FDMUa_FAF Mechanisms of Drug Release and their Statistical Evaluation

Faculty of Pharmacy
Autumn 2025
Extent and Intensity
2/0/0. 5 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
Guaranteed by
doc. Mgr. Jan Muselík, Ph.D.
Faculty of Pharmacy
Supplier department: Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Expanding the knowledge of the student focusing on in vitro and in vivo mechanisms of drug release and their statistical evaluation, obtained mainly from world databases containing knowledge from scientific publications especially of foreign research experts and institutions and increasing the ability of the student to process this knowledge into research texts focusing on the content of the study program.
Learning outcomes
After completing the course the student will: - have theoretical knowledge in the field of dissolution testing - be able to interpret the dissolution profile of a drug from a dosage form - theoretically and practically master the use of mathematical models to infer the kinetics and mechanism of drug release - estimate the effect of polymer blends on drug release - be able to make sophisticated comparisons of dissociation profiles
Syllabus
Dissolution testing of drug forms. Modeling and comparison of dissolution profiles. Mathematical comparison of dissolution profiles. The effect of polymer blends on the release profiles. A simple equation for description of solute release - Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. Design and evaluation of matrix-based controlled release tablet. Formulation study and drug release mechanism. Drug release evaluation.
Literature
    recommended literature
  • Advances and challenges in pharmaceutical technology : materials, process development and drug delivery strategies. Edited by Amit Kumar Nayak - Kunal Pal - Indranil Banerjee - Samarendra Maji - U. London: Academic Press, 2021, 1 online. ISBN 9780128203002. URL info
  • MUSELÍK, Jan; Jakub VYSLOUŽIL and Kateřina KUBOVÁ. Modern Instrumental Methods in Solid Dosage Form Analysis. 1st ed. Brno: Masarykova univerzita, 2021, 231 pp. ISBN 978-80-210-9723-0. info
  • ROWE, Philip. Essential statistics for the pharmaceutical sciences. Second edition. Chichester: Wiley, 2016, xx, 409. ISBN 9781118913390. info
  • VETCHÝ, David and Vladimír VETCHÝ. Klíč ke statistickému vyhodnocování farmaceutických studií. Vydání 1. Brno: Veterinární a farmaceutická univerzita, 2006, iii, 123. ISBN 8073055651. info
Teaching methods
consultation with the teacher
Assessment methods
Oral examination
Language of instruction
English
The course is also listed under the following terms Spring 2025, Spring 2026.
  • Enrolment Statistics (Autumn 2025, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2025/FDMUa_FAF