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Curriculum Vitae

Osobní údaje
  • Assoc. Prof. Lumir Krejci, Ph.D
    Born 30.3.1972
    married, 3 children
Workplace
  • Department of Biology, Faculty of Medicine, Masaryk University in Brno
    Kamenice 5
    625 00 Brno
    Tel: 549 49 3767
    Email: lkrejci@chemi.muni.cz


    National Centre for Biomolecular Research
    Faculty of Science, Masaryk University
    Kamenice 5/A4
    Brno 625 00
    Tel: (420) 549493767
    Email: lkrejci@chemi.muni.cz


    webove stranky skupiny LORD
Employment - Position
  • Associate Professor
Education and Academic Qualifications
  • 1993: B.Sc. in Biochemistry, Faculty of Science, Masaryk University
  • 1995: M.Sc. in Biochemistry, Faculty of Science, Masaryk University MU
  • 2000: Ph.D. in Molecular and Cell Biology, Faculty of Science, Masaryk University
  • 2013: Assoc.Prof. in Medical Biology, Faculty of Medicine, Masaryk University

Employment
  • 1995 - 1997: Graduate Fellow, Department of Molecular Biology, Aarhus University, Denmark
  • 1997 - 2000: Graduate Fellow, Danish Institute of Agricultural Science, Denmark
  • 2000 - 2001: Research Scientist, Masaryk University, Brno, Czech Republic
  • 2001 - 2003: Postdoctoral Fellow, Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, USA
  • 2003 - 2004: Postdoctoral Associate, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA
  • 2004 - 2005: Associate Research Scientist, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA
  • 2005 - present: research associate, National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno
  • 2009 - 2013: research associate, Department of Biology, Faculty of Medicine, Masaryk University, Brno
  • 2013 - present: Associate Professor, Department of Biology, Faculty of Medicine, Masaryk University, Brno
  • 2011 - present: Senior Researcher, International Clinical Research Center, St. Anne's University Hospital, Brno
  • 2015 - 2016: Vice Chair for Basic Research, International Clinical Research Center, St. Anne's University Hospital, Brno
Teaching Activities
  • Pregradual and doctoral courses
    Biology I
    Biology II
    Molecular Biology and Genetics
    Masaryk University Life Sciences Seminar
    Protein Preparation and Characterization III - practice
    Cell biology and genetics - seminar

    Invited lectures
  • EMBO/HHMI Central European Scientists Meeting, Dubrovnik, Croatia, June 15 – 17, 2006
  • HHMI Meeting of International Research Scholars, Lisbon, Portugal, 19 – 22 June 2008
  • The EMBO Meeting 2009, Amsterdam, the Netherlands, August 29– September 1, 2009
  • 37th Annual Conference on Yeasts, Smolenice, Bratislava, Slovak Republic, May 13 – 15, 2009
  • Central-Eastern European INSTRUCT Meeting, Budapest, Hungary, March 29 – April 1, 2009
  • DNA Damage Response and Repair Mechanism, April 20 – 23, 2009, Crete, Greece
  • Recombination & connections to SUMO and Ubiguitin modifications, Castelvecchio Pascoli (Lucca), Italy, May 17 – 21, 2010
  • EMBO Young Investigator Sectoral Meeting - 3rd YIP Genome Integrity Forum, Madrid, Spain, September 23 – 24, 2010
  • EMBO meeting: 25th International Conference on Yeast Genetics and Molecular Biology, Olszty-Kortowo, Poland June 11 – 16, 2011
  • EMBO workshop: Recombination Mechanisms and Genome Instability, Jerez de la Frontera, Spain, May 21 – 25, 2012
  • 6th DNA Repair Workshop, Smolenice, Bratislava, Slovak Republic, June 3-7, 2012
  • Structure-specific nucleases in DNA replication and repair, Côte d'Azur, France September 16 – 20, 2012
  • FEBS workshop – Nucleotide excision repair and interstrand crosslink repair – from molecules to man, Smolenice, Slovakia, June 9 – 13, 2013
  • FASEB Science Research Conferences Genetic Recombination and Genome Rearrangements, Steamboat Springs, Denver Colorado, USA, July 20 – 27, 2013
  • The FEBS EMBO 2014 Conference, Paris, France, September 1 – 4, 2014
  • ABCAM, Mechanisms of Recombination, Alicante, Spain May 19 – 23, 2014
  • EMBO YIP sectoral genome integrity meeting, Strasbourg, France, April 19 – 22, 2015
  • EMBO workshop: Modern DNA concepts and tools for safe gene transfer and modification, Université d’Evry, France, March 29 - April 2, 2015
  • EMBO YIP Sectoral meeting, Genomic Integrity Forum 2016, Sevilla, Spain, April 3 – 5, 2016
  • ABCAM, Mechanisms of Recombination 2016, Alicante, Spain, May 16 – 20 2016
  • 7th DNA Repair Workshop, Smolenice Castle, Slovak Republic, May 22 - 26, 2016
    International seminars:
  • Institute of Molecular Oncology, Italy, November 11, 2005
  • Cancer Research UK, Clare Hall Laboratories, November 25, 2010
  • Institute of Molecular Pathology, Austria, January 27, 2011
  • Institut Curie, Paris, France, October 4 – 5, 2011
  • EMBO Young Investigator Sectoral Meeting - 5th YIP Genome Integrity Forum, Montpellier, France, November 14 – 15, 2012
  • University of Coppenhagen, Novo Nordisk Foundation Center for Protein Research, Dennmark, December 16, 2012
  • Institut Curie, Paris, France, December 5, 2013
  • University of Zűrich, Switzerland, April 6, 2013
  • Oslo University Hospital, Norway, November 6 - 7, 2011
  • Comenius University, Bratislava, Slovak Republic, December 5, 2014
  • University of Zűrich, Switzerland, June 4, 2014

