Bi1152en Developmental Defects & Their Causes

Faculty of Science
Autumn 2024
Extent and Intensity
2/0/0. 2 credit(s) (plus 2 credits for an exam). Type of Completion: zk (examination).
Teacher(s)
Mgr. Jakub Harnoš, Ph.D. (lecturer)
Guaranteed by
Mgr. Jakub Harnoš, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: Mgr. Jakub Harnoš, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
This course aims to explore developmental defects from historical, contemporary, and methodological perspectives, covering prenatal and postnatal periods. It delves into key signaling pathways and their role in understanding developmental anomalies, along with strategies for prevention and mitigation. Additionally, this course serves as a supportive resource for Master students preparing for their State Exams in Developmental Biology.
Learning outcomes
Upon completion, students will understand the mechanisms of key signaling pathways involved in developmental defects. They will develop proficiency in analyzing these pathways' implications through case studies and experimental models, thereby enhancing their comprehension of developmental biology.
Syllabus
  • 1. Definition, history, and current status of developmental defects
  • 2. Prenatal and postnatal period of development
  • 3. Wnt signaling pathways & case reports (humans + animal models)
  • 4. Notch signaling pathway & case reports (humans + animal models)
  • 5. Receptor tyrosine kinases I & case reports (humans + animal models)
  • 6. Receptor tyrosine kinases II & case reports (humans + animal models)
  • 7. TGFβ signaling & case reports (humans + animal models)
  • 8. Hedgehog signaling & case reports (humans + animal models)
  • 9. Hippo signaling & case reports (humans + animal models)
  • 10. Eph/Ephrin signaling & case reports (humans + animal models)
  • 11. Small Rho GTPases & case reports (humans + animal models)
  • 12. Prevention and mitigation for developmental defects
Teaching methods
Teaching methods will focus on imparting theoretical knowledge of the studied phenomena. The course will be delivered through in-person lectures as well as online sessions.
Assessment methods
Evaluation will be based on student performance during a final oral exam.
Language of instruction
English
Further Comments
The course is taught annually.
The course is taught: every week.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2024/Bi1152en