org/10.1016/j.bbadis.2014.12.020. info
• BRYJA, Vítězslav, Pavel KREJČÍ, Markéta KAUCKÁ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Alois KOZUBÍK, Jana KOTAŠKOVÁ and Karla PLEVOVÁ. Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method. 2015. info
• KILLANDER, Michaela BC, Julian PETERSEN, Kjetil Wessel ANDRESSEN, Sri Ranjani GANJI, Finn Olav LEVY, Jens SCHUSTER, Niklas DAHL, Vítězslav BRYJA and Gunnar SCHULTE. Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. FASEB JOURNAL. 2014, vol. 28, No 5, p. 2293-2305. ISSN 0892-6638. Available from: https://dx.doi.org/10.1096/fj.13-246363. info
• BERNATÍK, Ondřej, Kateřina ŠEDOVÁ, Carolin SCHILLE, Sri Ranjani GANJI, Igor ČERVENKA, Lukáš TRANTÍREK, Alexandra SCHAMBONY, Zbyněk ZDRÁHAL and Vítězslav BRYJA. Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2014, vol. 289, No 34, p. 23520-23533. ISSN 0021-9258. Available from: https://dx.doi.org/10.1074/jbc.M114.590638. URL info
• KAUCKÁ, Markéta, Karla PLEVOVÁ, Šárka PAVLOVÁ, Pavlína JANOVSKÁ, Archana SHAIK, Jan VERNER, Jiřina PROCHÁZKOVÁ, Pavel KREJČÍ, Jana KOTAŠKOVÁ, Petra OVESNÁ, Boris TICHÝ, Yvona BRYCHTOVÁ, Michael DOUBEK, Alois KOZUBÍK, Jiří MAYER, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration. Cancer Research. USA: American Association for Cancer Research, 2013, vol. 73, No 5, p. 1491-1501. ISSN 0008-5472. Available from: https://dx.doi.org/10.1158/0008-5472.CAN-12-1752. URL info
• CHAKI, Moumita, Rannar AIRIK, Amiya K. GHOSH, Rachel H. GILES, Rui CHEN, Gisela G. SLAATS, Hui WANG, Toby W. HURD, Weibin ZHOU, Andrew CLUCKEY, Heon-Yung GEE, Gokul RAMASWAMI, Chen-Jei HONG, Bruce A. HAMILTON,, Igor ČERVENKA, Sri Ranjani GANJI, Vítězslav BRYJA, Heleen H. ARTS, Jeroen VAN REEUWIJK, Machteld M. OUD, Stef J.F. LETTEBOER, Ronald ROEPMAN, Hervé HUSSON, Oxana IBRAGHIMOV-BESKROVNAYA, Takayuky YSUNAGA, Gerd WALZ, Lorraine ELEY, Bernhard SCHERMER, John A. SYAER, Max C. LIEBAU, Thomas BENZING, Stephanie LE CORRE, Iain DRUMMOND, Sabine JANSSEN, Susan J. ALLEN, Sivakumar NATARAJAN, John F. O TOOLE, Massimo ATTANASIO, Sophie SAUNIER, Corinne ANTIGNAC, Robert K. KOENEKOOP, Huanan REN, Irma LOPEZ, Ahmet NAYIR, Corinne STOETZEL, Helene DOLLFUS, Rustin MASSOUDI, Joseph G. GLEESON, Sharon P. ANDREOLI, Dan G. DOHERTY, Anna LINDSTRAD, Christelle GOLZIO, Nicholas KATSANIS, Lars PAPE, Emad B. ABBOUD, Ali A. AL-RAJHI, Richard A. LEWIS, Heymut OMRAN, Eva LEE, Shaohui WANG, JoAnn M. SEKIGUCHI, Rudel SAUNDERS, Colin A. JOHNSON, Elizabeth GARNER, Katja VANSELOW, Jens S. ANDERSEN, Joseph SHLOMAI, Gudrun NURNBERG, Peter NURNBERG, Shawn LEVY, Agata SMOGORZEWSKA, Edgar A. OTTO and Friedhelm HILDEBRANDT. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. United States of America: Cell Press, Cambridge, MA, USA, 2012, vol. 150, No 3, p. 533-548. ISSN 0092-8674. Available from: https://dx.doi.org/10.1016/j.cell.2012.06.028. info
• ANDERSSON, Emma, Lenka BRYJOVÁ, Kristin BIRIS, Terry YAMAGUCHI, Ernest ARENAS and Vítězslav BRYJA. Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development. Developmental dynamics. United States: Wiley-Liss, 2010, vol. 2010, No 239, 9 pp. ISSN 1058-8388. info
• LINDQVIST, Maria, Zachi HORN, Vítězslav BRYJA, Gunnar SCHULTE, Panagiotis PAPACHRISTOU, Rieko AJIMA, Cecilia DYBERG, Ernest ARENAS, Terry P YAMAGUCHI, Hugo LAGERCRANTZ and Thomas RINGSTEDT. Vang-like protein 2 and Rac 1 interact to regulate adherens junctions. JOURNAL OF CELL SCIENCE. 2010, vol. 2010, No 123, p. 472-483. ISSN 0021-9533. info