    Supervisor of doctoral students/day of thesis defense
    Rakesh Aithal, Ph.D. (2017)
    Veronika Altmannová, Ph.D. (2012)
    Zdenka Hašanová, Ph.D. (2016)
    Melita Chavdarova, Ph.D. (2014)
    Peter Kolesár, Ph.D. (2013)
    Pounami Samadder, Ph.D. (2017)
    Marek Šebesta, Ph.D. (2013)

    Current doctoral students
    Raghib Ashraf
    Alexandra Sisáková
    Barbora Štefanovie

    Pregradual students/dates of graduation
    Ondrej Beláň, 14. 6. 2017
    Michaela Pospíšilová, 13. 6. 2017
    Hana Sedláčková, 1. 6. 2016
    Tereza Gerguri, 18. 6. 2015
    Peter Lenárt, 8. 6. 2015
    Hana Sedláčková, 16. 6. 2014
    Martin Pačesa, 16. 6. 2014
    Jan Zálešák, 14. 6. 2013
    Michal Jež, 18. 6. 2012
    Ivica Lehotská, 16. 6. 2011
    Marek Kučera, 16. 6. 2011
    Jan Zálešák, 13. 6. 2011
    Barbora Štefanovie, 7. 6. 2011
    Alexandra Sisáková, 17. 6. 2010
    Daniela Baumgartnerová, 17. 6. 2010
    Barbora Štefanovie, 16. 6. 2009
    Alexandra Sisáková, 23. 6. 2008
    Daniela Baumgartnerová, 23. 6. 2008
    Veronika Plešková, 16. 6. 2008
    Veronika Altmannová, Ph.D., 8. 6. 2007

    Other educational activities:
    Founder and head of Bioskop - scientific training center for public
Scientific and Research Activities
  • Finished grants
  • 2001-NATO Science Fellowship Program, PI, Function of human Rad51 paralogs in homologous recombination
  • 2003-2006 US DOD Postdoctoral Fellowship BC020457, 2 mil USD, Role of Rad51-mediated Interactions in Recombination
  • 2006-2008 EMBO/HHMI Startup grant, 0,2 mil EUR, Srs2 protein and its multi-functional role in recombination/repair processes
  • 2006-2008 Ministry of Education of the Czech Republic, ME888, PI, 2,0 mil CZK, Helicases and homologous recombination
  • 2005-2011 Ministry of Education of the Czech Republic, MSM0021622413, Co-PI, 250 mil CZK, Proteins in metabolism and interaction of organisms with the environment
  • 2006-2011 Ministry of Education of the Czech Republic, LC06030, Co-PI, 60 mil CZK, Biomolecular Centre
  • 2006-2012 Wellcome International Science Fellowship (WT076476), PI, 24 mil CZK, Role of BRCA2 in Homologous Recombination and Genome Maintenance
  • 2009-2011 Czech Science Foundation, GAČR 301/09/1917, PI, 4,0 mil CZK, Resolution of replication-recombination DNA intermediates and its role in genomic instability
  • 2009-2012 Czech Science Foundation, GAČR 203/09/H046, Co-PI, 4,3 mil CZK, Biochemistry on the crossroad between in silico and in vitro
  • 2010-2012 American Science Information Center, Ministry of Education of the Czech Republic ME10048, PI, 1,6 mil CZK, The roles of post-translational protein modification during DNA repair and recopmbination
  • 2008-2011 FP7 - 7th Framework Programme for Research and Development, Co-PI, 1,050 mil EURO, Program developing interdisciplinary research potential for the studies of biomolecular interactions (POSTBIOMIN).
  • 2009-2012 Ministry of Education of the Czech Republic, CZ.1.07/2.3.00/09.0186, Co-PI, 19,7 mil CZK, Mendel center for education in biology and biomedicine
  • 2012-2014 Ministry of Education of the Czech Republic, Co-PI, 35 mil CZK, Centre for pluripotent cells and genome instability research (PLURICELL)
  • 2012-2016 Czech Science Foundation, GAČR 207/12/2323, Co-PI, 17,6 mil CZK, Endonuclease and translocase activity in type I restriction-modification complexes
  • 2013-2016 FP7 - 7th Framework Programme for Research and Development, Co-PI, 4,559 mil EURO, Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge)

