ZLBC0221p Biochemisty I - lecture

Faculty of Medicine
Spring 2012
Extent and Intensity
2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
PharmDr. Lenka Adámková, Ph.D. (assistant)
RNDr. Hana Bochořáková (assistant)
Ing. Martina Čarnecká, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
Mgr. Jana Kantorová (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Ing. Jitka Melounová, Ph.D. (assistant)
Lenka Nerudová (assistant)
Ing. Jana Simonová, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Vladimír Palyza, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Wed 7:30–9:20 B11/114
  • Timetable of Seminar Groups:
ZLBC0221p/VLA: Wed 13:00–14:50 B11/234
Prerequisites (in Czech)
ZLLC011s Med.Chem.- sem. && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. The graduate is acquainted with properties and function of enzymes, is oriented in catabolic and anabolic pathways of metabolism of saccharides, lipids and proteins and their consequences.Understands the principles of cell bioenegetics.Become familiar with the funcion of cell membranes, principle of cell compartmentation and membrane transport.Has knowledge on proteosynthesis including processes replication,transcription, translation and posttranslantion modifications.Understands the relation between the structure and function of proteins. Is acquinted with function of hemoglobine in oxygen transport.Molecular bases of some diseases are introduced. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.
Syllabus
  • Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Enzyme cofactors, review of structures and functions. Mechanisms of enzyme action. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity, the conditions used. Factors affecting catalytic activity of enzymes, types of enzyme inhibition. Metabolism: basic concepts and design. Biological oxidations, generation of high-energy compounds. Saccharide metabolism: the glycolytic pathway and aerobic decarboxylation of pyruvate. Gluconeogenesis. Glycogen biosynthesis and breakdown. The pentose phosphate pathway. The glucuronate pathway. Interconversions of monosaccharides and of their derivatives. Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle. Metabolic breakdown of individual amino acids. Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols. Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids. Interrelationships among the major pathways involved in energy metabolism. The citric acid cycle. Synthesis of haem. Mitochondria. Oxidative phosphorylation - mitochondrial electron transport chain, synthesis of ATP. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Chromatin, DNA replication. DNA transcription. Regulation of gene expression. Protein synthesis and post-translational processing.
Literature
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny, I. a II. díl. Druhé vydání. Praha: Karolinum, 2009, 546 pp. ISBN 978-80-246-1414-4. info
    recommended literature
  • HARVEY, Richard A. and Denise R. FERRIER. Biochemistry. 5th edition. Baltimore: Wolters Kluver, Lippincott Williams & Wilkins, 2011. International Edition. ISBN 978-1-60913-998-8. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars VSBC021s
Assessment methods
Student must have course-unit credit of seminar in the day of exam. Examination has writen and oral part. Writen part has 25 questions and is solved on computers in computer room of Department of Biochemistry. The second part is oral.Examination questions and other instructions you will find in the section Study materials of the course.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on completion of the course: zkoušku lze konat až po vykonání zkoušky z Lékařské chemie
The course is taught annually.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Lékařské chemie
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020.
  • Enrolment Statistics (Spring 2012, recent)
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