CH2RC_3P2P Biochemistry

Faculty of Education
Autumn 2006
Extent and Intensity
0/0/0. 5 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Jiří Šibor, Ph.D. (lecturer)
Guaranteed by
Mgr. Jiří Šibor, Ph.D.
Department of Physics, Chemistry and Vocational Education – Faculty of Education
Contact Person: Helena Pelcová
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Structure of Living Matter. Composition and Organization of Cells. Classes of Biomolecules: Amino Acids and Proteins, Carbohydrates, Nucleic Acids, Lipids and Membranes. Metabolism. Energetics of Biochemical Reactions. Enzymes and Coenzymes. Metabolic Fate of Biomolecules. Metabolism of Amino Acids and Proteins. Metabolism of Nucleic Acids and Proteosynthesis. Metabolism of Saccharides and Lipids. Bioenergetic Metabolism. Integration of Metabolism, Regulation Principles. Membrane Transport. Special Biosynthetic Pathways.
Syllabus
  • The subject of biochemistry. Life. Organization of cells. Amino acids. Structural features and properties. Peptides. Structure and nomenclature. Analysis and synthesis. Important peptides. Proteins. Structure and properties. Conformation and its changes. Function of proteins - catalytic, structural, transport, signal, defense. Nucleic acids. Structure and metabolism of polynucleotides. Carbohydrates. General properties and reactions of monosaccharides. Di-, oligo- and polysaccharides. Lipids. Composition and properties, classification, function. Structure of biomembranes. General features of metabolism, anabolic and catabolic processes. Chemical reactions, equilibrium, energetics. Macroergic compounds. Enzymes. Conditions of enzymatic reactions. Enzyme kinetics. Organization of enzymes, regulation. Enzyme classification and nomenclature. Measurement of activities, units. Isolation of enzymes. Coenzymes, types, functions. Proteins catabolism. Digestion. General conversion of amino acids. Nitrogen metabolism. Amino acids metabolism, interconversion and catabolism. Degradation and synthesis of nucleic acids. Nucleotide metabolism, synthesis and degradation. Genetic information, its transfer and expression. Protein synthesis, regulatory mechanisms. Metabolism of saccharides. Degradation and biosynthesis of polysaccharides. Glycolysis. Reaction scheme, energetics, regulation. Resynthesis of glucose. Other conversions of saccharides. Hexose monophosphate pathway, pentose cycle. Metabolism of lipids. Degradation and biosynthesis of fats and phosphatides. Degradation and biosynthesis of fatty acids. Ketonic compounds. Tricarboxylic acids cycle. Reaction scheme, energetics. Metabolic relations, regulation. Biological oxidation. Types and role, examples. Energetics. Oxidative phosphorylation. The organization of respiratory chain. Mechanism of electron transport, generation and use of protonmotive force, ATP synthesis. Photosynthesis. Pigments, organization, electron transport. Carbon dioxide fixation. Microsomal electron transport, nitrogenase system. Oxygenation. Porphyrins. Heme biosynthesis and degradation. Isoprenoids. Biosynthesis. Terpenoids, carotenoids, vitamins, isoprenic quinones. Steroids, nomenclature, biosynthesis, conversions. Hormones, bile acids, vitamin D. Biosynthesis of aromatic compounds. Alkaloids, basic principles of their bisynthesis. Regulation of metabolism. Mutual relations in metabolism. Regulatory levels. Regulation of enzyme activity, metabolic pools. Compartmentation. Membrane gradients, solute transport. Types,energetics. Important translocase systems. Neurohumoral system. Mechanism of hormone action. Mineral metabolism, the role of ions in biochemical processes. Nerve excitation, muscle contraction.
Literature
  • ŠÍPAL, Zdeněk. Biochemie. 1. vyd. Praha: Státní pedagogické nakladatelství, 1992, 479 s. ISBN 8004217362. info
  • KARLSON, Peter. Základy biochemie. Translated by Jan Kocourek - Sylva Leblová. 3., přeprac. vyd. Praha: Academia, 1981, 501 s. info
Assessment methods (in Czech)
Typ výuky: přednáška. Ukončení: ústní zkouška
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on the extent and intensity of the course: 12 hodin.
The course is also listed under the following terms Autumn 2005, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017.
  • Enrolment Statistics (Autumn 2006, recent)
  • Permalink: https://is.muni.cz/course/ped/autumn2006/CH2RC_3P2P