C6930 Immunotoxicology

Faculty of Science
Spring 2001
Extent and Intensity
0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Luděk Bláha, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Luděk Bláha, Ph.D.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Immunotoxicology - research branch studying effects of stressors (mainly chemical compounds) on immune system and the importance of immune system changes for organism health.. Immune system - components, function, communication. Experimental design in immunotoxicology. Tiered approach. Laboratory methods in immunotoxicology. Factors affecting immune system. Special immunotoxicology - drugs, pollutants. Ecological immunotoxicology - invertebrates, fish, amphibians. Risk assessment in immunotoxicology.
Syllabus
  • 1. Immunotoxicology. Introduction, history, aims and scopes, human immunotoxicology, ecological immunotoxicology. 2. Immune system. Components of immune system, function, communication, immune system as a target of xenobiotics. Immune system as a part of an organism - interactions, controls, homeostasis, (xeno-)estrogens. 3. Experimental design in immunotoxicology. Exposure, response. "Tier I" and "Tier II" methods. Animal models in immunotoxicology, batteries of immunotoxicology tests. 4. Laboratory methods in immunotoxicology. Assays of immunocompetence, macrophage function assays, host resistance, antitumor immunity, hypersensitivity, autoimmunity. 5. Special immunotoxicology 1 - introduction. Factors affecting immune system (climate, geography, biorhythms, stress, social habits, chemicals, irradiation and other physico-chemical factors). 6. Special immunotoxicology 2 - immunotoxicology of drugs (antibiotics, important pharamceuticals, immunosuppressives a immunomodulators, antitumor therapy). 7. Special immunotoxicology 3 - immunotoxicology of pollutants (metals, pesticides, industrial chemicals - PCBs, PAHs, PCDD(F)s, other organic pollutants, azbestosis, silikosis). 8. Ecological immunotoxicology. Animal immune system and interactions with xenobiotics. Invertebrates, fish, amphibians, birds, mammals. Markers of immune system alterations, ecological consequences. Case studies. 9. Risk assessment. Immunotoxicology as a branch of general toxicology, hazard identification, uncertainities.
Literature
  • Immunotoxicology and immunopharmacology. Edited by Jack H. Dean. 2nd ed. New York: Raven Press, 1994, xxi, 761 s. ISBN 0-7817-0219-4. info
  • Wagner, V., Wagnerová, M. Ekoimunologie, Avicenum, 1988, Praha
  • Ferenčík, M. Immunochémia, Alfa, 1989, Bratislava
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Spring 2000, Autumn 2010 - only for the accreditation, Spring 2002, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Spring 2013, Autumn 2013, Spring 2014, Autumn 2014, Spring 2015, Autumn 2015, Spring 2016, Autumn 2016, Spring 2017, autumn 2017, spring 2018, Autumn 2018, Spring 2019, Autumn 2019, Spring 2020, Autumn 2020, autumn 2021.
  • Enrolment Statistics (Spring 2001, recent)
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