FaF:F1ME1_16 Molecular Biology - Course Information
F1ME1_16 Molecular Biology
Faculty of PharmacyAutumn 2024
- Extent and Intensity
- 2/0/0. 3 credit(s). Type of Completion: zk (examination).
- Teacher(s)
- Mgr. Marie Brázdová, Ph.D. (lecturer)
Mgr. Daniel Renčiuk, Ph.D. (lecturer)
PharmDr. Zuzana Soldánová (lecturer)
Mgr. Denis Šubert (lecturer)
PharmDr. Jakub Treml, Ph.D. (lecturer)
Mgr. Bc. Daniela Nykodýmová (assistant) - Guaranteed by
- Mgr. Marie Brázdová, Ph.D.
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Supplier department: Department of Molecular Pharmacy – Departments – Faculty of Pharmacy - Timetable
- Mon 8:00–9:40 45-135
- Prerequisites
- FAKULTA ( FaF ) || OBOR ( MUSFaF )
The knowledge of subject in range of lectures. - Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Pharmacy (programme FaF, M-FARM)
- Cosmetic Products (programme FaF, B-KOSM)
- Multidisciplinary studies at Faculty of Pharmacy (programme CST, KOS)
- Vzdělávání v jednotlivých předmětech (programme FaF, C-CV)
- Course objectives
- The aim of this subject is to provide students with basic information from molecular biology. The ground of lectures is focused on structure of proteins and nucleic acids and functions and relationships of these informational macromolecules in transition of genetic information. Students will familiarise with structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression. The molecular mechanisms of mutagenesis, recombination and transposition, reparation mechanisms and molecular basis of carcinogenesis are explained. The fundament of molecular evolution and theory of life origin on Earth are illustrated. Part of the lectures is focused on molecular biology methods and on applications of molecular biology principles in microbiology, pharmacology, human genetics, epidemiology and epizootology. Student requirements - achieving at least 60% of points from the written test
- Learning outcomes
- Basic knowledge of molecular biology forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics, Structure and evolution of genomes. After completing the course, the student will be able to: - identify and summarize important features on the structure of proteins and nucleic acids and the functions and relationships of information macromolecules in the transmission of genetic information; - describe the structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression; - describe the molecular mechanisms of mutagenesis, recombination and transposition, repair mechanisms and the molecular nature of carcinogenesis;
- Syllabus
- 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
5) Regulation of gene expression, molecular signalling.
6) RNA interference
7) Replication, expression of bacterial and animal virus's genes.
8) Mutagenesis, spontaneous and induced mutation and reversion.
9) Molecular basis of recombination, recombinantion in genetics.
10) Transposons, mechanisms of transposition, retroelements, retroviruses.
11) Reparation and excision mechanisms.
12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
13) Cell cycle and apoptosis
- 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
- Literature
- required literature
- D. Peter Snustad Michael J. Simmons. Genetika. Brno, 2017. ISBN 9788021086135. info
- recommended literature
- ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. B, 2002. info
- not specified
- RUSSELL, P.J. iGenetics, A molecular Approach. Pearson, Benjamin Cummings. New York, U.S.A., 2006. info
- WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Be, 2004. info
- ROSYPAL, S. et al. Terminologie molekulární biologie. Vydavatel prof. RNDr. Stanislav Rosypal, DrSc.,, 2001. info
- Teaching methods
- lectures, videos
- Assessment methods
- Written exam, 30 questions, mostly supplemented, evaluation of 60 points, to successfully complete the need to master 60%,
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course can also be completed outside the examination period.
- Teacher's information
- - rating from written test at least 60%
- Enrolment Statistics (recent)
- Permalink: https://is.muni.cz/course/pharm/autumn2024/F1ME1_16