FDTTE_FAF Pharmaceutical Technology

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
1/1/0. 30 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
doc. PharmDr. Ruta Masteiková, CSc. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Faculty of Pharmacy
Prerequisites
FAKULTA(FaF)
Exam within DSP study
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The content of the subject is the issue of technological procedures leading to the design of a stable pharmaceutical form, which has the desired release of the drug and it is possible to manufacture it industrially, methods of their evaluation by the methods described in scientific and professional publications with emphasis on the knowledge of science and research contained in world databases and increasing the student's ability to process the knowledge gained from the field of pharmaceutical technology principles into research texts.
Learning outcomes
Comprehensive knowledge in the field of pharmaceutical technology, above-standard knowledge in issues related to the field of student research.
Syllabus
  • 1. Parenteral dosage forms
    2. Mucoadhesion and its application in drug technology, mucoadhesive agents.
    3. Interactive powder mixtures (preparation methods, physico-chemical characteristics affecting the properties of the interactive powder mixture)
    4. Pellets (physical-chemical properties, preparation, evaluation)
    5. Plant extracts (physical-chemical properties, preparation, evaluation)
    6. Controlled release and its characteristics (pulse, delayed, prolonged)
    7. Good Manufacturing Practice (Basic Principles and Legislation)
    8. Validation of the production of medicinal products (critical steps, statistical methods, basic documents)
    9. Controlled release drug matrix tablets
    10. Lipophilic auxiliaries and their use in matrix systems technology
    11. Evaluation of solid dosage forms
    12. Powders as a pharmaceutical form and intermediate for preparation of granules, tablets and capsules preparation and evaluation
    13. Solid state drug, polymorphs, amorphous phases, salts and co-crystals
    14. Assessment of the release of the drug from the pharmaceutical form of the pharmacopoeial and non-pharmacopoeial methods
    15. Drug microforms, technology for their preparation and use in pharmacotherapy.
    16. Microparticles. Possibilities to influence the quality parameters of microparticles prepared by external ion gelation.
    17. The use of lactic acid and glycolic acid copolymer in pharmaceutical technology (its properties, PLGA microparticles, PLGA implants)
    18. Transdermal dosage forms and their evaluation.
    19. Use of swelling cellulose derivatives in drug mold technology
    20. Texture analysis in the evaluation of solid dosage forms
    21. Granulates and granulation technologies
    22. Orodispersible dosage forms
    23. Stability testing of the medical forms
    24. Capsules method of preparation, manufacture, types and uses
    25. Pharmacopoeial evaluation of flow properties
    26. Pharmacopoeial evaluation of the tablets
    27. Distribution of essential excipients for tablet production
    28. Matrix controlled release systems
    29. Tablets (preparation, evaluation)
    30. Biorelevant dissolution method (media, pH, sampling times, dissolution devices)
    31. Statistical methods used to assess the content uniformity of dosage forms
    32. Delayed and pulsed-release dosage forms (preparation, evaluation)
    33. Coated preparations (coating materials and methods of coating of oral medicinal products)
    34. Sterile medicinal products (preparation, evaluation, use)
    35. Analytical evaluation of polymer materials (overview of methods and their utilization, gel chromatography)
    36. Oral dosage forms (distribution according to pharmacopoeia, preparation, excipients ...)
    37. IN VITRO IN VIVO correlation in drug development.
    38. Kinetic models for releasing drug substance from a pharmaceutical form
    39. Possibilities of preparation of a specific solid phase to influence the rate of dissolution and bioavailability
    40. Rheological measurements in the evaluation of drug forms
    41. Cellulose and its derivatives in the technology of pharmaceutical forms and medical devices.
    42. Natural polymers in the technology of pharmaceutical forms and medical devices.
    43. Hydrophilic gels - technology of preparation and production, auxiliaries.
    44. Topical semi-solid preparations - distribution, technological aspects, auxiliaries.
    45. Modern medical devices (wound healing) in wound therapy - characteristics, requirements, overview.
    46. Methods of preparation / production of polymer films.
    47. Excipients for the preparation / production of polymer films.
    48. Application of polymer films in pharmacy (pharmaceutical forms), health care and other fields.
    49. Methods of evaluation of wound dressing quality.
    50. Prolonged-release vaginal drugs (vaginal rings, vaginal inserts, mucoadhesive dosage forms)
Literature
    recommended literature
  • Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info
Teaching methods
Self-study, consultations
Assessment methods
Oral examination
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
Teaching is by way of consultation.
Current literature will be communicated to the student by the guarantor upon request.
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Spring 2024, Autumn 2024, Spring 2025.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/FDTTE_FAF