    Current funding
  • 2013-2017 Czech Science Foundation, GAČR 13-26629S, PI, 15.9 mil CZK, SUMO and genome stability
  • 2015-2017 Masaryk University / Research support program, MUNI/M/1894/2014, PI, 5 mil CZK, Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression
  • 2015-2018 Ministry of Health of the CR / Ministry of Health Research Programme, 15-33999A, Co-PI, 17 mil CZK, Development of novel small molecules anticancer compounds with synthetic lethal effect
  • 2017-2019 Czech Science Foundation, GAČR 17-17720S, PI, 9,3 mil CZK, Intrinsic properties of RAD51 filament and its biological regulations

Other activities
  • Referee for international journals:
  • EMBO Journal
  • Molecular Cell
  • PLoS Genetics
  • Nucleic Acids Research
  • PLos One
  • DNA repair
  • Cell cycle
  • JBC
  • Nature Communication
  • JCB
  • PNAS
  • Genes and Development and other

    Referee for grant agencies:
  • Czech Science Foundation
  • Scientific Grant Agency VEGA (Slovak Republic)
  • European Research Council Executive Agency (ERCEA) and other

    Organizer of scientific conferences and meetings:
  • Masaryk University – Mendel Lectures (Main Organizer), Brno, Czech Republic, (since 2002) http://mendellectures.muni.cz/
  • 1st EMBO Young Investigator Sectoral Meeting on DNA Repair, 6 - 8 November 2008, Prague, Czech Republic, (Main Organizer)
  • 2nd EMBO Young Investigator Sectoral Meeting on DNA Repair, 15 - 17 October 2009, Brno, Czech Republic, (Main Organizer)
  • EMBO DNA Repair Meeting, 2010, Brno, Czech Republic, (Main Organizer)
  • EMBO Workshop: Recombination Mechanisms &Genome Instability, 21th – 25th May, 2012, Jerez de la Frontera, Spain, (Organizer)
  • Anniversary Mendel Lectures, Brno, Czech Republic, 2012, (Main Organizer)
  • 6th EMBO Young Investigator Sectoral Meeting on DNA Repair - Genome Integrity Forum, March 26th – 28th, 2014, Mendel Museum, Brno, Czech Republic, (Main Organizer)
  • 5th Central European Genome Stability and Dynamics Meeting, October 9th - 10th, 2014, Mendel Museum, Brno, Czech Republic, (Main Organizer)
  • EMBO Conference: Structure-Specific Endonucleases in Genome Stability Meeting, November 4th – 6th, 2015, Museum of Applied Arts, Brno, Czech Republic, (Main Organizer) http://www.nucleases.eu/
  • 28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB), Prague, Czech republic, August 27 – September 1, 2017, http://www.yeast2017.cz/

    Membership and supervision in doctoral boards
  • member of doctoral board, Institute of Biophysics of the Czech Academy of Sciences
  • member of doctoral board, Medical Biology, Faculty of Medicine, Masaryk University
  • member of doctoral commitee, Biomolecular Chemistry, Faculty of Science, Masaryk University
  • supervisor within doctoral board of Medical Biology, Faculty of Medicine, Masaryk University
  • supervisor within Biomolecular Chemistry, Faculty of Science, Masaryk University

