Životopis

Curriculum vitae

M.Sc. Pavel MÜLLER, Ph.D., HDR

• Born in Brno (1981), Czech Republic
  2 daughters (twins, born 2009)
  Living in Paris, France (since 2010)
  Nationalities: Czech and French
  Languages spoken: Czech, English, German, French & Slovak (C2-C1), Bulgarian (B2), Polish & Russian (B1-A2), Italian, Spanish & Serbo-croatian (passive knowledge only, A1-A2)

Institution

• Institute for Integrative Biology of the Cell (I2BC), France

Current position(s)

• CNRS Researcher

Degrees and academic qualification

• HDR (Habilitation à Diriger des Recherches) from Université Paris-Saclay, FR (2021)
  Ph.D. in physical chemistry from Universität Basel (research group of Prof. Jakob Wirz), CH (2007)
  M.Sc. in organic chemistry from Masaryk University (research group of Prof. Petr Klán), CZ (2004)

Professional experience

• Postdoctoral fellow, Universität Basel, CH (2008-2010)
  Postdoctoral fellow, Sorbonne / Pierre and Marie Curie University, FR (2010-2012)
  Postdoctoral fellow, CEA Saclay (French Alternative Energies and Atomic Energy Commission), FR (2012-2016)

Teaching activities

• Tutorials in chemical thermodynamics and kinetics (in English and German), Universität Basel, CH (2004-2006)
  Laboratory course in general chemistry (in German), Universität Basel, CH (2005-2007)
  Training of undergraduate students in biochemistry/biophysics (in English and French), Sorbonne (Pierre and Marie Curie University) & Univ. Paris-Saclay, FR (2010-present)

Research activities

• Light-induced electron and proton transfer in peptides and proteins
  Transient absorption spectroscopy
  Photochemistry, photobiophysics

Professional stays abroad during M.Sc. studies

• Socrates/Erasmus - Université de Paris Sud XI, Orsay, France (2003)
  Stevens’ Summer Research Fellowship - University of Missouri-Columbia, USA (2003)

Most significant professional accomplishments

• Dean's Award for an outstanding academic performance and research; Masaryk University, Czech Republic (2004)
  Ph.D. with the distinction 'Summa Cum Laude' (with highest honor); University of Basel, Switzerland (2007)
  Recruited as a permanent researcher by the CNRS; France (2016)

