FI:VV072 Molecular biology - Course Information
VV072 Molecular biology for bioinformaticsFaculty of Informatics
- Extent and Intensity
- 2/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
- doc. RNDr. Irena Koutná, Ph.D. (lecturer)
Mgr. Pavel Šimara, Ph.D. (lecturer)
Mgr. Lenka Tesařová, Ph.D. (lecturer)
- Guaranteed by
- doc. RNDr. Petr Matula, Ph.D.
Department of Visual Computing - Faculty of Informatics
Contact Person: doc. RNDr. Irena Koutná, Ph.D.
Supplier department: Department of Visual Computing - Faculty of Informatics
- Wed 10:00–11:50 A318
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- there are 24 fields of study the course is directly associated with, display
- Course objectives
- The aim of this lecture is to provide the introduction into molecular biology and into general processes by which the cells express their genetic information. At the end of the course the student will be able to understand basic information about the genome structure and function, gene expression principles and the cell behaviour at the molecular level.
- 1. History of molecular biology. Nucleic acids and proteins (Structure and function of DNA, RNA and proteins; interaction of proteins with DNA) 2. Genome structure and genetic information (Structure of bacterial and eukaryotic genome, genome evolution, genetic code, transcription unit) 3. Genome replication, DNA repair and recombination (Replication of bacterial and eukaryotic genome, molecular basis of mutagenesis, DNA recombination and repair mechanisms) 4. Genome transcription (Transcription of bacterial and eukaryotic genome, post-transcriptional processing of RNA, mechanisms of RNA splicing) 5. Genome translation (Translation of bacterial and eukaryotic mRNA, the ribosome structure, post-translational processing) 6. Regulation of gene expression (Control of bacterial and eukaryotic genome expression, induction and repression, operon, transcription factors, posttranscriptional regulatory mechanisms) 7. Molecular mechanisms of signalling (Molecules involved in signalling pathways, receiving and processing of signals, communication between cells) 8. Molecular structure of eukaryotic cells (Molecular structure of the cell, transport of molecules within and outside the cell) 9. Cell cycle regulation (Molecular basis of cell cycle phases, regulation of cell growth and division) 10. Programmed cell death and molecular basis of acquired immunity (Immunoglobulins, BCR and TCR expression, development and activation of T- and B-cells) 11. Molecular basis of cancer (Basic characteristics of tumour cells, oncogenes, proto-oncogenes, tumour suppressors) 12. Methods of molecular biology and basic principles of gene engineering (Essential methods to study genome, transcriptome and proteome, genetic manipulations)
- recommended literature
- SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1. vyd. Brno: Masarykova univerzita, 2009. 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
- Teaching methods
- Lectures 12x120 min
- Assessment methods
- 1 written test divided into 3 parts according to the type of expected answer - a) yes/no b) multichoice c) text. 30 questions
- Language of instruction
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually.