Bi5051 Pathogenesis of Viral Infections

Faculty of Science
Autumn 2023
Extent and Intensity
1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Daniel Růžek, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Daniel Růžek, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Prerequisites
The lectures are held for students of biological disciplines (General Biology, Molecular Biology and Genetics, Special Biology), eventually for others interested in virology.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 20 student(s).
Current registration and enrolment status: enrolled: 1/20, only registered: 0/20, only registered with preference (fields directly associated with the programme): 0/20
fields of study / plans the course is directly associated with
  • Special Biology (programme PřF, N-EXB, specialization Mikrobiologie a molekulární biotechnologie)
  • Virology (programme PřF, N-VIR)
Course objectives
The goal of this course is to provide a complete overview about the pathogenesis of viral infections, with special regard to the interaction of virus with host on molecular, cellular and organismal level. Special attention will be paid to emerging and re-emerging viral infections.
Learning outcomes
After completing the course, the student will be able to describe, explain and apply basic mechanisms of virus-host interactions at the molecular, cellular and organismal level, will know basic metabolic and morphological changes occurring in virus infected cells and tissues, will be able to describe defense mechanisms of the host organism against viral infection and will know basic mechanism of tumor transformation induced by viruses. The information presented within this course will be useful further scientific career of the student in virology or in virological diagnostic laboratories.
Syllabus
  • Cellular response to viral infection: characterization of changes in the infected cells, adsorption and penetration, replication of viral genome, metabolic changes in the infected cells, morphological changes in the infected cells (changes of the cytoplasm and nucleus, ultrastructure and chemical properties of viral inclusions, „viral factories“, formation of multinuclear cells, effect of viral infection on cell cycle and chromosomes). Transformation of cells by viral infection. Mechanisms of pathogenesis of viral infections at the organismal level: virus crossing the epithelial barrier, virus replication in ligament and crossing the vascular endothelium, virus spread in blood, lymph and via nerves, susceptibility of host tissues to viral infection. Viral determinants of virulence. Pathogenesis of viral infections of respiratory tract. Pathogenesis of viral hepatitis. Pathogenesis of neuroviral infections. Pathogenesis of viral hemorrhagic fevers. Pathogenesis of congenital viral infections. Chronic viral infections. Host defense mechanisms against viral infection.
Literature
    recommended literature
  • • SINGH, Sunit Kumar, Daniel RŮŽEK (Eds.) Neuroviral Infections: RNA Viruses and Retroviruses. 1st. ed., Boca Raton: CRC Press, 2013. 499 s. ISBN 1466567201
  • • RAJČÁNI, Július. Patogenéza vírusových nákaz. 1. vyd. Bratislava: VEDA, vydavateľstvo SAV, 1983. 326 s.
  • • SINGH, Sunit Kumar a Daniel RŮŽEK (Eds.) Neuroviral Infections: General Principles and DNA Viruses. 1st. ed., Boca Raton: CRC Press, 2013. 374 s. ISBN 9781466567191
  • • SINGH, Sunit Kuman a Daniel RŮŽEK (Eds.). Viral hemorrhagic fevers. 1st. ed. Boca Raton: CRC Press, 2013. 576 s. ISBN 9781439884294
  • FLINT, S. Jane. Principles of virology. 3rd ed. Washington, DC: ASM Press, 2009, xx, 419. ISBN 9781555814809. info
  • RAJČÁNI, Július and Fedor ČIAMPOR. Lekárska virológia. 1. vyd. Bratislava: VEDA vydavateľstvo Slovenskej akadémie vied, 2006, 574 s. ISBN 8022409111. info
Teaching methods
The lectures will be presented using presentations prepared in Microsoft Office Power Point. Moreover, educational schemes, illustrations, photographs and videos will be presented.
Assessment methods
Oral exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is taught: in blocks.
General note: Vyučovacím jazykem je pouze čeština.
The course is also listed under the following terms Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2023/Bi5051