Honors
  • 2001 NATO Science Fellowship
    2003-2006 US DOD Postdoctoral Fellowship
    2005-2010 Wellcome International Science Fellowship
    2005-2008 EMBO/HHMI Startup Award
    2005-2008 Ministry of Education Youth and Sport of the Czech Republic Award
Publication summary (May 2017)
  • Number of papers (WOS): 72
    Times cited (WoS): 2556
    h-index (WoS): 26
    Cumulative IF: 442.164
Selected papers
  • ŠEBESTA, Marek, Madhusoodanan URULANGODI, Barbora ŠTEFANOVIE, Barnabas SZAKAL, Martin PAČESA, Michael LISBY, Dana BRANZEI and Lumír KREJČÍ. Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains. Nucleic Acids Research. Oxford: Oxford University Press, 2017, vol. 45, No 1, p. 215-230. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkw882. info
  • PARVANOV, Emil Damyanov, Hui TIAN, Timothy BILLINGS, Ruth L. SAXL, Catrina SPRUCE, Rakesh AITHAL, Lumír KREJČÍ, Kenneth PAIGEN and Petko M. PETKOV. PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Molecular Biology of the Cell. Bethesda: American Society for Cell Biology, 2017, vol. 28, No 3, p. 488-499. ISSN 1059-1524. Available from: https://dx.doi.org/10.1091/mbc.E16-09-0686. info
  • VASIANOVICH, Yulia, Veronika ALTMANNOVÁ, Oleksii KOTENKO, Matthew D. NEWTON, Lumír KREJČÍ and Svetlana MAKOVETS. Unloading of homologous recombination factors is required for restoring double-stranded DNA at damage repair loci. EMBO Journal. Hoboken: Wiley-Blackwell, 2017, vol. 36, No 2, p. 213-231. ISSN 0261-4189. Available from: https://dx.doi.org/10.15252/embj.201694628. info
  • SHEMESH, Keren, Marek ŠEBESTA, Martin PAČESA, Soumitra SAU, Alex BRONSTEIN, Oren PARNAS, Batia LIEFSHITZ, Česlovas VENCLOVAS, Lumír KREJČÍ and Martin KUPIEC. A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Research. Oxford: Oxford University Press, 2017, vol. 45, No 6, p. 3189-3203. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkw1348. info
  • BAKKAIOVA, Jana, María Victoria MARINI PALOMEQUE, Smaranda WILLCOX, Jozef NOSEK, Jack D. GRIFFITH, Lumír KREJČÍ and Lubomir TOMASKA. Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids. Bioscience Reports. London: Portland Press LTD, 2016, vol. 36, No 1, p. "nestránkováno", 13 pp. ISSN 0144-8463. Available from: https://dx.doi.org/10.1042/BSR20150275. info
  • PEVALA, Vladimír, Dominika TRUBAN, Jacob A. BAUER, Július KOŠŤAN, Nina KUNOVÁ, Jana BELLOVÁ, Marlene BRANDSTETTER, María Victoria MARINI PALOMEQUE, Lumír KREJČÍ, Ľubomír TOMÁŠKA, Jozef NOSEK and Eva KUTEJOVÁ. The structure and DNA-binding properties of Mgm101 from a yeast with a linear mitochondrial genome. Nucleic Acids Research. Oxford: Oxford University Press, 2016, vol. 44, No 5, p. 2227-2239. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkv1529. URL info
  • SAMADDER, Pounami, Rakesh AITHAL, Ondrej BELÁŇ and Lumír KREJČÍ. Cancer TARGETases: DSB Repair as a Pharmacological Target. Pharmacology & Therapeutics. Kidlington: Pergamon-Elsevier Science LTD, 2016, vol. 161, "May", p. 111-131. ISSN 0163-7258. Available from: https://dx.doi.org/10.1016/j.pharmthera.2016.02.007. URL info
  • SILVA, Sonia, Veronika ALTMANNOVÁ, Sarah LUKE-GLASER, Peter HENRIKSEN, Irene GALLINA, Xuejiao YANG, Chunaram CHOUDHARY, Brian LUKE, Lumír KREJČÍ and Michael LISBY. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes & Development. Cold Spring Harbor: Cold Spring Harbor Laboratory Pres, 2016, vol. 30, No 6, p. 700-717. ISSN 0890-9369. Available from: https://dx.doi.org/10.1101/gad.276204.115. info
  • KOLESÁR, Peter, Veronika ALTMANNOVÁ, Sonia SILVA, Michael LISBY and Lumír KREJČÍ. Pro-recombination Role of Srs2 Protein Requires SUMO (Small ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction. Journal of Biological Chemistry. Bethesda: American Society for Biochemistry and Molecular Biology Inc., 2016, vol. 291, No 14, p. 7594-7607. ISSN 0021-9258. Available from: https://dx.doi.org/10.1074/jbc.M115.685891. info
  • LÉNÁRT, Peter and Lumír KREJČÍ. DNA, the central molecule of aging. Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier Science BV, 2016, vol. 786, "April", p. 1-7. ISSN 0027-5107. Available from: https://dx.doi.org/10.1016/j.mrfmmm.2016.01.007. info
