EMEM0731p Embryology

Faculty of Medicine
autumn 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
PharmDr. Zuzana Holubcová, Ph.D. (lecturer)
Drahomíra Kyjovská (assistant)
MUDr. Eva Mecová (assistant)
Guaranteed by
doc. MVDr. Aleš Hampl, CSc.
Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 11:00–12:40 F01B1/126
Prerequisites (in Czech)
Povinná účast na přednášce externího přednášejícího v průběhu semestru.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The goal of the course is for students to have a thorough understanding of female germ cell biology and to be able to implement this knowledge into clinical practice.
Learning outcomes
Graduates of the course will have a comprehensive and thorough overview of the biology of female germ cells.
Syllabus
  • - Origin, characterization, migration and proliferation of primordial germ cells - - Mitosis and meiosis, homologous recombination, oocyte maturation, chromosomal segregation, disorders of gametogenesis (azoospermia, aneuploidy of eggs) - - Oogenesis and folliculogenesis (oocyte-follicular cell interaction, control of dormancy and activation of primordial follicles, follicle growth and selection, importance of atresia), experimental approaches in the management of folliculogenesis disorders - - Molecular mechanism of meiotic arrest (prophase I), oocyte maturation and MII arrest, - - Molecular mechanisms and disorders of ovulation, physiology and pathophysiology of the corpus luteum - - Morphology and ultrastructure of the oocyte, morphological abnormalities and their clinical significance, in vitro aging) - - Role of the cytoskeleton during oocyte development - - Oocyte polarity and role of maternal factors in somatic cell nuclear reprogramming - - Regulation of transcription and translation during oogenesis, oocyte metabolism - - Inheritance and prevention of mitochondrial diseases - - Influence of environmental factors on oocyte quality
Literature
    recommended literature
  • Coward K., Wells D.: Textbook of Clinical Embryology, 1st ed., Cambridge 2013.
  • Trounson A, Gosden R, Eichenlaub-Ritter: Biology and Pathology of the Oocyte. 2nd ed., Cambridge 2013. Gardner DK, Sakkas D, Seli E, Wells D: Human gametes and preimplantation Embryos. 1st ed. New York 2013.
  • In vitro fertilization. Edited by Kay Elder - Brian Dale. 2nd ed. New York: Cambridge University Press, 2000, xii, 310 p. ISBN 0521778638. info
Teaching methods
lecture
Assessment methods
oral exam
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms autumn 2023.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2024/EMEM0731p