C9909 Elements of fine process chemistry

Faculty of Science
Spring 2025
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
RNDr. Petr Beňovský, Ph.D. (lecturer)
Guaranteed by
doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
Basic knowledge of organic chemistry, organic synthesis, physical chemistry
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
This lecture should provide much broader information about practical aspects of process chemistry that is very important in the real professional life in process chemistry companies.
Learning outcomes
After successful completion of the lecture (passing the exam) a student should be able to understand factors that apply on different scales of a chemical process. A student should be able to independently decide which reaction system is suitable for a purpose, should be able to distinguish among several options and select the best one. A student is trained to apply theoretical knowledge and understand its impact to the outcome of the chemical reaction.
Syllabus
  • Outline of the class; History of fine process chemistry, recent trends, future; Differences between laboratory and larger scale experiments; Scale-up/downscale considerations; Safety; Crystallization (solubility, metastable zone, nucleation, crystal growth, optical resolution, Viedma ripening, attrition enhanced deracemization, seeding, Ostwald ripening, new trends in crystallization); Polymorphism; Typical process operations (mixing, heat transfer, agglomeration, product isolation, distillation, drying, purification, work up, reactors); Continuous manufacturing, flow chemistry; Synthetic route selection; Analytical methods, Process Analytical Technology (PAT), Design of Experiments (DoE), Quality by Design (QbD); Environmental Aspects; Economy, Cost of Goods (CoG); Regulatory issues, patents. Copious example from recent literature about various topics within the whole lecture.
Literature
  • Neal Anderson, Practical Process Research & Development, Elsevier, 2nd Ed. 2012
Teaching methods
Lectures
Assessment methods
Final written test
Language of instruction
English
Further Comments
The course is taught once in two years.
The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2022, Spring 2023.
  • Enrolment Statistics (recent)
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