C7505 Bioorganic chemistry

Faculty of Science
Spring 2013
Extent and Intensity
2/0/0. 2 credit(s) (plus 2 credits for an exam). Recommended Type of Completion: zk (examination). Other types of completion: z (credit).
Teacher(s)
doc. Ing. Pavel Bobáľ, CSc. (lecturer)
prof. Ing. Zdeněk Wimmer, DrSc. (lecturer)
Guaranteed by
prof. RNDr. Milan Potáček, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Timetable
Fri 11:00–14:50 A08/309
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 11 fields of study the course is directly associated with, display
Course objectives
The lecture is focused on students interested in studies in synthetic chemistry and in biochemistry. The objective of the lectures consists in explaining the principles of application of enzymes in chemistry and biochemistry to the students, as well as showing them advantages of sustainable raw material resources in organic synthesis, with a special focus on pharmaceutical and food industry. Large scale industry production of selected products will also be mentioned. In the end of the course, students will be able to use the knowledge on the basis of chemical and biochemical processes applicable in practice, in which selected types of sustainable raw material (mono-, di-, oligo- and polysaccharides, oils, fatty acids and lignin) may be used. In the end of the course, students will be able to use the knowledge both in practice and in future studies, will be able to deduce and to apply the rules to the novel and unknown chemical and biochemical processes, and will be able to evaluate correctly reactions performed in laboratory and industrial scale.
Syllabus
  • • Enzymes – definition, structure and properties. • Reactions catalyzed by enzymes, basic principles, selectivity. • Biocatalysis – application in organic synthesis: hydrolytic reactions. • Biocatalysis – application in organic synthesis: addition and elimination reactions, oxidation and reduction reactions, reactions with functional group transfer. • Special techniques – enzymes in organic solvents, immobilization of enzymes. • Application of biocatalysis in pharmaceutical industry. • Biotechnology – fermentation technology in practice. • Sustainable energy resources, definition of the categories, definition of oils and saccharides, theory of sweet taste, sucrose and chemical transformations of sucrose. • Biochemical transformations of sucrose. • Glukose. • Fructose. • Selected polysaccharides: Cellulose, starch, glykogen and related compounds. • Fatty acids and their natural derivatives: synthetic applications (Part 1). • Fatty acids and their natural derivatives: synthetic applications (Part 2).
Literature
  • FABER, Kurt. Biotransformations in organic chemistry : a textbook. 5th rev. and corr. ed. Berlin: Springer-Verlag, 2004, xi, 454. ISBN 3540200975. info
  • Biochemistry. Edited by Jeremy M. Berg - John L. Tymoczko - Lubert Stryer. 5th ed. New York: W.H. Freeman and Company, 2002, xxxviii, 9. ISBN 0-7167-4684-0. info
  • Bioorganická chemie. Edited by Zdeněk Vodrážka - Jiří Krechl. 1. vyd. Praha: SNTL - Nakladatelství technické literatury, 1991, 480 s. ISBN 80-03-00547-7. info
  • PROKOP, Zbyněk, Tomáš MOZGA, Petr JEŘÁBEK, Yukari SATO, Yuji NAGATA, Y. SENDA, Dick JANSSEN and Jiří DAMBORSKÝ. The Use of Enzyme Catalysis In Bioorganic Synthesis. 2005. URL info
  • • Enzyme Catalysis in Organic Synthesis: A Comprehensive Handbook. Drauz K., Waldmann H. VCH 1995.
Teaching methods
Lectures connected with discussion within the lecture.
Assessment methods
Written test.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2014, Spring 2015.
  • Enrolment Statistics (Spring 2013, recent)
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