BLKIM051p Clinical imunology-lecture

Faculty of Medicine
autumn 2019
Extent and Intensity
0/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MUDr. Jiří Litzman, CSc. (lecturer)
prof. MUDr. Jindřich Lokaj, CSc. (lecturer)
Mgr. Marcela Vlková, Ph.D. (lecturer)
Miroslava Bučková (assistant)
Guaranteed by
Mgr. Marcela Vlková, Ph.D.
Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Contact Person: prof. MUDr. Jiří Litzman, CSc.
Supplier department: Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Timetable
Mon 6. 1. 12:00–14:30 ÚKIA N04303, Tue 7. 1. 12:00–14:30 ÚKIA N04303, Wed 8. 1. 12:00–14:30 ÚKIA N04303, Thu 9. 1. 12:00–14:30 ÚKIA N04303, Fri 10. 1. 12:00–14:30 ÚKIA N04303
Prerequisites (in Czech)
BLKFY0222p Physiology II-lec.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course will give a basic information about structural and functional characteristics of the immune system, about physiology and pathology of immunity, immunological treatment and prophylaxis and about possibilities of laboratory immunological approaches to asses the immune status of a patient. After finishing the course the students will understand the mechanisms of the immune response in physiology. The obtainmed knowledge will enable them to understand the immune system disturbances leading to immunopathological diseases, such as possibilities of immunological laboratory diagnostic and make raeasoned decisions about the use of immunological test in a concrete situation.
Learning outcomes
After completion of the course the students are able to process, discuss and evaluate the given immunological topics.
Syllabus
  • .Physiology and pathology of the immune system. Immunological concept of “own”, “foreign”, “dangerous”.
  • Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation.
  • B lymphocytes and immunoglobulins. Genetic basis of immunoglobulin heterogeneity. Biological properties of antibodies. Monoclonal antibodies as diagnostic and therapeutic tools.
  • T-lymphocytes, their development and effector functions. Polarisation of T-lymphocytes (T1, T2, Th17). Cytotoxicity. Cytokines.
  • Major histocompatibility complex: structure, function. Activation of T and B cells by antigen. Interactions between antigen-presenting cells and T- and B-lymphocytes. Regulation of the immune reaction.
  • Active and passive immunisation
  • Primary and secondary immunodeficiency disorders. HIV disease.
  • Active and passive immunisation. Immunoglobulin therapy. Immunostimulation.
  • Autoimmunity and disease. Immunological tolerance. Autoantibodies and their laboratory detection. Clinically significant organ specific and organ non-specific autoantibodies.
  • Hypersensitivity reactions - anaphylactic, cytotoxic, immune complex, T-cell-mediated.
  • Clinical allergology. Allergic skin and exposition tests. Prevention and treatment of allergic diseases.
  • Immunology of organ and bone marrow transplantation. Graft vs. host reaction
  • Tumor immunology. Tumor antigens. Immune response to tumors. Immunodiagnosis of tumors. Immune-related malignancies.
Literature
    recommended literature
  • HOŘEJŠÍ, Václav, Jiřina BARTŮŇKOVÁ, Tomáš BRDIČKA and Radek ŠPÍŠEK. Základy imunologie. 6., aktualizované vydání. V Praze: Stanislav Juhaňák - Triton, 2017, 297 stran. ISBN 9788075532503. info
  • ABBAS, Abul K., Andrew H. LICHTMAN and Shiv PILLAI. Basic immunology : functions and disorders of the immune system. Fifth edition. St. Louis: Elsevier, 2016, x, 335. ISBN 9780323390828. info
Teaching methods
The subject is given in a form of lectures.
Assessment methods
Presence on lectures is required. The subject is finihed by an oral exam. The exam consists of two questions - one is from teoretical immunology and immunopathology, the second one from the immunological laboratory methods. A credit from the subjects BLIM0P 11c is required for the exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: 15.
The course is also listed under the following terms Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018.
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