• SCHULTE, Gunnar, Alexandra SCHAMBONY and Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?). British Journal of Pharmacology. 2010, vol. 159, No 5, p. 1051-8, 8 pp. ISSN 1476-5381. info
• KREJČÍ, Pavel, Jiřina PROCHÁZKOVÁ, Vítězslav BRYJA, Petra JELÍNKOVÁ, Kateřina PEJCHALOVÁ, Alois KOZUBÍK, Leslie Michels TOMPSON and William R. WILCOX. Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cellular Signalling. 2009, vol. 21, No 1, p. 151-160. ISSN 0898-6568. Available from: https://dx.doi.org/10.1016/j.cellsig.2008.10.006. info
• ANDERSSON, Therese, Erik SÖDERSTEN, Joshua DUCKWORTH K., Anna CASCANTE, Nicolas FRITZ, Paola SACCHETTI, Igor ČERVENKA, Vítězslav BRYJA and Ola HERMANSON. CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells. Journal of Biological Chemistry. 2009, vol. 284, No 6, 10 pp. ISSN 0021-9258. info
• CHLEBOVÁ, Katarína, Vítězslav BRYJA, Petr DVOŘÁK, Alois KOZUBÍK, W.R. WILCOX and Pavel KREJČÍ. High molecular weight FGF2: the biology of a nuclear growth factor. Cellular and molecular life sciences : CMLS. Switzerland, 2009, vol. 66, No 2, p. 225-235. ISSN 1420-682X. Available from: https://dx.doi.org/10.1007/s00018-008-8440-4. info
• YANG, Dong-Hwa, Ju-Young YOON, Soung-Hoon LEE, Vítězslav BRYJA, Emma R. ANDERSSON, Ernest ARENAS, Young-Guen KWON and Kang-Yell CHOI. Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa. Circulation Research. 2009, vol. 104, No 3, p. 372-379. ISSN 1524-4571. info
• ČAJÁNEK, Lukáš, Diogo RIBEIRO, Isabel LISTE, Clare PARISH, Vítězslav BRYJA and Ernest ARENAS. Wnt/beta-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells. Stem Cells. 2009, vol. 27, No 12, p. 2917-2927. ISSN 1549-4918. info
• KREJČÍ, Pavel, Jiřina PROCHÁZKOVÁ, Vítězslav BRYJA, Alois KOZUBÍK and William WILCOX. Molecular pathology of the fibroblast growth factor family. Human Mutation. 2009, vol. 30, No 9, p. 1245-55, 11 pp. ISSN 1059-7794. Available from: https://dx.doi.org/10.1002/humu.21067. URL info
• KUNKE, David, Vítězslav BRYJA, Line MYGLAND, Ernest ARENAS and Stefan KRAUSS. Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs. Biochemical and Biophysical Research Communications. 2009, vol. 386, No 4, 6 pp. ISSN 0006-291X. info
• BRYJA, Vítězslav, Alexandra SCHAMBONY, Lukáš ČAJÁNEK, Isabel DOMINGUEZ, Ernest ARENAS and Gunnar SCHULTE. Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO REPORTS. 2008, vol. 9, No 12, p. 1244-1250. ISSN 1469-221X. info
• ANDÄNG, Michael, Jens HJERLING-LEFFLER, Annalena MOLINER, T. Kalle LUNDGREN, Goncalo CASTELO-BRANCO, Evanthia NANOU, Ester POZAS, Vítězslav BRYJA, Sophie HALLIEZ, Hiroshi NISHIMARU, Johannes WILBERTZ, Ernest ARENAS, Martin KOLTZENBURG, Patrick CHARNAY, Abdeljabbar EL MANIRA, Carlos F. IBAÑEZ and Patrik ERNFORS. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature. 2008, vol. 451, No 7177, p. 460-464. ISSN 0028-0836. info
• ANDERSSON, Emma R., Nilima PRAKASH, Lukáš ČAJÁNEK, Eleonora MININA, Vítězslav BRYJA, Lenka BRYJOVÁ, Terry P. YAMAGUCHI, Anita C. HALL, Wolfgang WURST and Ernest ARENAS. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vitro. PloS ONE. 2008, vol. 3, No 10, 14 pp. ISSN 1932-6203. info
• BRYJA, Vítězslav, Jiří PACHERNÍK, Jan VONDRÁČEK, Karel SOUČEK, Lukáš ČAJÁNEK, Viktor HORVÁTH, Zuzana HOLUBCOVÁ, Petr DVOŘÁK and Aleš HAMPL. Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin. Cell Proliferation. 2008, vol. 41, No 6, p. 875-93, 19 pp. ISSN 0960-7722. info
