C7018 Biochemistry basics - seminar

Faculty of Science
Autumn 2024
Extent and Intensity
0/1/0. 1 credit(s) (fasci plus compl plus > 4). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
Mgr. Lukáš Faltinek (seminar tutor)
prof. Mgr. Tomáš Kašparovský, Ph.D. (seminar tutor)
Guaranteed by
prof. Mgr. Tomáš Kašparovský, Ph.D.
Department of Biochemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Biochemistry – Chemistry Section – Faculty of Science
Timetable of Seminar Groups
C7018/01: Tue 12:00–12:50 45-221, L. Faltinek
C7018/02: Tue 13:00–13:50 45-221, L. Faltinek
C7018/03: Tue 14:00–14:50 45-221, L. Faltinek
Prerequisites
NOW( C7017 Biochem. basics )
Knowledge of the basics of chemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The goal is to gain basic knowledge of biochemical processes in the human body necessary for the study of related specialized subjects. The subject extends and deepens the knowledge acquired during high school chemistry studies.
Learning outcomes
- At the end of this course the students should theoretically understand the basic knowledge about chemical principles of metabolism of saccharides and lipids, cellular bioenergetics, structure and function of proteins and enzyme catalysis.
Syllabus
  • 01. Introduction. Composition of living matter, hierarchy of structures. Amino acids, peptides, proteins: essential amino acids, isoelectric point, peptide bonding, peptides, structure and properties of proteins, simple proteins, complex proteins, scleroproteins, spheroproteins. Proteins of the immune system.
  • 02. Carbohydrates: monosaccharides, derivatives of monosaccharides, oxidation and reduction of carbohydrates, disaccharides, homopolysaccharides, heteropolysaccharides. Distribution, structure and function in organisms. Glycoproteins and proteoglycans. Practical aspects.
  • 03. Fatty acids, lipids, phospholipids, glycolipids, isoprenoids, steroids, lipoproteins. Structure and significance of biomembranes
  • 04. Nucleosides, nucleotides, nucleic acids and their functions, replication, DNA damage, transcription, translation. PCR.
  • 05. Enzymes, their structure and distribution. Mechanism of action, types of inhibition. Rate of enzyme reactions, activity, conditions. Vitamins. Transmission of nervous excitement, neurotransmitters.
  • 06. General features of the transformation of substances in living systems. Catabolism and anabolism, macroergic compounds. Carbohydrate metabolism, glycolysis, anaerobic and aerobic conditions, gluconeogenesis, Cori cycle.
  • 07. Krebs cycle, anaplerotic pathways. Protein and amino acid metabolism: transamination, deamination, decarboxylation. Urea cycle, ketone bodies.
  • 08. Lipid metabolism: lipases, β-oxidation of fatty acids, fatty acid biosynthesis, ketone body formation. Respiratory chain: localization, proton motive force, ATP formation (oxidative phosphorylation). Thermogenesis.
  • 09. Muscle biochemistry, muscle fiber, muscle protein, muscle contraction, muscle energy, smooth muscle, smooth muscle contraction, myorelaxants. Hemoglobin, hemoglobin breakdown. Bile dyes. Conversion and detoxification of foreign substances, oxidation and reduction reactions, conjugation reactions.
Literature
  • DOSTÁL, Jiří, Hana PAULOVÁ, Jiří SLANINA and Eva TÁBORSKÁ. Biochemie pro posluchače bakalářských oborů. 1. dotisk 1. vyd. Brno: Masarykova univerzita, 2012, 158 pp. ISBN 978-80-210-5020-4. info
  • MURRAY, Robert K. Harperova biochemie. Vyd. v ČR 4., V H & H 3. Jinočany: H & H, 2002, ix, 872. ISBN 8073190133. info
  • BAYNES, John W. and Marek H. DOMINICZAK. Medical biochemistry. 2nd ed. Philadelphia, Pa.: Elsevier Mosby, 2005, xii, 693. ISBN 0723433410. info
  • VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, xiv, 1325. ISBN 8085605449. info
Teaching methods
Seminar: Class discussion on the problematics, exercises.
Assessment methods
Attendance at the seminar, 2 written tests (condition of fulfillment is success of min. 60 %).
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Teacher's information

The study material is in accordance with Act No. 121/2000 Coll. The Copyright Act, as amended, is considered to be the copyrighted work for which Masaryk's property rights are exercised. Please note that any distribution, takeover or further disclosure of its content is prohibited without the consent of MU.

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