  • LYAKHOVICH, Alex, Dmitry GRAIFER, Barbora ŠTEFANOVIE and Lumír KREJČÍ. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. Biochimica et Biophysica Acta - Reviews on Cancer. Amsterdam: Elsevier Science BV, 2016, vol. 1865, No 2, p. 184-189. ISSN 0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2016.02.006. info
  • BURKOVICS, Peter, Lili DOME, Szilvia JUHASZ, Veronika ALTMANNOVÁ, Marek ŠEBESTA, Martin PAČESA, Kasper FUGGER, Claus Storgaard SORENSEN, Marietta Y.W.T. LEE, Lajos HARACSKA and Lumír KREJČÍ. The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis. Nucleic Acids Research. Oxford: Oxford University Press, 2016, vol. 44, No 7, p. 3176-3189. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkw024. info
  • SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA, Huat Bay BOON, Matilde E. LLEONART, Rama S VERMA, Lumír KREJČÍ and Alex LYAKHOVICH. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. Oncotarget. New York: Impact Journals, 2016, vol. 7, No 36, p. 58065-58074. ISSN 1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.11161. info
  • SILVA, Sonia, Veronika ALTMANNOVÁ, Nadine ECKERT-BOULET, Peter KOLESÁR, Irene GALLINA, Lisa HANG, Inn CHUNG, Milica ARNERIC, Xiaolan ZHAO, Line Due BURON, Uffe H. MORTENSEN, Lumír KREJČÍ and Michael LISBY. SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination. DNA Repair. Amsterdam: Elsevier Science BV, 2016, vol. 42, "neuvedeno", p. 11-25. ISSN 1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2016.04.001. info
  • TAYLOR, Martin R.G., Mário ŠPÍREK, Chu Jian MA, Raffaella CARZANIGA, Tohru TAKAKI, Lucy M. COLLINSON, Eric C. GREENE, Lumír KREJČÍ and Simon J. BOULTON. A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling. Molecular Cell. Cambridge: Cell Press, 2016, vol. 64, No 5, p. 926-939. ISSN 1097-2765. Available from: https://dx.doi.org/10.1016/j.molcel.2016.10.020. info
  • LENÁRT, Peter and Lumír KREJČÍ. Reprint of "DNA, the central molecule of aging". Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier Science BV, 2016, vol. 788, June, p. 25-31. ISSN 0027-5107. Available from: https://dx.doi.org/10.1016/j.mrfmmm.2016.04.002. info
  • SARANGI, Prabha, Roland STEINACHER, Veronika ALTMANNOVÁ, Qiong FU, Tanya T. PAULL, Lumír KREJČÍ, Matthew WHITBY and Xiaolan ZHAO. Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein. PLoS Genetics. San Francisco, California, United States: Public Library Science, 2015, vol. 11, No 1, p. 1-12. ISSN 1553-7390. Available from: https://dx.doi.org/10.1371/journal.pgen.1004899. info
  • CHAVDAROVA, Melita, María Victoria MARINI PALOMEQUE, Alexandra SISÁKOVÁ, Hana SEDLÁČKOVÁ, Dana VIGAŠOVÁ, Steven J. BRILL, Michael LISBY and Lumír KREJČÍ. Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates. Nucleic Acids Research. Oxford: Oxford Press, 2015, vol. 43, No 7, p. 3626-3642. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkv198. info
  • SEDLÁČKOVÁ, Hana, Barbora CECHOVA, Jarmila MLČOUŠKOVÁ and Lumír KREJČÍ. RECQ4 selectively recognizes Holliday junctions. DNA Repair. Amsterdam: ELSEVIER SCIENCE BV, 2015, vol. 30, "neuvedeno", p. 80-89. ISSN 1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2015.02.020. info
  • TAYLOR, Martin R. G., Mário ŠPÍREK, Kathy R. CHAURASIYA, Jordan D. WARD, Raffaella CARZANIGA, Xiong YU, Edward H. EGELMAN, Lucy M. COLLINSON, David RUEDA, Lumír KREJČÍ and Simon J. BOULTON. Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination. Cell. Cambridge: Cell Press, 2015, vol. 162, No 2, p. 271-286. ISSN 0092-8674. Available from: https://dx.doi.org/10.1016/j.cell.2015.06.015. info
  • VRBSKÝ, Jan, Tamás TEREH, Sergiy KYRYLENKO, Petr DVOŘÁK and Lumír KREJČÍ. MEK and TGF-beta Inhibition Promotes Reprogramming without the Use of Transcription Factor. Plos one. San Francisco: Public Library of Science, 2015, vol. 10, No 6, p. "e0127739", 16 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0127739. info
  • BOLOGNA, Serena, Veronika ALTMANNOVÁ, Emanuele VALTORTA, Christiane KOENIG, Prisca LIBERALI, Christian GENTILI, Dorothea ANRATHER, Gustav AMMERER, Lucas PELKMANS, Lumír KREJČÍ and Stefano FERRARI. Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle. Philadelohia: TAYLOR & FRANCIS INC, 2015, vol. 14, No 15, p. 2439-2450. ISSN 1538-4101. Available from: https://dx.doi.org/10.1080/15384101.2015.1060381. info