• KREJČÍ, Pavel, Lisa SALAZAR, Tamara A. KASHIWADA, Katarína CHLEBOVÁ, Alena SALAŠOVÁ, Leslie Michels THOMPSON, Vítězslav BRYJA, Alois KOZUBÍK and William R. WILCOX. Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. PLoS ONE. 2008, vol. 3, No 12, p. 72-81, 8 pp. ISSN 1932-6203. info
• BRYJA, Vítězslav, Emma R. ANDERSSON, Alexandra SCHAMBONY, Milan ESNER, Lenka BRYJOVÁ, Kristin K. BIRIS, Anita C. HALL, Bianca KRAFT, Lukáš ČAJÁNEK, Terry P. YAMAGUCHI, Margaret BUCKINGHAM and Ernest ARENAS. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. : Molecular Biology of the Cell. 2008, vol. 20, No 3, 13 pp. ISSN 1059-1524. info
• JUNG, Gyung-Ah, Ju-Yong YOON, Byoung-San MOON, Dong-Hwa YANG, Hyun-Yi KIM, Sang-Hun LEE, Vítězslav BRYJA, Ernast ARENAS and Kang-Yell CHOI. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21 Cip/WAF 1 pathway. BMC Cell Biology. 2008, vol. 9, No 66. ISSN 1471-2121. info
• VAŇHARA, Petr, Vítězslav BRYJA, Viktor HORVÁTH, Alois KOZUBÍK, Aleš HAMPL and Jan ŠMARDA. c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2. Biochemical and Biophysical Research Communications. San Diego (USA): Academic Press, 2007, vol. 353, No 1, p. 92-97. ISSN 0006-291X. info
• BRYJA, Vítězslav, G. SCHULTE and E. ARENAS. Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cellular Signalling. 2007, vol. 19, p. 610-616. ISSN 0898-6568. info
• BRYJA, Vítězslav, G. SCHULTE, N. RAWAL, A. GRAHN and E. ARENAS. Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. Journal of Cell Science. Cambridge: Company of Biologists Ltd., 2007, vol. 120, No 4, p. 586-595. ISSN 0021-9533. info
• BRYJA, Vítězslav, Lukáš ČAJÁNEK, A. GRAHN and G. SCHULTE. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. Acta Physiologica. Oxford: Blackwell Publishing, 2007, vol. 190, No 1, p. 53-59. ISSN 1748-1708. info
• BRYJA, Vítězslav, D. GRADL, A. SCHAMBONY, E. ARENAS and G. SCHULTE. beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proceedings of the National Academy of Sciences of the U.S.A. 2007, vol. 104, No 16, p. 6690-6695. ISSN 1091-6490. info
• SCHULTE, G. and Vítězslav BRYJA. The Frizzled family of unconventional GPCRs. Trends in Pharmacological Sciences. 2007, vol. 28, No 10, p. 518-525. ISSN 0165-6147. info
• CASTELO-BRANCO, G., K.M. SOUSA, Vítězslav BRYJA, L. PINTO, J. WAGNER and E. ARENAS. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Molecular and Cellular Neuroscience. 2006, vol. 31, p. 251-62. ISSN 1044-7431. info
• BRYJA, Vítězslav, S. BONILLA, Lukáš ČAJÁNEK, C.L. PARISH, C.M. SCHWARTZ, Y. LUO, M.S. RAO and E. ARENAS. An efficient method for the derivation of mouse embryonic stem cells. Stem Cells. 2006, vol. 24, p. 844-849. ISSN 1066-5099. info
• BRYJA, Vítězslav, S. BONILLA and E. ARENAS. Derivation of mouse embryonic stem cells. Nature Protocols. Nature Publishing Group, 2006, vol. 1, p. 2082-2087. ISSN 1745-2473. info
• PACHERNÍK, J., V. BRYJA, M. EŠNER, P. DVOŘÁK and Aleš HAMPL. Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor. Physiol. Res. 2005, vol. 54, No 2, p. 257-262. ISSN 0862-8408. info
• PACHERNÍK, J., V. BRYJA, M. EŠNER, L. KUBALA, Petr DVOŘÁK and Aleš HAMPL. Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid - inhibitory effect of serum. Physiol. Res. 2005, vol. 54, No 1, p. 115-122. ISSN 0862-8408. info
