ZLBC0221p Biochemisty I - lecture

Faculty of Medicine
Spring 2008
Extent and Intensity
2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
doc. MUDr. Jaromír Sláma, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
Mgr. Jan Alán (seminar tutor)
RNDr. Hana Bochořáková (assistant)
Mgr. Martin Klepárník, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Lenka Nerudová (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Vladimír Palyza, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Wed 7:30–9:20 P51 Posluchárna V. Čermáka
Prerequisites (in Czech)
ZLLC011s Med.Chem.- sem.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Syllabus
  • Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Enzyme cofactors, review of structures and functions. Mechanisms of enzyme action. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity, the conditions used. Factors affecting catalytic activity of enzymes, types of enzyme inhibition. Metabolism: basic concepts and design. Biological oxidations, generation of high-energy compounds. Saccharide metabolism: the glycolytic pathway and aerobic decarboxylation of pyruvate. Gluconeogenesis. Glycogen biosynthesis and breakdown. The pentose phosphate pathway. The glucuronate pathway. Interconversions of monosaccharides and of their derivatives. Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle. Metabolic breakdown of individual amino acids. Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols. Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids. Interrelationships among the major pathways involved in energy metabolism. The citric acid cycle. Synthesis of haem. Mitochondria. Oxidative phosphorylation - mitochondrial electron transport chain, synthesis of ATP. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Chromatin, DNA replication. DNA transcription. Regulation of gene expression. Protein synthesis and post-translational processing.
Literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny (I. a II. díl). 1st ed. Praha: Karolinum, 2004, 561 pp. ISBN 80-246-0851-0. info
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on completion of the course: zkoušku lze konat až po vykonání zkoušky z Lékařské chemie
The course is taught annually.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Lékařské chemie
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020.
  • Enrolment Statistics (Spring 2008, recent)
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