  • URULANGODI, Madhusoodanan, Marek ŠEBESTA, Demis MENOLFI, Barnabas SZAKAL, Julie SOLLIER, Alexandra SISÁKOVÁ, Lumír KREJČÍ and Dana BRANZEI. Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication. Genes and Development. New York: Cold Spring Harbor Laboratory Press, 2015, vol. 29, No 19, p. 2067-2080. ISSN 0890-9369. Available from: https://dx.doi.org/10.1101/gad.265629.115. info
  • KLISZCZAK, Maciej, Hana SEDLÁČKOVÁ, Ganesha P. PITCHAI, Werner W. STREICHER, Lumír KREJČÍ and Ian D. HICKSON. Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget. New York: Impact Journals LLC, 2015, vol. 6, No 38, p. 40464-40479. ISSN 1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.6342. info
  • BURKOVICS, Peter, Marek ŠEBESTA, David BALOGH, Lajos HARACSKA and Lumír KREJČÍ. Strand invasion by HLTF as a mechanism for template switch in fork rescue. Nucleic Acids Research. Oxford: Oxford University Press, 2014, vol. 42, No 3, p. 1711-1720. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkt1040. info
  • SARANGI, Prabha, Zdenka BARTOŠOVÁ, Veronika ALTMANNOVÁ, Cory HOLLAND, Melita CHAVDAROVA, Sang Eun LEE, Lumír KREJČÍ and Xiaolan ZHAO. Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association. Nucleic Acids Research. Oxford University Press, 2014, vol. 42, No 10, p. 6393-6404. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gku300. info
  • BARTOŠOVÁ, Zdenka and Lumír KREJČÍ. Nucleases in homologous recombination as targets for cancer therapy. FEBS Letters. Amsterdam: Elsevier Science, 2014, vol. 588, No 15, p. 2446-2456. ISSN 0014-5793. Available from: https://dx.doi.org/10.1016/j.febslet.2014.06.010. info
  • SARANGI, Prabha, Veronika ALTMANNOVÁ, Cory HOLLAND, Zdenka BARTOŠOVÁ, Fanfan HAO, Dorothea ANRATHER, Gustav AMMERER, Sang Eun LEE, Lumír KREJČÍ and Xiaolan ZHAO. A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions. Cell Reports. CAMBRIDGE, Spojené státy americké: Cell Press, 2014, vol. 9, No 1, p. 143-152. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2014.08.054. info
  • ZÁLEŠÁK, Jan, Morgane LOURDIN, Lumír KREJČÍ, Jean-Francois CONSTANT and Muriel JOURDAN. Structure and Dynamics of DNA Duplexes Containing a Cluster of Mutagenic 8-Oxoguanine and Abasic Site Lesions. Journal of Molecular Biology. London: Academic Press, 2014, vol. 426, No 7, p. 1524-1538. ISSN 0022-2836. Available from: https://dx.doi.org/10.1016/j.jmb.2013.12.022. URL info
  • VIGAŠOVÁ, Dana, Prabha SARANGI, Peter KOLESÁR, Danusa VLASAKOVA, Zuzana SLEZÁKOVÁ, Veronika ALTMANNOVÁ, Fedor NIKULENKOV, Dorothea ANRATHER, Rainer GITH, Xiaolan ZHAO, Miroslav CHOVANEC and Lumír KREJČÍ. Lif1 SUMOylation and its role in non-homologous end-joining. Nucleic Acids Research. Oxford: Oxford Press, 2013, vol. 41, No 10, p. 5341-5353. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkt236. URL info
  • BURKOVICS, Peter, Marek ŠEBESTA, Alexandra SISÁKOVÁ, Nicolas PLAULT, Valeria SZUKACSOV, Thomas ROBERT, Lajos PINTER, María Victoria MARINI PALOMEQUE, Peter KOLESÁR, Lajos HARACSKA, Serge GANGLOFF and Lumír KREJČÍ. Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis. EMBO JOURNAL. NEW YORK: NATURE PUBLISHING GROUP, 2013, vol. 32, No 5, p. 742-755. ISSN 0261-4189. Available from: https://dx.doi.org/10.1038/emboj.2013.9. info
  • ŠEBESTA, Marek, Peter BURKOVICS, Szilvia JUHASZ, Sufang ZHANG, Judit SZABO, Marietta Y. W. T. LEE, Lajos HARACSKA and Lumír KREJČÍ. Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair. AMSTERDAM: ELSEVIER SCIENCE BV, 2013, vol. 12, No 9, p. 691-698. ISSN 1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2013.05.001. info
  • BURGESS, Rebecca C., Marek ŠEBESTA, Alexandra SISÁKOVÁ, María Victoria MARINI PALOMEQUE, Michael LISBY, Jiří DAMBORSKÝ, Hannah KLEIN, Rodney ROTHSTEIN and Lumír KREJČÍ. The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination. Plos One. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2013, vol. 8, No 12, p. "e82630", 10 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0082630. info
  • MARINI PALOMEQUE, María Victoria and Lumír KREJČÍ. Unwinding of synthetic replication and recombination substrates by Srs2. DNA Repair. ELSEVIER, 2012, vol. 11, No 10, p. 789-798. ISSN 1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2012.05.007. URL info
