Životopis

Person Identification

• Doc. Ing. Michal Pásek, PhD., born on 20th August 1971 in Vyškov

Workplace

• Department of Physiology
  Faculty of Medicine
  Masaryk University
  Kamenice 5
  625 00 Brno
  Czech Republic

Employment Position

• Associate professor

Education and Academic Qualifications

• 2010: Assoc. Prof.: Cellular Biophysics, Technical University Brno, Use of computational modelling in the research of electrophysiological processes in cardiac cells
• 2000: PhD.: Cellular Biophysics, Technical University Brno, Computational modelling of physiological processes in cardiac cells: block of membrane channels
• 1995: MSc.: Applied Mechanics, Technical University Brno, Computational modelling of tension and deformation at cylindrical basins affected by pressure wave.

Employment

• 2011 to present: Associate Professor, Department of Physiology, Faculty of Medicine, Masaryk University, Brno
• 2000 to 2010: Lecturer, Department of Physiology, Faculty of Medicine, Masaryk University, Brno
• 1999 to present: Research worker, Institute of Thermomechanics ASCR - branch Brno

Pedagogical Activities

• Physiology - practicals, seminars, lectures

Scientific and Research Activities

• Computational modelling of biophysical processes in cardiac cells

Academical Stays

• 2003: two-week research stage at the Laboratory of Fundamental and Applied Bioenergetics (Prof. Valdur Saks), University of Joseph Fourier, Grenoble
• 2005: one-month research stage at the Department of Physiology and Pharmacology (Prof. Clive H. Orchard), University of Bristol, Bristol
• 2006: one-month research stage at the Department of Physiology and Pharmacology (Prof. Clive H. Orchard), University of Bristol, Bristol
• 2007: one-month research stage at the Department of Physiology and Pharmacology (Prof. Clive H. Orchard), University of Bristol, Bristol
• 2009: two-week research stage at the Department of Physiology and Pharmacology (Prof. Clive H. Orchard), University of Bristol, Bristol

Membeship

• 2012 to present: Member of the European Society of Cardiology
• 2005 to present: Member of the Physiological Society

Appreciation of Science Community

• 2007: The prize of the Institute of Thermomechanics ASCR for the study Pásek M. et al.: The functional role of cardiac T-tubules in a model of rat ventricular myocyte, Phil Trans R Soc A 2006;364:1187-1206
• 2005: The junior prize of the Institute of Thermomechanics ASCR for the study Pásek M. & Šimurda J.: Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells, Med Biol Eng Comput 2004;42:151-15
• 2002: The second prize at the Czech-French-Slovak Symposium “New Frontiers in Basic Cardiovascular Research” for the poster Pásek et al.: Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell
• 2002: The second prize at the Conference “Engineering Mechanics 2002” for the poster Pásek et al.: Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells
• 2000: Award of Prof. Valenta and Prof. Čihák in Biomechanics

