IC037 Bio-Organic Chemistry

Faculty of Science
Autumn 2011 - acreditation

The information about the term Autumn 2011 - acreditation is not made public

Extent and Intensity
1/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
Prof. Dr. Romano Orru (lecturer), prof. RNDr. Milan Potáček, CSc. (deputy)
Guaranteed by
prof. RNDr. Milan Potáček, CSc.
Department of Chemistry - Chemistry Section - Faculty of Science
Prerequisites
C3022 Organic Chemistry II
Basic knowledge of Organic Chemistry
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
After following the course, students should be able to: - Recognize and interconvert different forms of representation of natural products (e.g. carbohydrates); - Classify and analyze natural products according to their biosynthetic origin and describe the reactions involved in their biosynthesis; - Explain the most important mechanisms of major biosynthetic pathways; - Provide plausible mechanisms for conversions in natural product biosynthesis based on studied textbook examples;; - Explain what type of organism produces a specific compound based on the type of secondary metabolism involved in the biosynthesis; - Describe major cellular events and functions (and their place in the cell cycle) that can be perturbed by natural products; - Analyze structural modifications to biologically active natural products to give (semi)synthetic derivatives and explain how they may contribute to better pharmaceutical properties; - Understand the principles that determine the specificity and activity of enzymes and the mechanisms of some enzyme reactions on a molecular scale;
Syllabus
  • General The course Bio-Organic Chemistry consists The topic Natural Products, which gives a detailed overview of the fundamental classes of natural products. Not only the basic structural and physical properties, but also synthetic aspects and biosynthesis are a major part of this course. Furthermore, the role of natural products in biological studies and pharmaceutical development will be discussed.
Literature
  • Medicinal Natural Products – A Biosynthetic Approach”, 2nd edition, Paul M. Dewick, John Wiley & Sons, 2001, ISBN 13 978 0 471 49641 0
Teaching methods
Lectures with discussions
Language of instruction
English
Further comments (probably available only in Czech)
Course is no more offered.
The course is taught: in blocks.
Note related to how often the course is taught: 8.-10.12.2009.
The course is also listed under the following terms Autumn 2010 - only for the accreditation, Autumn 2009, Autumn 2010, Autumn 2011.