  • KOLESÁR, Peter, Prabha SARANGI, Veronika ALTMANNOVÁ, Xiaolan ZHAO and Lumír KREJČÍ. Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation. Nucleic Acids Research. Oxford: Oxford University Press, 2012, vol. 40, No 16, p. 7831-7843. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gks484. NAR info
  • ALTMANNOVÁ, Veronika, Peter KOLESÁR and Lumír KREJČÍ. SUMO Wrestles with Recombination. Biomolecules. Basel, Switzerland: MDPI AG, 2012, vol. 2, No 3, p. 350-375. ISSN 2218-273X. Available from: https://dx.doi.org/10.3390/biom2030350. Biomolecules info
  • KREJČÍ, Lumír, Veronika ALTMANNOVÁ, Mário ŠPÍREK and Xiaolan ZHAO. Homologous recombination and its regulation. Nucleic Acids Research. Oxford, UK: Oxford Press, 2012, vol. 40, No 13, p. 5795-5818. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gks270. info
  • ŠEBESTA, Marek, Peter BURKOVICS, Lajos HARACSKA and Lumír KREJČÍ. Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities. DNA Repair. 2011, vol. 10, No 6, p. 567-576. ISSN 1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2011.03.003. info
  • MARINI PALOMEQUE, María Victoria and Lumír KREJČÍ. Srs2: the Odd-Job Man in DNA repair. DNA Repair. ELSEVIER, 2010, vol. 9, No 3, 3 pp. ISSN 1568-7864. info
  • MARCO, Saporano, Callahan DEVON, Zheng XIUZHONG, Lumír KREJČÍ, Haber JAMES, Klein HANNAH and Liberi GIORDANO. Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote. PLoS Genetics. Public Library of Science, 2010, vol. 2010, No 2, 8 pp. ISSN 1553-7390. info
  • ALTMANNOVÁ, Veronika, Nadine ECKERT-BOULET, Milica ARNERIC, Peter KOLESÁR, Radka CHALOUPKOVÁ, Jiří DAMBORSKÝ, Patrick SUNG, Xiaolan ZHAO, Michael LISBY and Lumír KREJČÍ. Rad52 SUMOylation affects the efficiency of the DNA repair. Nucleic Acids Research. Oxford University Press, 2010, vol. 38, No 6, 9 pp. ISSN 0305-1048. info
  • MATULOVÁ, Petra, María Victoria MARINI PALOMEQUE, RC BURGESS, Alexandra SISÁKOVÁ, Youngho KWON, Rodney ROTHSTEIN, Patrick SUNG and Lumír KREJČÍ. Co-operativity of Mus81-Mms4 with Rad54 in the resolution of recombination and replication intermediates. J Biol Chem. 2009, vol. 284, No 12, p. 7733-7745, 12 pp. ISSN 1083-351X. info
  • PRAKASH, Rohit, D. SATORY, E. DRAY, A. PAPUSHA, J. SCHELLER, W. KRAMER, Lumír KREJČÍ, Hannah KLEIN, J.E. HABER, Patrick SUNG and Grzegorz IRA. Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev. 2009, vol. 23, No 1, p. 67-79, 12 pp. ISSN 1549-5477. info
  • ANTONY, Edwin, Eric J. TOMKO, Qi XIAO, Lumír KREJČÍ, Timothy M. LOHMAN and Tom ELLENBERGER. Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA. Molecular Cell. 2009, vol. 35, No 1, p. 105-115, 10 pp. ISSN 1097-2765. info
  • BURGESS, R.C., Michael LISBY, Veronika ALTMANNOVÁ, Lumír KREJČÍ, Patrick SUNG and Rodney ROTHSTEIN. Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo. Journal of Cell Biology. 2009, vol. 185, No 6, p. 969-981, 12 pp. ISSN 0021-9525. info
  • SEONG, Changhyuan, Siera COLAVITO, YongHo KWON, Patrick SUNG and Lumír KREJČÍ. Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase. J Biol Chem. 2009, vol. 254, No 12, p. 104-111, 7 pp. ISSN 0021-9258. info
  • SIERRA, Colavito, Macris-Kiss MARGARET, Seong CHANGHYUN, Gleeson OLIVE, Greene ERIC C., Klein HANNAH L., Krejci LUMIR and Sung PATRICK. Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption. Nucleic Acids Research. ENGLAND: OXFORD UNIV PRESS, 2009, vol. 20, No 37, p. 6754-64, 10 pp. ISSN 0305-1048. URL info
  • SEONG, Changhyuan, Michael SEHORN, Iben PLATE, Idina SHI, Binway SONG, Peter CHI, Uffe MORTENSEN, Patrick SUNG and Lumír KREJČÍ. Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52. J. Biol. Chem. 2008, vol. 18, No 283, p. 12166-74, 8 pp. ISSN 0021-9258. URL info
  • PLATE, Iben, SC HALLWYL, Idina SHI, Lumir KREJCI, C. MULLER, L. ALBERTSEN, Patrick SUNG and Uffe MORTENSEN. Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. J. Biol. Chem. 2008, vol. 24, No 283, p. 29077-, 8 pp. ISSN 0021-9258. URL info
  • KREJČÍ, Lumír. DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain. Paris: Institute Curie, 2006. URL info
  • FILLIPO, Joseph, Peter CHI, Lumír KREJČÍ and Patrick SUNG. Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide. J. Biol. Chem. 2006, vol. 17, No 281, p. 11649-11657, 8 pp. ISSN 0021-9258. URL info