Major Publications

• Pásek M., Šimurda J., Christé G.: Different densities of Na-Ca exchange current in t-tubular and surface membranes and their impact on cellular activity in a model of rat ventricular cardiomyocyte. Biomed. Res. Int., 2017, Vol. 2017, ID 6343821.
• Pásek M., Bébarová M., Christé G., Šimurdová M., Šimurda J.: Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study. Med. Biol. Eng. Comput., 2016, Vol. 54, p. 753-762.
• Hořaková Z., Matejovič P., Pásek M., Hošek J., Šimurdová M., Šimurda J., Bébarová M.: Effect of ethanol and acetaldehyde at clinically relevant concentrations on atrial inward rectifier potassium current IK1: separate and combined effect. J. Physiol. Pharmacol., 2016, Vol. 67, p. 339-351.
• Bébarová M., Matejovič P., Pásek M., Hořáková Z., Hošek J., Šimurdová M., Šimurda J.: Effect of ethanol at clinically relevant concentrations on atrial inward rectifier potassium current sensitive to acetylcholine. Naunyn Schmiedebergs Arch. Pharmacol., 2016, Vol. 389, p. 1049-1058.
• Bébarová M., Matejovič P., Pásek M., Šimurdová M., Šimurda J.: Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes. J. Physiol. Pharmacol., 2014, Vol. 65, p. 497-509.
• Pásek M., Šimurda J., Orchard C.H.: Effect of Ca2+ efflux pathway distribution and exogenous Ca2+ buffers on intracellular Ca2+ dynamics in the rat ventricular myocyte: a simulation study. Biomed. Res. Int., 2014, Vol. 2014, ID 920208.
• Hrabcová D., Pásek M., Šimurda J., Christé G.: Effect of ion concentration changes in the limited extracellular spaces on sarcolemmal ion transport and Ca2+ turnover in a model of human ventricular cardiomyocyte. Int. J. Mol. Sci., 2013, Vol. 14, p. 24271-24292.
• Pásek M., Šimurda, J., Orchard, C.H.: Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte. Eur. Biophys. J., 2012 , Vol. 41, p. 491-503.
• Kilianová A., Bébarová M., Beránková K., Opatřilová R., Pásek M., Bartošová L.: Effect of newly synthesized compounds 44Bu and 444 on QRS -complex width and fast sodium current: differences between isomers. Acta Vet. Brno, 2010, Vol. 79, p. 41-49.
• Bébarová M., Matejovič P., Pásek M., Ohlídalová D., Jansová D., Šimurdová M., Šimurda J.: Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes. Acta Physiol. (Oxf.), 2010, Vol. 200, p. 301-314.
• Orchard C.H., Pásek M., Brette F.: The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches (review). Exp. Physiol., 2009, Vol. 94, p. 509-519.
• Bébarová M., Matejovič P., Pásek M., Jansová D., Šimurdová M., Nováková M., Šimurda J.: Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. Naunyn-Schmied. Arch. Pharmacol., 2009, Vol. 380, p.125-133.
• Pásek M., Šimurda J., Christé G., Orchard C. H.: Modelling the cardiac transverse-axial tubular system (review). Prog. Biophys. Mol. Biol., 2008, Vol. 96, p. 226-243.
• Pásek M., Brette F., Nelson A., Pearce C., Qaiser A., Christé G., Orchard C.H.: Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes. Prog. Biophys. Mol. Biol., 2008, Vol. 96, p. 244-257.
• Pásek M., Šimurda J., Orchard C.H., Christé G.: A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system. Prog. Biophys. Mol. Biol., 2008, Vol. 96, p. 258-280.
• Christé G., Chahine M., Chevalier P., Pásek M.: Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3. Prog. Biophys. Mol. Biol., 2008, Vol. 96, p. 281-293.
• Pásek M., Šimurda J., Christé G.: The functional role of cardiac T-tubules in a model of rat ventricular myocytes. Phil. Trans. R. Soc. A., 2006, Vol. 364, p. 1187-1206.
• Bébarová M., Matejovič P., Pásek M., Nováková M.: Effect of haloperidol on transient outward potassium current in rat ventricular myocytes. Eur. J. Pharm., 2006, Vol. 550, p. 15-23.
• Bébarová M., Matejovič P., Pásek M., Šimurdová M., Šimurda J.: Effect of ajmaline on transient outward current in rat ventricular myocytes. Gen. Physiol. Biophys., 2005, Vol. 24, p. 27-45.
• Bébarová M., Matejovič P., Pásek M., Šimurdová M., Šimurda J.: Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes. Gen. Physiol. Biophys., 2005, Vol. 24, p. 311-325.
• Pásek M., Šimurda J.: Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. Med. Biol. Eng. Comput., 2004, Vol. 42, p. 151-157.
• Pásek M., Christé G., Šimurda J.: A Quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system. Gen. Physiol. Biophys., 2003, Vol. 22, p. 355-368.
• Šimurda J., Šimurdová M., Pásek M., Bravený P.: Quantitative analysis of cardiac electrical restitution. Eur. Biophys. J., 2001, Vol. 30, p. 500-514.

22. 8. 2017