Major publications

• ALEKSANDROV, Alexey, Adeline BONVALET, Pavel MÜLLER, Damien SORIGUÉ, Fred BEISSON, Laura ANTONUCCI, Xavier SOLINAS, Manuel JOFFRE a Marten VOS. Catalytic Mechanism of Fatty Acid Photodecarboxylase: on the Detection and Stability of the Initial Carbonyloxy Radical Intermediate. Angewandte Chemie International Edition. WEINHEIM (GERMANY): Verlag Chemie, 2024, s. e202403548. ISSN 1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.202401376. URL info
• SAMIRE, Poutoum P., Bo ZHUANG, Bertrand LÉGERET, Ángel BACA-PORCEL, Gilles PELTIER, Damien SORIGUÉ, Alexey ALEKSANDROV, Frédéric BEISSON a Pavel MÜLLER. Autocatalytic Effect Boosts the Production of Medium-Chain Hydrocarbons by Fatty Acid Photodecarboxylase. Science Advances. AAAS, 2023, roč. 9, č. 13, s. eadg3881, 11 s. ISSN 2375-2548. Dostupné z: https://dx.doi.org/10.1126/sciadv.adg3881. URL info
• RENOUARD, Emilie, Magdalena NOWINSKA, Fabien LACOMBAT, Pascal PLAZA, Pavel MÜLLER a Agathe ESPAGNE. Multiscale Transient Absorption Study of the Fluorescent Protein Dreiklang and Two Point Variants Provides Insight into Photoswitching and Nonproductive Reaction Pathways. J. Phys. Chem. Lett. ACS, 2023, roč. 14, s. 6477–6485. ISSN 1948-7185. URL info
• MAESTRE-REYNA, Manuel, Wang PO-HSUN, Eriko NANGO, Yuhei HOSOKAWA, Martin SAFT, Antonia FURRER, Yang CHENG-HAN, Eka Putra Gusti Ngurah PUTU, Wu WEN-JIN, Emmerich HANS-JOACHIM, Nicolas CARAMELLO, Sophie FRANZ-BADUR, Chao YANG, Sylvain ENGILBERGE, Maximilian WRANIK, Hannah Louise GLOVER, Tobias WEINERT, Wu HSIANG-YI, Lee CHENG-CHUNG, Huang WEI-CHENG, Huang KAI-FA, Chang YAO-KAI, Liao JIAHN-HAUR, Weng JUI-HUNG, Wael GAD, Chang CHIUNG-WEN, Allan H PANG, Yang KAI-CHUN, Lin WEI-TING, Chang YU-CHEN, Dardan GASHI, Emma BEALE, Dmitry OZEROV, Karol NASS, Gregor KNOPP, Philip JM JOHNSON, Claudio CIRELLI, Chris MILNE, Camila BACELLAR, Michihiro SUGAHARA, Shigeki OWADA, Yasumasa JOTI, Ayumi YAMASHITA, Rie TANAKA, Tomoyuki TANAKA, Fangjia LUO, Kensuke TONO, Wiktoria ZARZYCKA, Pavel MÜLLER, Maisa Alkheder ALAHMAD, Filipp BEZOLD, Valerie FUCHS, Petra GNAU, Stephan KIONTKE, Lukas KORF, Viktoria REITHOFER, Christian Joshua ROSNER, Elisa Marie SEILER, Mohamed WATAD, Laura WEREL, Roberta SPADACCINI, Junpei YAMAMOTO, So IWATA, Dongping ZHONG, Jörg STANDFUSS, Antoine ROYANT, Yoshitaka BESSHO, Essen LARS-OLIVER a Tsai MING-DAW. Visualizing the DNA repair process by a photolyase at atomic resolution. Science. USA: AAAS, 2023, roč. 382, č. 6674, s. eadd7795. ISSN 0036-8075. Dostupné z: https://dx.doi.org/10.1126/science.add7795. URL info
• BRETTEL, Klaus, Pavel MÜLLER a Junpei YAMAMOTO. Kinetics of Electron Returns in Successive Two-Photon DNA Repair by (6-4) Photolyase. ACS Catalysis. American Chemical Society, 2022, roč. 12, s. 3041–3045. ISSN 2155-5435. Dostupné z: https://dx.doi.org/10.1021/acscatal.2c00492. URL info
• HOSOKAWA, Yuhei, Pavel MÜLLER, Hirotaka KITOH-NISHIOKA, Shigenori IWAI a Junpei YAMAMOTO. Limited solvation of an electron donating tryptophan stabilizes a photoinduced charge-separated state in plant (6-4) photolyase. Nature Scientific Reports. Nature Publishing Group, 2022, roč. 12, s. 5084. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-08928-0. URL info
• LECOMBAT, Fabien, Agathe ESPAGNE, Nadia DOZOVA, Pascal PLAZA, Pavel MÜLLER, Hans-Joachim EMMERICH, Martin SAFT a Lars-Oliver ESSEN. Ultrafast photoreduction dynamics of a new class of CPD photolyases. Photochemical & Photobiological Sciences. Springer, 2021, roč. 20, č. 6, s. 733-746. ISSN 1474-905X. Dostupné z: https://dx.doi.org/10.1007/s43630-021-00048-4. URL info