  • MACRIS, MA, Lumír KREJČÍ, W. BUSSEN, A. SHIMAMOTO and Patrick SUNG. Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. DNA Repair. 2006, vol. 5, No 2, 8 pp. ISSN 1568-7864. info
  • KREJCI, Lumir, Julia ETCHIN, San Joe FILIPPO and Patrick SUNG. DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain (DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA binding Domain). In Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting. Philadelphia, USA: U.S. Army Medical Research and Materiel Command, 2005, 89 pp. URL info
  • CHEN, ling, Kelly TRUJILLO, Stephen VAN KOMEN, Dong ROH, Lumír KREJČÍ, Kevin LEWIS, Mike RESNICK, Patrick SUNG and Alan TOMKINSON. Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2005, vol. 280, No 4, p. 2620-7, 7 pp. ISSN 0021-9258. URL info
  • PRAKASH, Rohit, Lumír KREJČÍ, Stephen VAN KOMEN, Anke SCHURER, Wilfried KRAMER and Patrick SUNG. Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2005, vol. 280, No 9, p. 7854-60, 6 pp. ISSN 0021-9258. URL info
  • PAPOULI, Efterpi, Shuhua CHEN, Adelina DAVIES, Diana HUTTNER, Lumir KREJCI, Patrick SUNG and Helle ULRICH. Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Molecular Cell. 2005, vol. 19, No 1, p. 123-33, 10 pp. ISSN 1097-2765. URL info
  • KREJČÍ, Lumír, Margaret MACRIS, Stephen VAN KOMEN, Jane VILLEMAIN, Tom ELLENBERGER, Hannah KLEIN and Patrick SUNG. Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2004, vol. 279, No 22, p. 23193-9, 6 pp. ISSN 0021-9258. URL info
  • KREJČÍ, Lumír, Stephen VAN KOMEN, Ying LI, Jane VILLEMAIN, Sredhar REDDY, Hannah KLEIN, Tom ELLENBERGER and Patrick SUNG. DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature. Lodon, UK: Nature Publishing Group, 2003, vol. 423, No 6937, p. 305-9, 4 pp. ISSN 0028-0836. info
  • SUNG, Patrick, Lumír KREJČÍ, Stephen VAN KOMEN and Michael SEHORN. Rad51 recombinase and recombination mediators. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2003, vol. 278, No 44, p. 42729-32, 3 pp. ISSN 0021-9258. info
  • VAN KOMEN, Stephen, Sredhar REDDY, Lumír KREJČÍ, Hannah KLEIN and Patrick SUNG. ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2003, vol. 278, No 45, p. 44331-7, 6 pp. ISSN 0021-9258. info
  • KREJČÍ, Lumír, Ling CHEN, Stephen VAN KOMEN, Patrick SUNG and Alan TOMKINSON. Mending the break: two DNA double-strand break repair machines in eukaryotes. Prog Nucleic Acid Res Mol Biol. 2003, vol. 2003, No 74, p. 159-201, 41 pp. URL info
  • KREJCI, Lumir and Patrick SUNG. RPA not that different from SSB. Structure. USA: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMB, 2002, vol. 10, No 5, p. 601-2, 1 pp. ISSN 0969-2126. info
  • KREJCI, Lumir and Patrick SUNG. Of forks and ends. Trends in biochemical sciences. Cambridge: Elsevier Science, 2002, vol. 27, No 5, p. 225-6, 1 pp. ISSN 0968-0004. info
  • KREJCI, Lumir, Binwei SONG, Wendy BUSSEN, Rodney ROTHSTEIN, Uffe MORTENSEN and Patrick SUNG. Interaction with Rad51 is indispensable for recombination mediator function of Rad52. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2002, vol. 277, No 42, p. 40132-41, 9 pp. ISSN 0021-9258. info
  • KREJČÍ, Lumír, Jiří DAMBORSKÝ, B. THOMSEN, M. DUNO and C. BENDIXEN. Molecular dissection of interactions between Rad51 and members of the recombination-repair group (olecular dissection of interactions between Rad51 and members of the recombination-repair group). Molecular and Cellular Biology. 2001, vol. 21, No 3, p. 966-976. ISSN 0270-7306. info
  • KREJČÍ, Lumír, Bo THOMSEN, Morten DUNO, Ole WESTERGAARD and Christian BENDIXEN. Homomeric Interaction Of the Mouse Rad52 Protein. J.Biomol. Struct. Dyn. USA: Adenine press, 2000, vol. 17, No 6, p. 1170. ISSN 0739-1102. info
  • DUNO, Morten, Bo THOMSEN, Ole WESTERGAARD, Lumír KREJČÍ and Christian BENDIXEN. Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1. Mol Gen Genet. 2000, vol. 264, 1-2, p. 89-97, 8 pp. ISSN 1617-4615. info
  • DUNO, M., C. BENDIXEN, Lumír KREJČÍ and B. THOMSEN. Targeted deletions created in yeast vectors by recombinational excision. Nucletic Acids Research. G. B.: Oxford University Press, 1999, vol. 27, No 8, p. e1, 1 pp. ISSN 0305-1048. info

2017/08/25

Curriculum Vitae: doc. Mgr. Lumír Krejčí, Ph.D. (učo 18098), version: English(3), last update: 2017/08/25 17:01, L. Krejčí

Another Variant: Czech(1)