PřF:Bi6930 Immunotoxicology - Course Information
Bi6930 Immunotoxicology
Faculty of ScienceSpring 2012
- Extent and Intensity
- 2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
- Teacher(s)
- prof. RNDr. Luděk Bláha, Ph.D. (lecturer)
- Guaranteed by
- prof. RNDr. Ivan Holoubek, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Luděk Bláha, Ph.D.
Supplier department: RECETOX – Faculty of Science - Timetable
- Mon 13:00–14:50 409-stara KAM1
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- General Biology (programme PřF, M-BI, specialization Ekotoxikology)
- General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
- Special Biology (programme PřF, N-EXB)
- Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)
- Course objectives
- At the end of the course, students will be able to:
- understand immune system as the organ sensitive to external factors including toxic chemicals.
- describe principles of immunotoxicology, i.e. research branch studying effects of stressors (mainly chemical compounds) on immune system and the importance of immune system changes for organism health.
- describe and discuss functions of the immune system, its components, communication with respect to toxic effects
- design and use experimental methods in immunotoxicology as well as interpret and analyze the results of the tiered tsting approach
- describe major laboratory methods in immunotoxicology,
- classify toxicants (drugs, pollutants, etc.), and describe ecological immunotoxicology (invertebrates, fish, amphibians). - Syllabus
- 1. Immunotoxicology. Introduction, history, aims and scopes, human immunotoxicology, ecological immunotoxicology. 2. Immune system. Components of immune system, function, communication, immune system as a target of xenobiotics. Immune system as a part of an organism - interactions, controls, homeostasis, (xeno-)estrogens. 3. Experimental design in immunotoxicology. Exposure, response. "Tier I" and "Tier II" methods. Animal models in immunotoxicology, batteries of immunotoxicology tests. 4. Laboratory methods in immunotoxicology. Assays of immunocompetence, macrophage function assays, host resistance, antitumor immunity, hypersensitivity, autoimmunity. 5. Special immunotoxicology 1 - introduction. Factors affecting immune system (climate, geography, biorhythms, stress, social habits, chemicals, irradiation and other physico-chemical factors). 6. Special immunotoxicology 2 - immunotoxicology of drugs (antibiotics, important pharamceuticals, immunosuppressives a immunomodulators, antitumor therapy). 7. Special immunotoxicology 3 - immunotoxicology of pollutants (metals, pesticides, industrial chemicals - PCBs, PAHs, PCDD(F)s, other organic pollutants, azbestosis, silikosis). 8. Ecological immunotoxicology. Animal immune system and interactions with xenobiotics. Invertebrates, fish, amphibians, birds, mammals. Markers of immune system alterations, ecological consequences. Case studies. 9. Risk assessment. Immunotoxicology as a branch of general toxicology, hazard identification, uncertainities.
- Literature
- Immunotoxicology and immunopharmacology. Edited by Jack H. Dean. 2nd ed. New York: Raven Press, 1994, xxi, 761 s. ISBN 0-7817-0219-4. info
- Wagner, V., Wagnerová, M. Ekoimunologie, Avicenum, 1988, Praha
- Ferenčík, M. Immunochémia, Alfa, 1989, Bratislava
- Teaching methods
- lectures (weekly), e-learning support incorporated in the IS.MUNI.CZ system
- Assessment methods
- final written test and oral examination
- Language of instruction
- Czech
- Further Comments
- Study Materials
The course is taught annually. - Teacher's information
- http://www.recetox.muni.cz/studium
- Enrolment Statistics (Spring 2012, recent)
- Permalink: https://is.muni.cz/course/sci/spring2012/Bi6930