FaF:FDTTE_FAF Pharmaceutical Technology - Course Information

FDTTE_FAF Pharmaceutical Technology

Extent and Intensity

1/1/0. 30 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
doc. PharmDr. Ruta Masteiková, CSc. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)

Guaranteed by

prof. PharmDr. Mgr. David Vetchý, Ph.D.
Faculty of Pharmacy

Prerequisites

FAKULTA(FaF)
Exam within DSP study

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• Pharmaceutical Technology (programme FaF, D-FT) (2)
• Pharmaceutical Technology (programme FaF, D-FTA)

Course objectives

The content of the subject is the issue of technological procedures leading to the design of a stable pharmaceutical form, which has the desired release of the drug and it is possible to manufacture it industrially, methods of their evaluation by the methods described in scientific and professional publications with emphasis on the knowledge of science and research contained in world databases and increasing the student's ability to process the knowledge gained from the field of pharmaceutical technology principles into research texts.

Learning outcomes

Comprehensive knowledge in the field of pharmaceutical technology, above-standard knowledge in issues related to the field of student research.

Syllabus

• 1. Parenteral dosage forms
  2. Mucoadhesion and its application in drug technology, mucoadhesive agents.
  3. Interactive powder mixtures (preparation methods, physico-chemical characteristics affecting the properties of the interactive powder mixture)
  4. Pellets (physical-chemical properties, preparation, evaluation)
  5. Plant extracts (physical-chemical properties, preparation, evaluation)
  6. Controlled release and its characteristics (pulse, delayed, prolonged)
  7. Good Manufacturing Practice (Basic Principles and Legislation)
  8. Validation of the production of medicinal products (critical steps, statistical methods, basic documents)
  9. Controlled release drug matrix tablets
  10. Lipophilic auxiliaries and their use in matrix systems technology
  11. Evaluation of solid dosage forms
  12. Powders as a pharmaceutical form and intermediate for preparation of granules, tablets and capsules preparation and evaluation
  13. Solid state drug, polymorphs, amorphous phases, salts and co-crystals
  14. Assessment of the release of the drug from the pharmaceutical form of the pharmacopoeial and non-pharmacopoeial methods
  15. Drug microforms, technology for their preparation and use in pharmacotherapy.
  16. Microparticles. Possibilities to influence the quality parameters of microparticles prepared by external ion gelation.
  17. The use of lactic acid and glycolic acid copolymer in pharmaceutical technology (its properties, PLGA microparticles, PLGA implants)
  18. Transdermal dosage forms and their evaluation.
  19. Use of swelling cellulose derivatives in drug mold technology
  20. Texture analysis in the evaluation of solid dosage forms
  21. Granulates and granulation technologies
  22. Orodispersible dosage forms
  23. Stability testing of the medical forms
  24. Capsules method of preparation, manufacture, types and uses
  25. Pharmacopoeial evaluation of flow properties
  26. Pharmacopoeial evaluation of the tablets
  27. Distribution of essential excipients for tablet production
  28. Matrix controlled release systems
  29. Tablets (preparation, evaluation)
  30. Biorelevant dissolution method (media, pH, sampling times, dissolution devices)
  31. Statistical methods used to assess the content uniformity of dosage forms
  32. Delayed and pulsed-release dosage forms (preparation, evaluation)
  33. Coated preparations (coating materials and methods of coating of oral medicinal products)
  34. Sterile medicinal products (preparation, evaluation, use)
  35. Analytical evaluation of polymer materials (overview of methods and their utilization, gel chromatography)
  36. Oral dosage forms (distribution according to pharmacopoeia, preparation, excipients ...)
  37. IN VITRO IN VIVO correlation in drug development.
  38. Kinetic models for releasing drug substance from a pharmaceutical form
  39. Possibilities of preparation of a specific solid phase to influence the rate of dissolution and bioavailability
  40. Rheological measurements in the evaluation of drug forms
  41. Cellulose and its derivatives in the technology of pharmaceutical forms and medical devices.
  42. Natural polymers in the technology of pharmaceutical forms and medical devices.
  43. Hydrophilic gels - technology of preparation and production, auxiliaries.
  44. Topical semi-solid preparations - distribution, technological aspects, auxiliaries.
  45. Modern medical devices (wound healing) in wound therapy - characteristics, requirements, overview.
  46. Methods of preparation / production of polymer films.
  47. Excipients for the preparation / production of polymer films.
  48. Application of polymer films in pharmacy (pharmaceutical forms), health care and other fields.
  49. Methods of evaluation of wound dressing quality.
  50. Prolonged-release vaginal drugs (vaginal rings, vaginal inserts, mucoadhesive dosage forms)
  

Literature

recommended literature
• Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info

Teaching methods

Self-study, consultations

Assessment methods

Oral examination

Language of instruction

Czech

Further comments (probably available only in Czech)

The course can also be completed outside the examination period.
The course is taught each semester.

Teacher's information

Teaching is by way of consultation.
Current literature will be communicated to the student by the guarantor upon request.

• Enrolment Statistics (Autumn 2021, recent)
  
• Permalink: https://is.muni.cz/course/pharm/autumn2021/FDTTE_FAF