• SORIGUÉ, Damien, Kyprianos HADJIDEMETRIOU, Stephanie BLANGY, G GOTTHARD, A BONVALET, N COQUELLE, P SAMIRE, A ALEKSANDROV, L ANTONUCCI, A BENACHIR, S BOUTET, M BYRDIN, M CAMMARATA, S CARBAJO, S CUINÉ, R B DOAK, L FOUCAR, A GOREL, M GRÜNBEIN, E HARTMANN, R HIENERWADEL, M HILPERT, M KLOOS, T J LANE, B LÉGERET, P LEGRAND, Y LI-BEISSON, S L Y MOULIN, D NURIZZO, G PELTIER, G SCHIRÒ, R L SHOEMAN, M SLIWA, X SOLINAS, B ZHUANG, T R M BARENDS, JP COLLETIER, M JOFFRE, A ROYANT, Catherine BERTHOMIEU, Martin WEIK, Tatiana DOMRATCHEVA, Klaus BRETTEL, Marten H. VOS, Ilme SCHLICHTING, Pascal ARNOUX, Pavel MÜLLER a Fred BEISSON. Mechanism and dynamics of fatty acid photodecarboxylase. Science. AAAS, 2021, roč. 372, č. 6538, s. eabd5687. ISSN 0036-8075. Dostupné z: https://dx.doi.org/10.1126/science.abd5687. URL info
• LACOMBAT, Fabien, Agathe ESPAGNE, Nadia DOZOVA, Pascal PLAZA, Pavel MÜLLER, Klaus BRETTEL, Sophie FRANZ-BADUR a Lars-Oliver ESSEN. Ultrafast Oxidation of a Tyrosine by Proton-Coupled Electron Transfer Promotes Light Activation of an Animal-like Cryptochrome. J. Am. Chem. Soc. Washington: American Chemical Society, 2019, roč. 141, č. 34, s. 13394-13409. ISSN 0002-7863. Dostupné z: https://dx.doi.org/10.1021/jacs.9b03680. URL info
• MÜLLER, Pavel, Elisabeth IGNATZ, Stephan KIONTKE, Klaus BRETTEL a Lars-Oliver ESSEN. Sub-nanosecond tryptophan radical deprotonation mediated by a protein-bound water cluster in class II DNA photolyases. Chemical Science. The Royal Socety of Chemistry, 2018, roč. 9, s. 1200-1212. Dostupné z: https://dx.doi.org/10.1039/C7SC03969G. URL info
• SORIGUÉ, Damien, Bertrand LÉGERET, Stéphan CUINÉ, Stéphanie BLANGY, Solene MOULIN, Emmanuelle BILLON, Pierre RICHAUD, Sabine BRUGIÈRE, Didier NURIZZO, Pavel MÜLLER, Klaus BRETTEL, David PIGNOL, Pascal ARNOUX, Younghua LI-BEISSON, Gilles PELTIER a Fred BEISSON. An algal photoenzyme converts fatty acids to hydrocarbons. Science. AAAS, 2017, roč. 357, č. 6354, s. 903-907. ISSN 0036-8075. Dostupné z: https://dx.doi.org/10.1126/science.aan6349. URL info
• YAMAMOTO, Junpei, Kohei SHIMIZU, Takahiro KANDA, Yuhei HOSOKAWA, Shigenori IWAI, Pascal PLAZA a Pavel MÜLLER. Loss of fourth electron-transferring tryptophan in animal (6–4) photolyase impairs DNA repair activity in bacterial cells. Biochemistry. Washington: American Chemical Society, 2017, roč. 56, č. 40, s. 5356-5364. ISSN 0006-2960. Dostupné z: https://dx.doi.org/10.1021/acs.biochem.7b00366. URL info
• CAILLIEZ, Fabien, Pavel MÜLLER, Thiago FIRMINO, Pascal PERNOT a Aurélien de la LANDE. Energetics of Photoinduced Charge Migration within the Tryptophan Tetrad of an Animal (6-4) Photolyase. J. Am. Chem. Soc. Washington: American Chemical Society, 2016, roč. 138, č. 6, s. 1904-1915. ISSN 0002-7863. Dostupné z: https://dx.doi.org/10.1021/jacs.5b10938. URL info
• MÜLLER, Pavel a Jean-Pierre BOULY. Searching for the Mechanism of Signalling by Plant Photoreceptor Cryptochrome. FEBS Letters. Elsevier, 2015, roč. 589, s. 189-192. ISSN 0014-5793. Dostupné z: https://dx.doi.org/10.1016/j.febslet.2014.12.008. URL info
• MÜLLER, Pavel, Junpei YAMAMOTO, Ryan MARTIN, Shigenori IWAI a Klaus BRETTEL. Discovery and functional analysis of a 4th electron-transferring tryptophan conserved exclusively in animal cryptochromes and (6-4) photolyases. Chemical Communications. Cambridge: The Royal Society of Chemistry (RSC), 2015, roč. 51, s. 15502-15505. ISSN 1359-7345. Dostupné z: https://dx.doi.org/10.1039/C5CC06276D. URL info
• MÜLLER, Pavel, Jean-Pierre BOULY, Kenichi HITOMI, Véronique BALLAND, Elizabeth GETZOFF, Thorsten RITZ a Klaus BRETTEL. ATP Binding Turns Plant Cryptochrome Into an Efficient Natural Photoswitch. Scientific Reports. Nature Publishing Group, 2014. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep05175. URL info