• BRYJA, Vítězslav, Lukáš ČAJÁNEK, Jiří PACHERNÍK, A.C. HALL, Viktor HORVÁTH, Petr DVOŘÁK and Aleš HAMPL. Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. Stem Cells. 2005, vol. 23, No 7, p. 965-974. ISSN 1066-5099. info
• VONDRÁČEK, J., M. MACHALA, V. BRYJA, K. CHRAMOSTOVÁ, P. KRČMÁR, C. DIETRICH, Aleš HAMPL and Alois KOZUBÍK. Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells. Toxicological sciences. 2005, vol. 83, No 1, p. 53-63. ISSN 1096-6080. info
• SCHULTE, G., Vítězslav BRYJA, N. RAWAL, G. CASTELO-BRANCO, K.M. SOUSA and E. ARENAS. Purified HA-Wnt5a increases differentiation of dopaminergic precursor cells. Journal of Neurochemistry. 2005, vol. 92, p. 1550-1553. ISSN 0022-3042. info
• BRYJA, V., J. PACHERNÍK, L. FALDÍKOVÁ, P. KREJČÍ, R. POGUE, I. NEVŘIVÁ, P. DVOŘÁK and Aleš HAMPL. The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo. Biochimica et Biophysica Acta. 2004, vol. 1691, 2-3, p. 105-116. ISSN 0006-3002. info
• BRYJA, V., J. PACHERNÍK, K. SOUČEK, V. HORVATH, P. DVOŘÁK and Aleš HAMPL. Increased apoptosis in differentiating p27-deficient mouse embryonic stem cells. Cellular and molecular life sciences. 2004, vol. 61, No 11, p. 1384-1400. ISSN 1420-682X. info
• JENDELOVÁ, P., V. HERYNEK, L. URDZÍKOVÁ, K. GLOGAROVÁ, J. KROUPOVÁ, B. ANDERSSON, V. BRYJA, M. BURIAN, M. HÁJEK and E. SYKOVÁ. MR tracking of transplanted bone marrow and embryonic stem cells labeled by iron-oxide nanoparticles in rat brain and spinal cord. Journal of Neuroscience Research. 2004, vol. 76, p. 232-243. ISSN 0360-4012. info
• KREJČÍ, Pavel, Vítězslav BRYJA, Jiří PACHERNÍK, Aleš HAMPL, R. POGUE and W.R. WILCOX. FGFs inhibit proliferation and alter the cartilage-like phenotype of RCS cells. Experimental Cell Research. Elsevier, 2004, vol. 297, p. 152-164. ISSN 0014-4827. info
• BRYJA, V., J. PACHERNÍK, L. KUBALA, Aleš HAMPL and P. DVOŘÁK. The reverse tetracycline-controlled transactivator rtTA2s-S2 is toxic in mouse embryonic stem cells. Reproduction, nutrition, development. 2003, vol. 43, No 6, p. 477-486. ISSN 0926-5287. info
• ANGER, M., V. BRYJA, L. JIRMANOVÁ, Aleš HAMPL, J. MOTLÍK, P. DVOŘÁK and M. KUBELKA. The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. Biochemical and biophysical research communications. 2003, vol. 302, No 4, p. 825-830. ISSN 0006-291X. info
• BRYJA, Vítězslav, Jiří PACHERNÍK, Lukáš KUBALA, Aleš HAMPL and Petr DVOŘÁK. The Reverse Tetracycline-Controlled Transactivator Rtta2(S)-S2 Is Toxic in Mouse Embryonic Stem Cells. Reproduction Nutrition Development. 2003, vol. 43, No 6, p. 477-486, 9 pp. ISSN 0926-5287. info
• PRECLÍKOVÁ, H., Vítězslav BRYJA, Jiří PACHERNÍK, Pavel KREJČÍ, Petr DVOŘÁK and Aleš HAMPL. Early cycling-independent changes to p27, cyclin D2, and cyclin D3 in differentiating mouse embryonal carcinoma cells. Cell Growth and Differentiation. 2002, vol. 13, p. 421-430. ISSN 1044-9523. info
• PACHERNÍK, Jiří, M. EŠNER, Vítězslav BRYJA, Petr DVOŘÁK and Aleš HAMPL. Neural differentiation of mouse embryonic stem cells grown in monolayer. Reproduction Nutrition Development. 2002, vol. 42, p. 317-326. ISSN 1297-9708. info
• PACHERNÍK, Jiří, R. JANÍK, Jiřina HOFMANOVÁ, Vítězslav BRYJA and Alois KOZUBÍK. Conditions for gene transfection into the HL-60 human leukaemia cell line by electroporation. Folia Biologica. 2002, vol. 48, p. 157-159. ISSN 0015-5500. info

2019/03/19