• CAILLIEZ, Fabien, Pavel MÜLLER, Michaël GALLOIS a Aurélien DE LA LANDE. ATP binding and aspartate protonation enhance photoinduced electron transfer within plant cryptochrome. J. Am. Chem. Soc. Washington: American Chemical Society, 2014, roč. 136, s. 12974-12986. ISSN 0002-7863. Dostupné z: https://dx.doi.org/10.1021/ja506084f. URL info
• ŠEBEJ, Peter, Jürgen WINTNER, Pavel MÜLLER, Tomáš SLANINA, Jamaludin AL ANSHORI, Lovely ANGEL P. A., Petr KLÁN a Jakob WIRZ. Fluorescein Analogues as Photoremovable Protecting Groups Absorbing at 520 nm. Journal of Organic Chemistry. Columbus, OH, USA: the American Chemical Society, 2013, roč. 78, č. 5, s. 1833-1843. ISSN 0022-3263. Dostupné z: https://dx.doi.org/10.1021/jo301455n. URL info
• MÜLLER, Pavel a Klaus BRETTEL. [Ru(bpy)3]2+ as a Reference in Transient Absorption Spectroscopy: Differential Absorption Coefficients for Formation of the Long-Lived 3MLCT Excited State. Photochemical and Photobiological Sciences. Cambridge, United Kingdom: Royal Society of Chemistry, 2012, roč. 11, č. 4, s. 632 - 636. ISSN 1474-905X. Dostupné z: https://dx.doi.org/10.1039/C2PP05333K. URL info
• GAO, Jian, Pavel MÜLLER, Min WANG, Sonja ECKHARDT, Miriam LAUZ, Katharina FROMM a Bernd GIESE. Electron Transfer in Peptides: The Influence of Charged Amino Acids. Angewandte Chemie International Edition. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co., 2011. ISSN 1433-7851. URL info
• MÜLLER, Pavel a Margaret AHMAD. Light-Activated Cryptochrome Reacts With Molecular Oxygen To Form a Flavin–Superoxide Radical Consistent With Magnetoreception. J. Biol. Chem. The American Society for Biochemistry and Molecular Biology, Inc., 2011, roč. 286, č. 24, s. 21033-40, 8 s. ISSN 0021-9258. URL info
• THIAGARAJAN, Viruthachalam, Martin BYRDIN, Andre P M EKER, Pavel MÜLLER a Klaus BRETTEL. Kinetics of cyclobutane thymine dimer splitting by DNA photolyase directly monitored in the UV. Proceedings of the National Academy of Sciences of the United States of America. 2011, roč. 108, č. 23, s. 9402-07. ISSN 0027-8424. URL info
• WANG, Min, Jian GAO, Pavel MÜLLER a Bernd GIESE. Electron Transfer in Peptides with Cysteine and Methionine as Relay Amino Acids. Angewandte Chemie International Edition. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co., 2009. ISSN 1433-7851. URL info
• CANONICA, Silvio, Bruno HELLRUNG, Pavel MÜLLER a Jakob WIRZ. Aqueous Oxidation of Phenylurea Herbicides by Triplet Aromatic Ketones. Environmental Science & Technology. USA: The American Chemical Society, 2006. ISSN 0013-936X. URL info
• MÜLLER, Pavel, Andre LOUPY a Petr KLÁN. The electrodeless discharge lamp: a prospective tool for photochemistry. Part 6. Photochemistry of valerophenone and 4-nitroanisole in high-temperature water. Journal of Photochemistry and Photobiology A: Chemistry. Amsterdam, The Netherlands: Elsevier Science, 2005, roč. 172, s. 146-150. ISSN 1010-6030. URL info
• MÜLLER, Pavel, Petr KLÁN a Vladimír CÍRKVA. The electrodeless discharge lamp: a prospective tool for photochemistry. Part 5. Journal of Photochemistry and Photobiology A: Chemistry. Amsterdam, The Netherlands: Elsevier Science, 2004, roč. 171, č. 1, s. 51-57. ISSN 1010-6030. URL info
• MÜLLER, Pavel, Petr KLÁN a Vladimír CÍRKVA. The Electrodeless Discharge Lamp: A Prospective Tool for Photochemistry. Part 4: Temperature- and Envelope Material-Dependent Emission Characteristics. Journal of Photochemistry and Photobiology A: Chemistry. Amsterdam, The Netherlands: Elsevier Science, 2003, roč. 158, č. 1, s. 1-5. ISSN 1010-6030. URL info

2023/12/13